A bright chemiluminescence conjugated polymer–mesoporous silica nanoprobe for imaging of colonic tumors <i>in vivo</i>

Li, Yukun; Zhu, Beibei; Han, Wanying; Tang, Wei; Duan, Xinrui

doi:10.1039/d2an00294a

Cited by 7 publications

(4 citation statements)

References 54 publications

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“…Recently, the hypochlorite anion (ClO − ) as a significant colonic cancer marker was detected and visualized by the development of a new CL probe. 72 Li and co-workers fabricated poly[(9,9-di(2-ethylhexyl)-9H-fluorene-2,7-vinylene)-co-(1-methoxy-4-(2-ethylhexyloxy)-2,5-phenylenevinylene)] (PFV-co-MEHPV, namely, CP1), and then it was captured into MSNs. After that, the asprepared nanoparticles were premodified with polyphenylenevinylene (PPV) via in situ polymerization to make bright PPV@MSN-CP1 nanoparticles.…”

Section: Nanomaterials-based CL Probesmentioning

confidence: 99%

“…The liver cancer biomarker alkaline phosphatase can specifically hydrolyze these NPs, enabling liver cancer-targeting CL. Recently, the hypochlorite anion (ClO – ) as a significant colonic cancer marker was detected and visualized by the development of a new CL probe . Li and co-workers fabricated poly[(9,9-di(2-ethylhexyl)-9 H -fluorene-2,7-vinylene)- co -(1-methoxy-4-(2-ethylhexyloxy)-2,5-phenylenevinylene)] (PFV- co -MEHPV, namely, CP1), and then it was captured into MSNs.…”

Section: Imaging Applicationsmentioning

confidence: 99%

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Recent Applications and Future Perspectives of Chemiluminescent and Bioluminescent Imaging Technologies

Mostafa

Abdussalam

Zholudov

et al. 2023

Chemical & Biomedical Imaging

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Imaging technologies based on chemiluminescence (CL) and bioluminescence (BL) have seen a tremendous growth in the past decade due to their extensive contributions to biochemical analysis and biomedical science. CL and BL imaging technologies have many advantages over commonly used imaging techniques (such as fluorescence and electrochemical systems). CL and BL proceed without an external light source, thus avoiding photobleaching, high interference of background signal, and autofluorescence. Furthermore, CL and BL analytical techniques are characterized by their low detection limit, high selectivity, short assay time, and simple instrumentation. Recently, CL-based imaging technology has been applied successfully for the determination and in vivo imaging of several significant analytes. Meanwhile, an innovative BL imaging technology has been established for the noninvasive real-time tracking of different biomolecules relying on the interaction between luciferase and its substrate. In the current review, we discuss the recent applications of CL and BL imaging approaches over the past five years. Finally, we also discuss the current state of progress and the prospects for CL and BL imaging systems.

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Section: Nanomaterials-based CL Probesmentioning

confidence: 99%

Section: Imaging Applicationsmentioning

confidence: 99%

Recent Applications and Future Perspectives of Chemiluminescent and Bioluminescent Imaging Technologies

Mostafa

Abdussalam

Zholudov

et al. 2023

Chemical & Biomedical Imaging

View full text Add to dashboard Cite

show abstract

“…The advantages of π-conjugated materials lie in their large surface area, tunable optical properties, and good biocompatibility (Li et al, 2022b). These characteristics make them effective drug carriers that can achieve targeted drug delivery through surface modification.…”

Section: Advances In Nanomedicine Delivery Systemsmentioning

confidence: 99%

Nanotechnology for brain tumor imaging and therapy based on π-conjugated materials: state-of-the-art advances and prospects

Sun,

Wang,

Tian

et al. 2023

Front. Chem.

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In contemporary biomedical research, the development of nanotechnology has brought forth numerous possibilities for brain tumor imaging and therapy. Among these, π-conjugated materials have garnered significant attention as a special class of nanomaterials in brain tumor-related studies. With their excellent optical and electronic properties, π-conjugated materials can be tailored in structure and nature to facilitate applications in multimodal imaging, nano-drug delivery, photothermal therapy, and other related fields. This review focuses on presenting the cutting-edge advances and application prospects of π-conjugated materials in brain tumor imaging and therapeutic nanotechnology.

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“…MSN has also been developed to load CPs for in vitro and in vivo detection of ClO − activity. Recently, Li et al encapsulated CP (CP1) in polystyrene (PPV) pre-modified MSN, resulting in the construction of luminous PPV@MSN-CP1 nanoparticles which were employed for the detection of ClO − in tumor imaging [78]. The mechanism of luminescence of the nanoparticles (PPV@MSN-CP1) is the oxidation of the vinylidene bond of CP1 by hypochlorite via π 2 -π 2 cycloaddition, followed by the formation of a PPV-dioxetane intermediate to generate photons.…”

Section: Hclo/clo −mentioning

confidence: 99%

Recent Advances in Nanomaterial-Based Chemiluminescence Probes for Biosensing and Imaging of Reactive Oxygen Species

Huang

Zhou

et al. 2023

Nanomaterials

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Reactive oxygen species (ROS) play important roles in organisms and are closely related to various physiological and pathological processes. Due to the short lifetime and easy transformation of ROS, the determination of ROS content in biosystem has always been a challenging task. Chemiluminescence (CL) analysis has been widely used in the detection of ROS due to its advantages of high sensitivity, good selectivity and no background signal, among which nanomaterial-related CL probes are rapidly developing. In this review, the roles of nanomaterials in CL systems are summarized, mainly including their roles as catalysts, emitters, and carriers. The nanomaterial-based CL probes for biosensing and bioimaging of ROS developed in the past five years are reviewed. We expect that this review will provide guidance for the design and development of nanomaterial-based CL probes and facilitate the wider application of CL analysis in ROS sensing and imaging in biological systems.

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A bright chemiluminescence conjugated polymer–mesoporous silica nanoprobe for imaging of colonic tumors in vivo

Abstract: Hypochlorite acid (ClO-) is one of the major reactive oxygen species (ROS) in colon cancer providing an effective target for the colonic tumor in vivo imaging. For detection of ClO-...

Cited by 7 publications

References 54 publications

Recent Applications and Future Perspectives of Chemiluminescent and Bioluminescent Imaging Technologies

Recent Applications and Future Perspectives of Chemiluminescent and Bioluminescent Imaging Technologies

Nanotechnology for brain tumor imaging and therapy based on π-conjugated materials: state-of-the-art advances and prospects

Recent Advances in Nanomaterial-Based Chemiluminescence Probes for Biosensing and Imaging of Reactive Oxygen Species

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