A Brief Review on Invasive Aspergillosis and the Host Immune Response and the Target Drugs

Kizhakedathil, Moni Philip Jacob; Koppula, Aakash; Devi, C. Subathra

doi:10.2174/1871522217666170706151211

Cited by 2 publications

(5 citation statements)

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“…Aspergillus spp. are fairly hardy organisms that can grow on many carbon and nitrogen sources, are thermotolerant (37-50°C) due to ribosomal biogenesis proteins, and can withstand high osmotic pressure (Oliveira and Caramalho 2014;Jacob Kizhakedathil et al 2017). Interestingly, these microorganisms exhibit an alternative phenotype, termed "fluffy" growth, under certain stress environments.…”

Section: General Features Of Aspergillusmentioning

confidence: 99%

“…Fungal infections leading to endophthalmitis have also been reported (Vinekar et al 2014). CPA progresses slowly and is considered as the phase between invasive and noninvasive disease that can be manifested into several types: aspergilloma, chronic forms (cavitary, fibrotic, and necrotizing), and Aspergillus nodules (Jacob Kizhakedathil et al 2017). An aspergilloma is essentially a clump of Aspergillus found in a body cavity (e.g., sinus) or an organ such as the bronchi or lungs of patients suffering from tuberculosis, cancer, central nervous system diseases, hydatid disease, or other chronic infections (M'saad et al 2010;Chowdhury et al 2014;Huang et al 2017;Kumar et al 2017;McCarthy et al 2017).…”

Section: Diseases Caused By Pathogenic Aspergillusmentioning

confidence: 99%

“…CPA is often misdiagnosed as pulmonary tuberculosis. IA is frequently regarded as the most deadly form of aspergillosis, usually in the lungs and referred to as invasive pulmonary aspergillosis (Jacob Kizhakedathil et al 2017). This infection typically begins by colonizing the lungs and spreads via the bloodstream to other organs anywhere in the body.…”

Section: Diseases Caused By Pathogenic Aspergillusmentioning

confidence: 99%

“…Importantly, medical treatment options for other diseases have caused a significant increase in invasive aspergillosis (IA) cases over the past 30 years (Tekaia and Latgé 2005). Particularly, immunosuppression for organ transplants and aggressive cancer therapies can leave patients at increased risk to develop IA (Jacob Kizhakedathil et al 2017). This is a major threat to the health of some hospital patients, as the mortality rate for IA infections in 2005 was estimated to be around 60%-90%, depending on the patient's specific situation (Tekaia and Latgé 2005).…”

Section: Introductionmentioning

confidence: 99%

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The pathogenicity ofAspergillus fumigatus, drug resistance, and nanoparticle delivery

et al. 2018

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The genus Aspergillus includes fungal species that cause major health issues of significant economic importance. These microorganisms are also the culprit for production of carcinogenic aflatoxins in grain storages, contaminating crops, and economically straining the production process. Aspergillus fumigatus is a very important pathogenic species, being responsible for high human morbidity and mortality on a global basis. The prevalence of these infections in immunosuppressed individuals is on the rise, and physicians struggle with the diagnosis of these deadly pathogens. Several virulence determinants facilitate fungal invasion and evasion of the host immune response. Metabolic functions are also important for virulence and drug resistance, since they allow fungi to obtain nutrients for their own survival and growth. Following a positive diagnostic identification, mortality rates remain high due, in part, to emerging resistance to frequently used antifungal drugs. In this review, we discuss the role of the main virulence, drug target, and drug resistance determinants. We conclude with the review of new technologies being developed to treat aspergillosis. In particular, microsphere and nanoparticle delivery systems are discussed in the context of improving drug bioavailability. Aspergillus will likely continue to cause problematic infections in immunocompromised patients, so it is imperative to improve treatment options.

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Section: General Features Of Aspergillusmentioning

confidence: 99%

Section: Diseases Caused By Pathogenic Aspergillusmentioning

confidence: 99%

Section: Diseases Caused By Pathogenic Aspergillusmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The pathogenicity ofAspergillus fumigatus, drug resistance, and nanoparticle delivery

et al. 2018

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“…Sendo assim, estas são características que tornam mais fácil a sua diferenciação das outras espécies, e faz com que ele possa ser encontrado globalmente e em diversos ambientes (HAINES, 1995;SUGUI, 2013;SUGUI et al, 2014). Desse modo, a forma disseminada da doença geralmente é aguda e fatal (TAUBITZ et al, 2007;KRADIN;MARK, 2008;MCCORMICK et al, 2010;KOEHLER et al, 2014;KIZHAKEDATHIL et al,2017).…”

Section: Características Macro E Microscópicasunclassified

Expressão heteróloga em Saccharomyces cerevisiae da translocase de membrana mitocondrial externa Tom20 de Aspergillus fumigatus

Oliveira¹

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Dedico este trabalho aos meus pais, Yara C. S. Cavalcanti e João Ramos de Oliveira, por todo amor, companheirismo, apoio e cuidado. Obrigada por embarcarem comigo, com tanto amor, nessa jornada chamada vida. Vocês são meu ponto de paz e meu lar. São vocês que me dão forças todos os dias para continuar. Tudo isso é por vocês. Espero um dia orgulhá-los, assim como me orgulho de vocês, e poder retribuir tudo que fazem por mim. Amo vocês. Aos meus avós, Maria Luiza da Silva Cavalcanti, Álvaro Mendonça Cavalcanti e FranciscaMalaquias de Jesus, por sempre cuidarem de mim, e estarem ao meu lado apesar da distância física. Obrigada por me fazerem sentir amada e abraçada sempre que conversamos, e por me ensinarem tanto sobre a vida. Sou muito grata a Deus por ser sua neta e tenho muito orgulho de vocês. Amo vocês.À minha madrinha Liliane da Silva Godoy (in memoriam). Obrigada por ter existido em minha vida, por ter cuidado de mim como sua filha do coração e por ter sido minha segunda mãe. Sei que sempre estará ao meu lado e olhando por mim. Nunca te esquecerei. Saudades e amor eterno. vi AGRADECIMENTOSAo meu orientador, Prof. Dr. Sérgio Akira Uyemura, por confiar em mim e por ter aceitado me orientar. Agradeço por me receber em seu laboratório, por todos os ensinamentos e conselhos, por toda ajuda e críticas construtivas, pela paciência, empatia, e respeito. Saiba que o senhor contribuiu muito para que eu crescesse pessoalmente e profissionalmente. Vou me esforçar para ser uma profissional cada vez melhor, tendo no senhor um exemplo a ser seguido.À Profa. Dra. Taisa Magnani Dinamarco pelos ensinamentos, prontidão e colaboração na realização deste trabalho. E também a todos os membros e amigos do

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A Brief Review on Invasive Aspergillosis and the Host Immune Response and the Target Drugs

Cited by 2 publications

References 0 publications

The pathogenicity ofAspergillus fumigatus, drug resistance, and nanoparticle delivery

The pathogenicity ofAspergillus fumigatus, drug resistance, and nanoparticle delivery

Expressão heteróloga em Saccharomyces cerevisiae da translocase de membrana mitocondrial externa Tom20 de Aspergillus fumigatus

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