A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery

Panja, Subhash Chandra; Maji, Somnath; Maiti, Tapas K.; Chattopadhyay, Santanu

doi:10.1016/j.polymer.2015.01.075

Cited by 20 publications

(12 citation statements)

References 56 publications

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“…The release curves of the PCL- b -PMPC/DOX and PCL- b -PMPC-FA/DOX micelles (Figure ) were similar in 48 h, showing a relatively rapid release in the first 10 h and a sustained release for the next 38 h. In addition, both micelles showed faster DOX release at pH 5.0, which was attributed to the increased solubility of DOX due to the protonation of DOX’s amino group at pH 5.0. The phenomenon that the micelles have faster DOX release in the acidic medium than under physiological conditions has been found in other kinds of polymeric micelles, which might improve intracellular drug release after their entry into the tumor cells or endosomes/lysosomes. ,,− Moreover, the PCL- b -PMPC-FA/DOX micelles showed a faster release irrespective of the pH, maybe due to the interaction of FA with DOX. A similar result was reported in the literature …”

Section: Resultsmentioning

confidence: 80%

“…Azide and click reactions were carried out to synthesize the copolymer PCL- b -PMPC-FA (Scheme ). First, azide-terminated PCL- b -PMPC copolymer, PCL- b -PMPC-N 3 , was synthesized by the reaction of PCL- b -PMPC and NaN 3 (sodium azide) in a THF/CH 3 OH mixed solvent at 70 °C in the dark for 24 h. Then PCL- b -PMPC-N 3 and excess alkynyl folic acid were used to synthesize the copolymer PCL- b -PMPC-FA through typical ATRP. The detailed synthesis procedures are presented in Supporting Information.…”

Section: Methodsmentioning

confidence: 99%

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Synthesis and Characterization of Folate-Modified Cell Membrane Mimetic Copolymer Micelles for Effective Tumor Cell Internalization

Zhang

et al. 2021

ACS Appl. Bio Mater.

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The inefficient targeting and phagocytic clearance of nanodrug delivery systems are two major obstacles in cancer therapy. Here, inspired by the special properties of zwitterionic polymers and folic acid (FA), a partly biodegradable copolymer of FA-modified poly(ε-caprolactone) block poly(2-methacryloxoethyl phosphorylcholine), PCL-b-PMPC-FA, was synthesized via atom transfer radical polymerization (ATRP) and click reaction. Non-FA-modified copolymer PCL-b-PMPC was also synthesized as a control. The hydrodynamic diameter of the PCL-b-PMPC-FA micelles is 158 nm (PDI 0.261), slightly larger than that of the PCL-b-PMPC micelles (139 nm, PDI 0.242). The drug doxorubicin (DOX) could be entrapped in the micelles, and as the pH decreased from 7.4 to 5.0, DOX release (in vitro) was accelerated. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay indicated that both the PCL-b-PMPC and the PCL-b-PMPC-FA micelles showed low toxicity to L929, HeLa, and MCF-7 cells. In addition, the DOX-loaded micelles, PCL-b-PMPC/DOX and PCL-b-PMPC-FA/DOX micelles, exhibited low toxicity to L929 cells but high toxicity to HeLa and MCF-7 cells, especially the PCL-b-PMPC-FA/DOX micelles. HeLa and MCF-7 cell uptakes of the PCL-b-PMPC-FA/DOX micelles were 4.8 and 4.5 times higher than that of the PCL-b-PMPC/DOX micelles, respectively. Therefore, PCL-b-PMPC-FA micelles have great potential for developing drug delivery systems with extended circulation times and tumor-targeting properties.

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Section: Resultsmentioning

confidence: 80%

Section: Methodsmentioning

confidence: 99%

Synthesis and Characterization of Folate-Modified Cell Membrane Mimetic Copolymer Micelles for Effective Tumor Cell Internalization

Zhang

et al. 2021

ACS Appl. Bio Mater.

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“…The viability (in percentage) of MG63 cells with CD and polymeric systems was investigated by MTT assay . A count of 1 × 10 4 cells was seeded on a 96 well plates, which were already coated with the tested polymers viz.…”

Section: Methodsmentioning

confidence: 99%

Nano‐Bio Engineered Carbon Dot‐Peptide Functionalized Water Dispersible Hyperbranched Polyurethane for Bone Tissue Regeneration

Gogoi

Maji

Mishra

et al. 2016

Macromolecular Bioscience

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The present study delves into a combined bio-nano-macromolecular approach for bone tissue engineering. This approach relies on the properties of an ideal scaffold material imbued with all the chemical premises required for fostering cellular growth and differentiation. A tannic acid based water dispersible hyperbranched polyurethane is fabricated with bio-nanohybrids of carbon dot and four different peptides (viz. SVVYGLR, PRGDSGYRGDS, IPP, and CGGKVGKACCVPTKLSPISVLYK) to impart target specific in vivo bone healing ability. This polymeric bio-nanocomposite is blended with 10 wt% of gelatin and examined as a non-invasive delivery vehicle. In vitro assessment of the developed polymeric system reveals good osteoblast adhesion, proliferation, and differentiation. Aided by this panel of peptides, the polymeric bio-nanocomposite exhibits in vivo ectopic bone formation ability. The study on in vivo mineralization and vascularization reveals the occurrence of calcification and blood vessel formation. Thus, the study demonstrates carbon dot/peptide functionalized hyperbranched polyurethane gel for bone tissue engineering application.

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“…Majority of them utilizes temperature, pH, light, reduction, and ionic strength as the stimuli. Some recent studies related to single‐stimuli responsiveness include thermo‐responsive nanoswitch for in vivo sensing applications,13 pH‐responsive nanocarriers,14 redox‐responsive polymer‐drug conjugates for cancer therapy,15 photo‐responsive self‐assembly and therapeutic release of anticancer drugs,16 glucose‐responsive polymer‐vesicles,17 and thermo‐responsive “on demand” enzymatic activity of hydrogels prepared by polymerizing poly(ethylene glycol) dimethacrylate 750, poly( N ‐isopropylacrylamide) (PNIPAM) and Pepsin 18. The hydrogel acted as most effective catalyst at 25 °C.…”

Section: Single‐stimuli Responsivenessmentioning

confidence: 99%

Multi‐Stimuli‐Responsive Polymeric Materials

Guragain

Bastakoti

Malgras

et al. 2015

Chemistry A European J

201

114

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Stimuli-responsive materials are of immense importance because of their ability to undergo alteration of their properties in response to their environment. The properties of such materials can be tuned by subtle adjustments in temperature, pH, light, and so forth. Among such smart materials, multi-stimuli-responsive polymeric materials are of pronounced significance as they offer a wide range of applications and their properties can be tuned through several mechanisms. Here, we aim to highlight some recent studies showcasing the multi-stimuli-responsive character of these polymers, which are still relatively little known compared to their single-stimuli-responsive counterpart.

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A branched polymer as a pH responsive nanocarrier: Synthesis, characterization and targeted delivery

Cited by 20 publications

References 56 publications

Synthesis and Characterization of Folate-Modified Cell Membrane Mimetic Copolymer Micelles for Effective Tumor Cell Internalization

Synthesis and Characterization of Folate-Modified Cell Membrane Mimetic Copolymer Micelles for Effective Tumor Cell Internalization

Nano‐Bio Engineered Carbon Dot‐Peptide Functionalized Water Dispersible Hyperbranched Polyurethane for Bone Tissue Regeneration

Multi‐Stimuli‐Responsive Polymeric Materials

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