A brief review concerning the latest advances in the influence of nanoparticle reinforcement into polymeric-matrix biomaterials

Montanheiro, Thaís Larissa do Amaral; Ribas, Renata Guimarães; Montagna, Larissa Stieven; Menezes, Beatriz Rossi Canuto de; Schatkoski, Vanessa Modelski; Rodrigues, Karla Faquine; Thim, Gilmar Patrocínio

doi:10.1080/09205063.2020.1781527

Cited by 19 publications

(7 citation statements)

References 105 publications

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“…PCL was selected as the major component of scaffolds because it is easy to process by 3D printing, is biodegradable and biocompatible, and possesses adequate mechanical strength. However, the hydrophobic surface and lack of osteoconductivity of the PCL matrix represents some disadvantages, which can impair cells adhesion and proliferation [42,43]. Therefore, HA incorporation was considered to enhance scaffolds' performance, providing more strength and improving cellular activities, including cell attachment, proliferation, and differentiation [17,44].…”

Section: Discussionmentioning

confidence: 99%

3D Printed Poly(𝜀-caprolactone)/Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties

Biscaia

Branquinho

Alvites

et al. 2022

IJMS

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Bone tissue engineering has been developed in the past decades, with the engineering of bone substitutes on the vanguard of this regenerative approach. Polycaprolactone-based scaffolds are fairly applied for bone regeneration, and several composites have been incorporated so as to improve the scaffolds’ mechanical properties and tissue in-growth. In this study, hydroxyapatite is incorporated on polycaprolactone-based scaffolds at two different proportions, 80:20 and 60:40. Scaffolds are produced with two different blending methods, solvent casting and melt blending. The prepared composites are 3D printed through an extrusion-based technique and further investigated with regard to their chemical, thermal, morphological, and mechanical characteristics. In vitro cytocompatibility and osteogenic differentiation was also assessed with human dental pulp stem/stromal cells. The results show the melt-blending-derived scaffolds to present more promising mechanical properties, along with the incorporation of hydroxyapatite. The latter is also related to an increase in osteogenic activity and promotion. Overall, this study suggests polycaprolactone/hydroxyapatite scaffolds to be promising candidates for bone tissue engineering, particularly when produced by the MB method.

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Section: Discussionmentioning

confidence: 99%

3D Printed Poly(𝜀-caprolactone)/Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties

Biscaia

Branquinho

Alvites

et al. 2022

IJMS

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“…Nanoparticles have been utilized in orthodontics, prosthodontics, and restorative dentistry with the objective to improve materials’ mechanical properties and reduce the microbial load adjacent or attached to different types of restorations [ 53 ]. Previous studies confirmed that the incorporation of metaloxide nanoparticles into dental polymers resulted in experimental materials with improved physical, mechanical, biological, and biocompatibility properties, thereby supporting the continued development and characterization of nanofilled materials [ 29 , 54 , 55 ]. However, despite these encouraging findings, recent reports have raised concerns regarding the incorporation of nanoparticles into dental adhesive resins, because nanofilled materials displayed high viscosity and limited ability to flow into dentinal tubules [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 83%

Shear Bond Strength and Color Stability of Novel Antibacterial Nanofilled Dental Adhesive Resins

