A bioorthogonal assembly based on metallophilic interactions for selective imaging and PDT treatment of cancer cells

Abstract

Precise control of the luminescence and singlet oxygen generation is important for selective photo-theranostics applications. In this work, bioorthogonal assembly based on d10···d10 metallophilic interactions was first proposed for selective...

Metallophilic Interactions Drive Supramolecular Chirality Evolution and Amplify Circularly Polarized Luminescence

“…reported a series of NHC–gold (I) complex salts [Au­(NHC) 2 ]­[MX 2 ] (M = Au or Cu; X = halide, cyanide, or arylacetylide) consisting of alternating cations and anions arranged into one-dimensional (1D) chains. These further generated supramolecular polymers with tunable luminescence properties, in which the synergetic Au···M interactions and Coulombic attraction directed the co-assembly. ,− Among these complex salts, a pair of chiral [Au­(NHC) 2 ]­[Au­(CN) 2 ] complex double salts displayed excitation-wavelength-dependent circularly polarized luminescence (CPL) . The tunable Au···Au distances were proven to be responsible for the tunable photoluminescence (PL).…”

Modulating the Chemical Reactivity of Gold Complexes in Living Systems: From Concept to Biomedical Applications

“…55 Last but not least, both gold(I) and gold(III) complexes have the tendency to form supramolecular polymers due to either aurophilicity or π stacking interactions, which has been demonstrated to be useful for bioorthogonal photodynamic therapy and for drug delivery to minimize side effects. 45,53,59…”

“…Particularly, gold­(III) meso-tetraphenylporphyrin, named gold- 1a ( 29 , Figure ) shows very promising antitumor activities in a series of tumor models, and it is being tested at various stages of preclinical trials . Last but not least, both gold­(I) and gold­(III) complexes have the tendency to form supramolecular polymers due to either aurophilicity or π stacking interactions, which has been demonstrated to be useful for bioorthogonal photodynamic therapy and for drug delivery to minimize side effects. ,, …”

Unusually short unsupported Au(iii)⋯Au(iii) aurophilic contacts in emissive lanthanide tetracyanoaurate(iii) complexes

“…Metallophilic interactions between d 8 or d 10 metal centres, particularly with Pt(II) or Au(I), can greatly influence the structures of supramolecular assemblies; harnessing these interactions as crystal engineering tools has allowed many functional materials to be designed. [1][2][3][4] Further, metallophilic interactions have become relevant to diverse areas of research, including the design of pharmaceuticals, [5][6][7] catalysts, 8-10 metallogels, 11 molecular nanowires, 12,13 stimuli-responsive materials, [14][15][16][17][18] and organic light-emitting diodes (OLEDs). [19][20][21] In contrast, aurophilic interactions between d 8 Au(III) centres are extremely rare, with only eleven compounds exhibiting unsupported Au(III)Á Á ÁAu(III) interactions having been reported (Table S1, ESI †).…”