A Bioinspired Gelatin–Amorphous Calcium Phosphate Coating on Titanium Implant for Bone Regeneration

Abstract

Biocompatible and bio‐active coatings can enhance and accelerate osseointegration via chemical binding onto substrates. Amorphous calcium phosphate (ACP) has been shown as a precursor to achieve mineralization in vertebrates and invertebrates under the control of biological macromolecules. This work presents a simple bioinspired Gelatin‐CaPO4 (Gel‐CaP) composite coating on titanium surfaces to improve osseointegration. The covalently bound Gel‐CaP composite is characterized as an ACP‐Gel compound via SEM, FT‐IR, XRD, and HR‐TEM. The amorphous compound coating exhibits a nanometer range thickness and improved elastic modulus, good wettability, and nanometric roughness. The amount of grafted carboxyl groups and theoretical thickness of the coatings are also investigated. More importantly, MC3T3 cells, an osteoblast cell line, show excellent cell proliferation and adhesion on the Gel‐CaP coating. The level of osteogenic genes is considerably upregulated on Ti with Gel‐CaP coatings compared to uncoated Ti, demonstrating that Gel‐CaP coatings possess a unique osteogenic ability. To conclude, this work offers a new perspective on functional, bioactive titanium coatings, and Gel‐CaP composites can be a low‐cost and promising candidate in bone regeneration.

Fabricating a PDA-NOate@CuS coated NIR-activatable titanium implant to realize simultaneous antiinfection and osseointegration

“…47 In addition, the ratio of nanohardness ( H ) to Young's modulus (elastic modulus, E ) was calculated to evaluate the elastic strain of coating failure. 48 The H / E values of Ti@PDA-NOate/CuS were higher than Ti (0.016 compared to 0.013, respectively), indicating that Ti@PDA-NOate/CuS may have better wear resistance.…”

A multifunctional ionic liquid coating on 3D-Printed prostheses: Combating infection, promoting osseointegration

“…1 a) demonstrated the homogeneous and porous network microstructure of the obtained pTi prosthesis. The interconnected microstructure would benefit cell penetration and nutrient transport, promoting angiogenesis and induce bone ingrowth [ 33 , 34 ]. Besides, the microstructure increased the surface roughness and specific surface area to enhance the prosthesis–bone interaction and initial stability, so that the micro-movements at the interface could be minimized.…”

Advances in reparative materials for infectious bone defects and their applications in maxillofacial regions

“…137 Experiments utilizing various types of cells including human mesenchymal stem cells and osteoblast-like cells have demonstrated that CaP coatings promote cellular attachment, growth, and specialization, thereby promoting bone regeneration. 138,139 Building upon this foundation, the field of research now focuses on biofunctional hybrid composite CaP coatings containing both inorganic CaP coating and organic elements designed to stimulate tissue growth and promote the formation of blood vessels. To further explore the therapeutic outcomes of hybrid calcium phosphate coatings, various studies have investigated the impacts of implanted material design, surgical procedure, and coating characteristics ( e.g.…”