A Biomimetic Silk Fibroin/Sodium Alginate Composite Scaffold for Soft Tissue Engineering

Wang, Yiyu; Wang, Xinyu; Shi, Jian; Zhu, Rong; Zhang, Junhua; Zhang, Zongrui; Ma, Daiwei; Hou, Yuanjing; Lin, Fei; Yang, Jing; Mizuno, Mamoru

doi:10.1038/srep39477

Cited by 156 publications

(114 citation statements)

References 46 publications

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“…Fig. This result is comparable with the studies reported by Wang et al [29] and Boateng and Areago [30]. There are different phases between scaffolds with and without the cockle shell powder.…”

Section: Characterization Of Bone Scaffoldssupporting

confidence: 91%

Fabrication of Bone Scaffolds from Cockle Shell Waste

2019

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Bone scaffold is a three-dimensional structure composed of materials that could enhance bone regeneration. Bone scaffolds were prepared using freeze-drying by varying the cockle shell powder concentration where sodium alginate acted as matrix. The scaffolds were then characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, texture analyzer, and liquid displacement method. The bioactivity of the scaffolds was evaluated by immersion into a simulated body fluid solution. Cockle shell powder concentrations affected the bone scaffold characteristics. The increment of the powder concentrations improved the physicochemical properties and bioactivity of the scaffolds.

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Section: Characterization Of Bone Scaffoldssupporting

confidence: 91%

Fabrication of Bone Scaffolds from Cockle Shell Waste

2019

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“…The water stability of the scaffolds under different conditions was studied to confirm the crosslinking reaction between SF and CS. 58–60 The untreated scaffolds easily dissolved in water at 37 °C, because CS and SF with a low beta sheet content are water soluble (Figure 1C). When the scaffolds were immersed in methanol without EDC for 3 h, pure CS scaffolds remained soluble in water, while the weight loss was 19%, 15%, 12%, 8% and 4% for S2-C, S4-C, S6-C, S8-C, and pure SF, respectively, because the CS was soluble after methanol treatment.…”

Section: Resultsmentioning

confidence: 99%

Simulation of ECM with silk and chitosan nanocomposite materials

Ding

et al. 2017

J. Mater. Chem. B

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Extracellular matrix (ECM) is a system used to model the design of biomaterial matrices for tissue regeneration. Various biomaterial systems have been developed to mimic the composition or microstructure of the ECM. However, emulating multiple facets of the ECM in these systems remains a challenge. Here, a new strategy is reported which addresses this need by using silk fibroin and chitosan (CS) nanocomposite materials. Silk fibroin was first assembled into ECM-mimetic nanofibers in water and then blended with CS to introduce the nanostructural cues. Then the ratios of silk fibroin and CS were optimized to imitate the protein and glycosaminoglycan compositions. These biomaterial scaffolds had suitable compositions, hierarchical nano-to-micro structures, and appropriate mechanical properties to promote cell proliferation in vitro, and vascularization and tissue regeneration in vivo. Compared to previous silk-based scaffolds, these scaffolds achieved improvements in biocompatibility, suggesting promising applications in the future in tissue regeneration.

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“…Alginate is highly hydrophilic, biocompatible, relatively economical and biodegradable under normal physiological conditions [46]. Owing to its unique physiological properties, composite scaffolds have been found successful with alginate combined with different other biomaterials like HAp [47], chitosan [48], collagen [49] and silk fibroin [50] for bone regeneration.…”

Section: Alginatementioning

confidence: 99%

Naturally derived biomaterials for development of composite bone scaffold: A review

Barua

Deoghare

Deb

et al. 2018

IOP Conf. Ser.: Mater. Sci. Eng.

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E-mail: imon18enator@gmail.comAbstract. Over the last few decades, there has been an increasing demand of tissue engineered bone scaffolds as a substitute material for diseased or damaged bone segments. A variety of synthetic and natural biomaterials have been explored by researchers for development of composite scaffold. Naturally derived biomaterials have the advantages of immunomodulating, anti-toxic and biomimetic properties with the cellular environment in vivo, when compared to synthetic biomaterials. In this paper, different protein and polysaccharide based biomaterials used for developing composite bone scaffolds are reviewed. The properties of composite scaffolds developed from these biomaterials are highlighted. The study also includes different natural materials and biowastes which are used for deriving bioceramics for producing composite bone scaffolds. The overall study gives a brief idea on the importance of protein and polysaccharide based biomaterials and bioceramics for composite bone scaffold development and scope for future work in the field of naturally derived biomaterials.

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A Biomimetic Silk Fibroin/Sodium Alginate Composite Scaffold for Soft Tissue Engineering

Cited by 156 publications

References 46 publications

Fabrication of Bone Scaffolds from Cockle Shell Waste

Fabrication of Bone Scaffolds from Cockle Shell Waste

Simulation of ECM with silk and chitosan nanocomposite materials

Naturally derived biomaterials for development of composite bone scaffold: A review

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