A brief review on the application of nanoparticle enclosed herbal medicine for the treatment of infective endocarditis

Namdari, Mehrdad; Eatemadi, Ali; Soleimaninejad, Maryam; Hammed, Aiyelabegan T.

doi:10.1016/j.biopha.2016.12.099

Cited by 68 publications

(33 citation statements)

References 94 publications

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“…It is well known that the toxicity of nanoparticles is related to size, shape, concentration. 62 Ge et al's study showed that at lower concentrations (,40 μg/mL), the cytotoxic effect of MNPs was smaller than that at high concentrations (.80 μg/mL). 63 The toxicity may be related to the reactions between nanoparticles and biological environment in the human body.…”

Section: Toxicity and Cytotoxic Effectsmentioning

confidence: 99%

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Zhang¹,

Tang²,

Liu³

et al. 2017

IJN

132

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Chemotherapy is still one of the main cancer therapy treatments, but the curative effect of chemotherapy is relatively low, as such the development of a new cancer treatment is highly desirable. The gradual maturation of nanotechnology provides an innovative perspective not only for cancer therapy but also for many other applications. There are a diverse variety of nanoparticles available, and choosing the appropriate carriers according to the demand is the key issue. The performance of nanoparticles is affected by many parameters, mainly size, shape, surface charge, and toxicity. Using nanoparticles as the carriers to realize passive targeting and active targeting can improve the efficacy of chemotherapy drugs significantly, reduce the mortality rate of cancer patients, and improve the quality of life of patients. In recent years, there has been extensive research on nanocarriers. In this review, the effects of several major parameters of nanoparticles on their physical and chemical properties are reviewed, and then the recent progress in the application of several commonly used nanoparticles is presented.

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Section: Toxicity and Cytotoxic Effectsmentioning

confidence: 99%

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Zhang¹,

Tang²,

Liu³

et al. 2017

IJN

132

View full text Add to dashboard Cite

show abstract

“…In addition, they have a high systemic clearance, therefore repeated administration and high intake doses are required. These factors result in low efficacy and limited therapeutic use (Namdari, Eatemadi, Soleimaninejad, & Hammed, 2017).…”

Section: Herbal Antifungalsmentioning

confidence: 99%

Nanotherapeutics as promising approaches to combat fungal infections

Kamel

2019

Drug Development Research

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Fungal infections are a serious and growing public health problem. Invasive fungal infections can increase the rate of morbidity and mortality of immune-compromised patients. Nowadays, there are a great number of antifungal agents; however, the control of fungal diseases is unsatisfactory due to lack of treatment efficiency, low drug biovailability, high drug toxicity, and emergence of fungal resistance. The use of advanced drug delivery systems can hopefully revolutionize the treatment of fungal diseases. This article comprises an overview on antifungal drugs, plant-derived moieties with antifungal activity, together with the encountered problems. The nanoencapsulation of antifungal agents is proposed as a potential successful therapeutic approach by enhancing the solubility and stability of the active constituents, extending the biological effect, improving the absorption, and adjusting the degree of hydrophilicity/lipophilicity. In addition, some antifungal market products based on the nanotechnology are displayed. K E Y W O R D Sdrugs, efficacy and safety, fungal, herbal, nanoparticles

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“…This work aimed at encapsulating the phenolic compounds into nanoparticles by self-assembly method for the improvement of bioavailability and the applications of food industry. compounds (McClements, 2017;Namdari, Eatemadi, Soleimaninejad, & Hammed, 2017;Santos, Ponte, Boonme, Silva, & Souto, 2013).…”

Section: Practical Applicationsmentioning

confidence: 99%

“…However, the phenolic compounds, as the natural extracts, are susceptible to environmental factors such as light, oxidant, metal ions, and heat, which can reduce their stability and biological efficiency. Nanoencapsulation technology is a promising approach to solve these problems and also can mask the unpleasant taste of the phenolic compounds (McClements, ; Namdari, Eatemadi, Soleimaninejad, & Hammed, ; Santos, Ponte, Boonme, Silva, & Souto, ).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles based on sodium alginate and β-conglycinin: Self-assembly and delivery of Phyllanthus urinaria phenolic compounds

Liu

Liao

Wei

et al. 2018

J Food Process Preserv

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Nanoparticles based on sodium alginate (SA) and β‐conglycinin (7S) were self‐assembled according to the electrostatic interaction principle. The self‐assembly parameters optimized by response surface methodology were total concentration of 7S and SA of 6.0 mg/ml, 7S to SA mass ratio of 1.85:1, and pH of 2.5. Phyllanthus urinaria phenolic compounds were loaded into the nanoparticles according to the optimized parameters. The phenolic compounds‐loaded nanoparticles characterized by scanning electron microscopy and particle size analyzer showed that they had a spherical shape with the average size was around 125 nm. Infrared spectroscopy analyses indicated that there were intramolecular hydrogen bonds in the nanoparticles, and the phenolic compounds were successfully encapsulated. The phenolic compounds released from the nanoparticles had good antioxidant activity, and their cumulative release percentage at pH 7.4 was higher than that at pH 1.2. The release kinetics of phenolic compounds showed a pH‐dependent release profile and a Fickian diffusion mechanism. Practical applications Phenolic compounds from Phyllanthus urinaria have excellent bioactivities and have been proven that there are numerous benefits for body. However, the applications of the phenolic compounds are limited because of their chemical instability against environmental conditions. Nanoencapsulation technology is a promising approach to solve this problem. This work aimed at encapsulating the phenolic compounds into nanoparticles by self‐assembly method for the improvement of bioavailability and the applications of food industry.

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A brief review on the application of nanoparticle enclosed herbal medicine for the treatment of infective endocarditis

Cited by 68 publications

References 94 publications

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Effects of major parameters of nanoparticles on their physical and chemical properties and recent application of nanodrug delivery system in targeted chemotherapy

Nanotherapeutics as promising approaches to combat fungal infections

Nanoparticles based on sodium alginate and β-conglycinin: Self-assembly and delivery of Phyllanthus urinaria phenolic compounds

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