A biological characteristic extrapolation of compound toxicity for different developmental stage species with toxicokinetic-toxicodynamic model

Gao, Yongfei; Xie, Zhicheng; Feng, Mingfeng; Feng, Jianfeng; Zhu, Lin

doi:10.1016/j.ecoenv.2020.111043

Cited by 3 publications

(1 citation statement)

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“…The parameter C IT reflects the toxicity of bioavailable metal: higher C IT values indicate a higher toxicity threshold concentration . Aquatic species with smaller body sizes are always associated with a lower C IT and are more sensitive to toxicants, , which further indicates the relationship between C IT and metal toxicity. However, the parameter C IT can explain well the toxicity of Cd, Pb, and Zn, but it cannot explain why the toxicity of Cu is higher than those of Cd and Pd (Figure A).…”

Section: Resultsmentioning

confidence: 99%

Role of Toxicokinetic and Toxicodynamic Parameters in Explaining the Sensitivity of Zebrafish Larvae to Four Metals

Yang

Feng

Gao

et al. 2021

Environ. Sci. Technol.

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Given the persistence and toxic potencies of metal contaminants in ecosystems, animals, and human beings, they are considered to be hazardous global pollutants. While the lethality of metal toxicities (e.g., LC50) can significantly vary, even within the same species, the underlying mechanisms are less well-understood. In this study, we developed a subcellular two-compartment toxicokinetic-toxicodynamic (TK-TD) model for zebrafish larvae when exposed to four metals (cadmium, lead, copper, and zinc) to reveal whether differences in metal toxicity (LC50 values) were dominated by the TK or TD processes. Results showed that the subcellular TK and TD parameters of the four metals were significantly different, and the bioconcentration factor (BCF) value of copper was higher than those of the other metals. We also found that the TD parameter internal threshold concentration (C IT) was significantly positively correlated to the LC50 values (R 2 = 0.7), suggesting a dominant role of TD processes in metal toxicity. Furthermore, the combined parameter C IT /BCF for a metal-sensitive fraction (BCFMSF), which linked exposure to effects through the TK-TD approach, explained up to 89% of the variation in toxicity to the four metals. The present study suggests that the observed variation in toxicity of these four metals was mainly determined by TD processes but that TK processes should not be ignored, especially for copper.

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Section: Resultsmentioning

confidence: 99%