A biodegradable injectable fluorescent polyurethane-oxidized dextran hydrogel for non-invasive monitoring

Wang, Xiao; Ou, Yangcen; Wang, Xiaofei; Yuan, Lei; He, Nan; Li, Zhen; Luo, Feng; Li, Jiehua; Tan, Hong

doi:10.1039/d3tb01488f

Cited by 7 publications

(3 citation statements)

References 52 publications

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“…Wang and coworkers mixed a fluorescent polyurethane emulsion containing tetraphenyl ethylene with oxidized dextran to form a polyurethane-based hydrogel by a dynamic acylhydrazone bond. They showed that the remaining weight of the hydrogel was only about 20% of the initial weight after 96 h of subcutaneous implantation [197]. Similar to other biodegradable polymers, PUbased adhesives are mainly applied in hemostasis [198], wound healing [199], cell and drug delivery [200][201][202], and tissue regeneration [203].…”

Section: Polyurethanesmentioning

confidence: 99%

Recent Advances in the Degradability and Applications of Tissue Adhesives Based on Biodegradable Polymers

Zhu,

Dou,

Zeng

et al. 2024

IJMS

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In clinical practice, tissue adhesives have emerged as an alternative tool for wound treatments due to their advantages in ease of use, rapid application, less pain, and minimal tissue damage. Since most tissue adhesives are designed for internal use or wound treatments, the biodegradation of adhesives is important. To endow tissue adhesives with biodegradability, in the past few decades, various biodegradable polymers, either natural polymers (such as chitosan, hyaluronic acid, gelatin, chondroitin sulfate, starch, sodium alginate, glucans, pectin, functional proteins, and peptides) or synthetic polymers (such as poly(lactic acid), polyurethanes, polycaprolactone, and poly(lactic-co-glycolic acid)), have been utilized to develop novel biodegradable tissue adhesives. Incorporated biodegradable polymers are degraded in vivo with time under specific conditions, leading to the destruction of the structure and the further degradation of tissue adhesives. In this review, we first summarize the strategies of utilizing biodegradable polymers to develop tissue adhesives. Furthermore, we provide a symmetric overview of the biodegradable polymers used for tissue adhesives, with a specific focus on the degradability and applications of these tissue adhesives. Additionally, the challenges and perspectives of biodegradable polymer-based tissue adhesives are discussed. We expect that this review can provide new inspirations for the design of novel biodegradable tissue adhesives for biomedical applications.

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Section: Polyurethanesmentioning

confidence: 99%

Recent Advances in the Degradability and Applications of Tissue Adhesives Based on Biodegradable Polymers

Zhu,

Dou,

Zeng

et al. 2024

IJMS

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“…Waterborne polyurethane is a multiblock polymer that has been used in biomedical fields due to its good biocompatibility and flexible structural design. , Here, a new class of Janus adhesive patches was prepared by controlling the distribution of functional groups (such as cations, –NH–, CO, etc.) on each side of the waterborne polyurethane after spontaneous segment separation and migration.…”

Section: Introductionmentioning

confidence: 99%

Janus Polyurethane Adhesive Patch with Antibacterial Properties for Wound Healing

Guo,

Wang,

Sheng

et al. 2024

ACS Appl. Mater. Interfaces

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Despite the rapid development of tissue adhesives, flaws including allergies, poor stability, and indiscriminate doublesided adhesive properties limit their application in the medical field. In this work, Janus polyurethane patches were spontaneously prepared by adjusting the difference in the functional group distribution between the top and bottom sides of the patch during emulsion drying. Consequently, poor adhesion was exhibited on the bottom surface, while the top surface can easily adhere to metals, polymers, glasses, and tissues. The difference in adhesive strength to pork skin between the two surfaces is more than 5 times. The quaternary ammonium salt and hydrophilic components on the surface of the polyurethane patch enable the rapid removal and absorption of water from the tissue surface to achieve wet adhesion. Animal experiments have demonstrated that this multifunctional Janus polyurethane patch can promote skin wound closure and healing of infected wounds. This facile and effective strategy to construct Janus polyurethane patch provides a promising method for the development of functional tissue-adhesives.

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“…[ 29 ] Due to its exceptional biocompatibility, polyurethane has found extensive applications in the biomedical field. [ 30 , 31 , 32 ] The polyurethane medical adhesive exhibits excellent properties such as high reactivity and room temperature curing. [ 33 , 34 ] Ideal tissue adhesives require rapid curing, whereas polyurethane prepolymers typically necessitate longer curing times, thereby limiting their use in tissue bonding.…”

Section: Introductionmentioning

confidence: 99%

Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties

Guo,

Zhao,

Yuan

et al. 2024

Advanced Science

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Underwater adhesives with injectable, organic solvent‐free, strong, fast adhesion, and hemostatic properties have become an urgent need in biomedical field. Herein, a novel polyurethane underwater adhesive (PUWA) inspired by mussels is developed utilizing the rapid post‐cure reaction of isocyanate esterification without organic solvents. The PUWA is created through the injectable two component curing process of component A (biocompatible polyurethane prepolymer) and component B (dopamine modified lysine derivatives: chain extender‐LDA and crosslinker‐L3DA). The two‐component adhesive cures quickly and firmly underwater, with an impressive bonding strength of 40 kPa on pork skin and excellent burst pressure of 394 mmHg. Moreover, the PUWA exhibits robust adhesion strength in hostile environments with acid, alkali and saline solutions. Combined with excellent biocompatibility and hemostatic performance, the PUWA demonstrates effectively sealing wounds and promoting healing. With the ability to bond diverse substrates rapidly and strongly, the PUWA holds significant potential for application in both biomedical and industrial fields.

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A biodegradable injectable fluorescent polyurethane-oxidized dextran hydrogel for non-invasive monitoring

Abstract: Hydrogels have been extensively used in the field of biomedical engineering. In order to achieve non-invasive and real-time visualization of the in vivo status of hydrogels, we designed a fluorescent...

Cited by 7 publications

References 52 publications

Recent Advances in the Degradability and Applications of Tissue Adhesives Based on Biodegradable Polymers

Recent Advances in the Degradability and Applications of Tissue Adhesives Based on Biodegradable Polymers

Janus Polyurethane Adhesive Patch with Antibacterial Properties for Wound Healing

Bioinspired Injectable Polyurethane Underwater Adhesive with Fast Bonding and Hemostatic Properties

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