We propose a hybrid full duplex passive optical network with fusion of wavelength‐division‐multiplexing and orthogonal frequency‐division multiplexing (WDM‐OFDM) for a radio‐over‐fiber (RoF) system application. The key of the system is a tunable optical frequency comb (OFC) embedded cascading modulators and a parameter mixer. Moreover, 23 frequency components with 0.6 dB flatness generated by the OFC are used as light sources for each WDM channel. We utilize a 7.5 GHz OFDM wired signal and a 12.5 GHz OFDM wireless signal for downstream transmission and 10 Gb/s OOK (on–off keyed) signals for upstream traffic. Using polarization multiplexing technique, we extract a central optical carrier to bear the upstream signal so that no excess optical source is introduced into the ONU. Thus, the intricacy and costs of system are diminished. Moreover, successful transmission has been demonstrated since the bit error rates of the downstream and upstream signals are always under the adopted forward error correction limit. Furthermore, the proposed system can enhance power budget and reduce cost, which has a promising prospect for future wireless communication.