This paper presents an approach for solving a new real problem in Cutting and Packing. At its core is an innovative mixed integer programme model that places irregular pieces and defines guillotine cuts. The two-dimensional irregular shape bin packing problem with guillotine constraints arises in the glass cutting industry, for example, the cutting of glass for conservatories. Almost all cutting and packing problems that include guillotine cuts deal with rectangles only, where all cuts are orthogonal to the edges of the stock sheet and a maximum of two angles of rotation are permitted. The literature tackling packing problems with irregular shapes largely focused on strip packing i.e. minimizing the length of a single fixed width stock sheet, and does not consider guillotine cuts. Hence, this problem combines the challenges of tackling the complexity of packing irregular pieces with free rotation, guaranteeing guillotine cuts that are not always orthogonal to the edges of the stock sheet, and allocating pieces to bins. To our knowledge only one other recent paper tackles this problem. We present a hybrid algorithm that is a constructive heuristic that determines the relative position of pieces in the bin and guillotine constraints via a mixed integer programme model. We investigate two approaches for allocating guillotine cuts at the same time as determining the placement of the piece, and a two phase approach that delays the allocation of cuts to provide flexibility in space usage. Finally we describe an improvement procedure that is applied to each bin before it is closed. This approach improves on the results of the only other publication on this problem, and gives competitive results for the classic rectangle bin packing problem with guillotine constraints.