et al. 2022

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Experimental adhesives containing co-doped metaloxide nanoparticles were demonstrated to display strong and long-term antibacterial properties against Streptococcus mutans biofilms. The present study represents an effort to characterize the shear-bond strength (SBS) and color stability (CS) of these novel biomaterials. Experimental adhesives were obtained by dispersing nitrogen and fluorine co-doped titanium dioxide nanoparticles (NF_TiO2, 10%, 20% or 30%, v/v%) into OptiBond Solo Plus (OPTB). Dentin surfaces were wet-polished (600-Grit). Specimens (n = 5/group) of Tetric EvoCeram were fabricated and bonded using either OPTB or experimental (OPTB + NF_TiO2) adhesives. Specimens were stored in water (37 °C) for twenty-four hours (T1), three months (T2), and six months (T3). At T1, T2, or T3, specimens were removed from water storage and were tested for SBS. Disc-shaped specimens (n = 10/group; d = 6.0 mm, t = 0.5 mm) of adhesives investigated were fabricated and subjected to thermocycling (10,000 cycles, 5–55 °C, 15 s dwell time). Specimens’ colors were determined with a VITA EasyshadeÒ V spectrophotometer (after every 1000 cycles). SBS data was analyzed using two-way ANOVA and post-hoc Tukey tests, while CS data was analyzed using one-way ANOVA and post-hoc Tukey tests (α = 0.05). Mean values of SBS ranged from 16.39 ± 4.20 MPa (OPTB + 30%NF_TiO2) to 19.11 ± 1.11 MPa (OPTB), from 12.99 ± 2.53 MPa (OPTB + 30% NF_TiO2) to 14.87 ± 2.02 (OPTB) and from 11.37 ± 1.89 (OPTB + 20% NF_TiO2) to 14.19 ± 2.24 (OPTB) after twenty-four hours, three months, and six months of water storage, respectively. Experimental materials had SBS values that were comparable (p > 0.05) to those from OPTB independently of nanoparticle concentration or time-point considered. Experimental materials with higher NF_TiO2 concentrations had less intense color variations and were more color stable than OPTB even after 10,000 thermocycles. In combination, the results reported have demonstrated that experimental adhesives can establish strong and durable bonds to human dentin while displaying colors that are more stable, thereby suggesting that the antibacterial nanotechnology investigated can withstand the harsh conditions within the oral cavity without compromising the esthetic component of dental restorations.

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“…Sole PGLA has weak mechanical properties and cell affinity, and it is commonly preferred to be compounded together with a ceramic constituent to form a polymer/ceramic composite scaffold for tissue engineering applications. Consequently, composites with polymer matrices, including biologically active nanoparticles, have gained particular attention in the biomedical field [ 393 , 394 ].…”

Section: Am Of Biomedical Polymersmentioning

confidence: 99%

Additive Manufacturing of Biomaterials—Design Principles and Their Implementation

et al. 2022

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Additive manufacturing (AM, also known as 3D printing) is an advanced manufacturing technique that has enabled progress in the design and fabrication of customised or patient-specific (meta-)biomaterials and biomedical devices (e.g., implants, prosthetics, and orthotics) with complex internal microstructures and tuneable properties. In the past few decades, several design guidelines have been proposed for creating porous lattice structures, particularly for biomedical applications. Meanwhile, the capabilities of AM to fabricate a wide range of biomaterials, including metals and their alloys, polymers, and ceramics, have been exploited, offering unprecedented benefits to medical professionals and patients alike. In this review article, we provide an overview of the design principles that have been developed and used for the AM of biomaterials as well as those dealing with three major categories of biomaterials, i.e., metals (and their alloys), polymers, and ceramics. The design strategies can be categorised as: library-based design, topology optimisation, bio-inspired design, and meta-biomaterials. Recent developments related to the biomedical applications and fabrication methods of AM aimed at enhancing the quality of final 3D-printed biomaterials and improving their physical, mechanical, and biological characteristics are also highlighted. Finally, examples of 3D-printed biomaterials with tuned properties and functionalities are presented.

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A brief review concerning the latest advances in the influence of nanoparticle reinforcement into polymeric-matrix biomaterials

Cited by 19 publications

References 105 publications

3D Printed Poly(𝜀-caprolactone)/Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties

3D Printed Poly(𝜀-caprolactone)/Hydroxyapatite Scaffolds for Bone Tissue Engineering: A Comparative Study on a Composite Preparation by Melt Blending or Solvent Casting Techniques and the Influence of Bioceramic Content on Scaffold Properties

Shear Bond Strength and Color Stability of Novel Antibacterial Nanofilled Dental Adhesive Resins

Additive Manufacturing of Biomaterials—Design Principles and Their Implementation

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