A biocompatible implant electrode capable of operating in body fluids for energy storage devices

Chae, Ji Su; Heo, Nam Su; Kwak, Cheol Hwan; Cho, Wan Seob; Seol, Geun Hee; Yoon, Won‐Sub; Kim, Hyun Kyung; Fray, D. J.; Vilian, A.T. Ezhil; Han, Yong; Huh, Yun Suk; Roh, Kwang Chul

doi:10.1016/j.nanoen.2017.02.018

Cited by 56 publications

(33 citation statements)

References 24 publications

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“…Different from the abovementioned energy strategies, harvesting energy locally may serve a more compatible and sustainable way for powering WIEs. Among a few accessible energy sources, [ 41,42 ] biomechanical energy is an abundant and primary source that exists widely in human bodies. NG, an emerging technology based on nanoscale electromechanical coupling, is effective and versatile for directly converting available biomechanical energy in human body into useful electricity.…”

Section: Power Supply and Ngsmentioning

confidence: 99%

Wearable and Implantable Electroceuticals for Therapeutic Electrostimulations

Long

Yang

et al. 2021

Advanced Science

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Wearable and implantable electroceuticals (WIEs) for therapeutic electrostimulation (ES) have become indispensable medical devices in modern healthcare. In addition to functionality, device miniaturization, conformability, biocompatibility, and/or biodegradability are the main engineering targets for the development and clinical translation of WIEs. Recent innovations are mainly focused on wearable/implantable power sources, advanced conformable electrodes, and efficient ES on targeted organs and tissues. Herein, nanogenerators as a hotspot wearable/implantable energy-harvesting technique suitable for powering WIEs are reviewed. Then, electrodes for comfortable attachment and efficient delivery of electrical signals to targeted tissue/organ are introduced and compared. A few promising application directions of ES are discussed, including heart stimulation, nerve modulation, skin regeneration, muscle activation, and assistance to other therapeutic modalities.

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Section: Power Supply and Ngsmentioning

confidence: 99%

Wearable and Implantable Electroceuticals for Therapeutic Electrostimulations

Long

Yang

et al. 2021

Advanced Science

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“…By incorporating various materials in the thin film formats, including metals, oxides, silicon, carbon materials, and organic polymers, supercapacitors can be reformulated into novel, flexible, stretchable, and biodegradable (or edible) systems that can better adapt to the human body . Chae et al implanted two biocompatible hybrid electrodes fabricated by MnO 2 and carbon into the subcutaneous layer of rat's skin as shown in Figure a, demonstrating a stable supercapacitor performance (0.2–1 V at 2 mA) for 5000 cycles …”

Section: Energy Storage Systemsmentioning

confidence: 99%

“…Implantable supercapacitors: a) A supercapacitor consisting of MnO 2 and carbon materials implanted into the subcutaneous layer of the rat's skin. Reproduced with permission . Copyright 2017, Elsevier.…”

Section: Energy Storage Systemsmentioning

confidence: 99%

Materials Strategies and Device Architectures of Emerging Power Supply Devices for Implantable Bioelectronics

Huang

Wang

et al. 2019

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107

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Implantable bioelectronics represent an emerging technology that can be integrated into the human body for diagnostic and therapeutic functions. Power supply devices are an essential component of bioelectronics to ensure their robust performance. However, conventional power sources are usually bulky, rigid, and potentially contain hazardous constituent materials. The fact that biological organisms are soft, curvilinear, and have limited accommodation space poses new challenges for power supply systems to minimize the interface mismatch and still offer sufficient power to meet clinical‐grade applications. Here, recent advances in state‐of‐the‐art nonconventional power options for implantable electronics, specifically, miniaturized, flexible, or biodegradable power systems are reviewed. Material strategies and architectural design of a broad array of power devices are discussed, including energy storage systems (batteries and supercapacitors), power devices which harvest sources from the human body (biofuel cells, devices utilizing biopotentials, piezoelectric harvesters, triboelectric devices, and thermoelectric devices), and energy transfer devices which utilize sources in the surrounding environment (ultrasonic energy harvesters, inductive coupling/radiofrequency energy harvesters, and photovoltaic devices). Finally, future challenges and perspectives are given.

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“…To develop soft IE applications, conductive hydrogels have attracted attention as a candidate substrate for IEs because hydrogels can retain abundant water molecules similar to tissues, and the moist environment can offer a consecutive ionic conductivity [ 7 ]. Nevertheless, there are many other requirements for a proper conductive hydrogel, including biocompatibility [ 8 , 9 , 10 ], stretchability [ 11 ], self-healing [ 12 ], and conductivity [ 13 ]. It is difficult to find an appropriate material with balanced electronic and mechanical properties.…”

Section: Introductionmentioning

confidence: 99%

Self-Healing, Stretchable, Biocompatible, and Conductive Alginate Hydrogels through Dynamic Covalent Bonds for Implantable Electronics

et al. 2021

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Implantable electronics have recently been attracting attention because of the promising advances in personalized healthcare. They can be used to diagnose and treat chronic diseases by monitoring and applying bioelectrical signals to various organs. However, there are challenges regarding the rigidity and hardness of typical electronic devices that can trigger inflammatory reactions in tissues. In an effort to improve the physicochemical properties of conventional implantable electronics, soft hydrogel-based platforms have emerged as components of implantable electronics. It is important that they meet functional criteria, such as stretchability, biocompatibility, and self-healing. Herein, plant-inspired conductive alginate hydrogels composed of “boronic acid modified alginate” and “oligomerized epigallocatechin gallate,” which are extracted from plant compounds, are proposed. The conductive hydrogels show great stretchability up to 500% and self-healing properties because of the boronic acid-cis-diol dynamic covalent bonds. In addition, as a simple strategy to increase the electrical conductivity of the hydrogels, ionically crosslinked shells with cations (e.g., sodium) were generated on the hydrogel under physiological salt conditions. This decreased the resistance of the conductive hydrogel down to 900 ohm without trading off the original properties of stretchability and self-healing. The hydrogels were used for “electrophysiological bridging” to transfer electromyographic signals in an ex vivo muscle defect model, showing a great bridging effect comparable to that of a muscle-to-muscle contact model. The use of plant-inspired ionically conductive hydrogels is a promising strategy for designing implantable and self-healable bioelectronics.

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A biocompatible implant electrode capable of operating in body fluids for energy storage devices

Cited by 56 publications

References 24 publications

Wearable and Implantable Electroceuticals for Therapeutic Electrostimulations

Wearable and Implantable Electroceuticals for Therapeutic Electrostimulations

Materials Strategies and Device Architectures of Emerging Power Supply Devices for Implantable Bioelectronics

Self-Healing, Stretchable, Biocompatible, and Conductive Alginate Hydrogels through Dynamic Covalent Bonds for Implantable Electronics

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