Substance use disorders (SUDs) have reached epidemic proportions in the United States. The focus on the bad news related to SUDs can lead to a sense of hopelessness for nurses about identifying and managing these disorders. What is not as widely known is that there have been advances in several areas related to SUDs. This good news includes growing science about the neurobiology of these disorders and approaches to reduce stigma. In addition, there are known factors to improve success in recovery, such as improved quality of life, self-efficacy, and spirituality. Evidence-based treatments are also available for SUDs, including medications. Nurses should be aware of this good news about SUDs to maintain hope and integrate this knowledge into their practice. [Journal of Psychosocial Nursing and Mental Health Services, 55(3), 24-28.].