2006
DOI: 10.1016/j.ab.2006.07.033
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A biochemist’s guide to Caenorhabditis elegans

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Cited by 92 publications
(73 citation statements)
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References 85 publications
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“…To complete metamorphosis, insects experience different stages of ecdysis before becoming next stage larvae, pupae, and adults. Nematodes, including C. elegans, require four rounds of larval ecdysis to become adults (57). Therefore, this developmental difference may be due to different mechanisms that regulate ecdysis between Nematoda and insects.…”
Section: Discussionmentioning
confidence: 99%
“…To complete metamorphosis, insects experience different stages of ecdysis before becoming next stage larvae, pupae, and adults. Nematodes, including C. elegans, require four rounds of larval ecdysis to become adults (57). Therefore, this developmental difference may be due to different mechanisms that regulate ecdysis between Nematoda and insects.…”
Section: Discussionmentioning
confidence: 99%
“…The studies based on C. elegans have led to insights in neurobiology, ageing, development, genomics, and drug discovery. [1][2][3] Due to its simpler nervous system consisting of only 302 neurons, C. elegans is an ideal model system to understand neuronal signaling and function. One way to do this is through the analysis of movement based behavioral response to an external stimulus.…”
Section: Introductionmentioning
confidence: 99%
“…4,5) In this study, we used Caenorhabditis elegans as a live model to detect the biological activities of isoquinoline alkaloids, since this worm offers several distinct advantages in preliminary screening, in terms of cost, time, and ease of manipulation, as well as effectiveness in gene-to-drug screening. 6,7) Furthermore, an intact animal offers advantages over in vitro or cell-based assays for subsequent application to the whole animal. 8) In addition, C. elegans largely shares the core mechanisms of the regulatory pathways of mammalian energy homeostasis.…”
mentioning
confidence: 99%