A/C1166 Gene Polymorphism of the Angiotensin II Type 1 Receptor (AT1) and Ambulatory Blood Pressure: The Ohasama Study.

Kikuya, Masahiro; Sugimoto, Ken; Katsuya, Tomohiro; Suzuki, Michiko; Satō, Tomomi; Funahashi, Jin; Katoh, Ryusuke; Kazama, Itsuro; Michimata, Mari; Araki, Tsutomu; Hozawa, Atsushi; Tsuji, Ichiro; Ogihara, Toshio; Yanagisawa, Teruyuki; Imai, Yutaka; Matsubara, Mitsunobu

doi:10.1291/hypres.26.141

Cited by 45 publications

(32 citation statements)

References 21 publications

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“…The interplay between environmental and genetic factors is a major determinant of the final phenotype in hypertension [2]. Several genes: angiotensinogen gene (AGT), angiotensin I-converting enzyme (ACE), angiotensin II type 1-receptor (AT1-R) and angiotensin II type 2-receptor (AT2-R) have been reported an association with hypertension [7][8][9][10][11]. ACE is the major enzyme of the reninangiotensin-aldosterone system (RAAS), functions conversion of angiotensin I to angiotensin II which binds to plasma membrane receptors, producing arteriolar constriction and a rise in systolic and diastolic blood pressure.…”

Section: Introductionmentioning

confidence: 99%

Association of High Altitude Hypertension with Angiotensin Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism

Ch¹,

Doza²,

Kumar³

2017

UNOAJ

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The study included ACE gene I/D polymorphism and its association between high altitude hypertension. Genetic, biochemical, anthropometric and Physiometeric results were analyzed using statistical software. The results were non-significant for I/D polymorphism.Objective: ACE is the major enzyme of hypertension and with most commonly reviewed I/D polymorphism. High-altitude exposes various physiological and biochemical changes, which contributes a rise in systemic blood pressure of the body. There are very few studies available in North-India, with a core focus on the high altitude hypertension. Therefore, a current study supported an interest to find out the association of high altitude hypertension with ACE gene I/D polymorphism.Methods: to study the significant association with respect to altitude, genetic, biochemical, anthropometric and physio-metric comparison were conducted among 98 individuals where 489nbeing hypertensive patients and other half being normotensive, inclusive of both males and females. The entire results were finally examined and analyzed using statistical software SPSS 16.0 version. Results:According to study results, mean arterial blood pressure and triglycerides were significantly (p<0.05) associated with SBP among both hypertensive and normotensives. Whereas HDL, LDL-HDL ratio, CHO-HDL were significantly associated only among hypertensive, and age, PP, and SpO2 have been significantly (p<0.05) associated with SBP among normotensive, a strong predictor for SBP. Conclusion:The genotypic observations were visibly linked with the disease, however, the results were statistically non-significant (ID/DD vs. II; OR: 0.54, 95% CI: 0.20-1.44, p= 0.217). A further study with considerate knowledge of noteworthy dynamics, mainly, altitude, population size, and ethnicity are recommended.

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Section: Introductionmentioning

confidence: 99%

Association of High Altitude Hypertension with Angiotensin Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism

Ch¹,

Doza²,

Kumar³

2017

UNOAJ

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“…Genetic factors are likely to be involved in this difference in response (6,7). The renin-angiotensin-aldosterone system (RAAS), which has a central role in the maintenance of body fluid and blood pressure, is involved in the development of hypertension, and several genes in this system, such as the angiotensinogen (AGT), angiotensin I-converting enzyme (ACE), angiotensin II type 1 receptor (AT1-R) and angiotensin II type 2 receptor (AT2-R) genes, have been reported to have an association with hypertension (8)(9)(10)(11)(12). ACE is the key enzyme of the RAAS, and its insertion-deletion polymorphism (ACE I/D) in intron 16 is the most studied polymorphism in the RAAS.…”

Section: Introductionmentioning

confidence: 99%

Interaction of Angiotensin I-Converting Enzyme Insertion-Deletion Polymorphism and Daily Salt Intake Influences Hypertension in Japanese Men

et al. 2006

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“…27 Genetic polymorphisms and diurnal BP variation Daytime SBP and diastolic blood pressure (DBP) values were higher in individuals with the C allele in the angiotensin II type 1 receptor gene A/C 1166 polymorphism (130.5 ± 14.0/77.4 ± 8.3 mm Hg) than in those with the AA genotype (127.7 ± 13.6/75.8 ± 8.3 mm Hg, P¼0.03/0.04), although the difference was not statistically significant after adjusting for age, gender, body mass index and smoking status. 28 Nighttime BP values were significantly lower among individuals with the MM genotype in the angiotensinogen M235T polymorphism than in those with the T allele (105.2±13.0/60.1±6.9 vs. 110.6±13.3/ 63.6 ± 7.8 mm Hg, P¼0.04/0.02). The nocturnal decline in BP was significantly larger among those with the MM genotype than with the T allele (17.4/19.8 vs. 13.5/16.2 mm Hg, P¼0.004/0.01).…”

Section: Diurnal Bp Variation and Target-organ Damagementioning

confidence: 84%

Diurnal blood pressure variation and cardiovascular prognosis in a community-based study of Ohasama, Japan

Metoki

Imai

2010

Hypertens Res

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The introduction of 24-h ambulatory blood pressure (BP) monitoring has enabled BP evaluations at specific times of the day. Associations between diurnal BP variation and cardiovascular prognosis have been investigated in the Ohasama study, which is an epidemiological survey of hypertension using ambulatory and home BP monitoring that has been ongoing since 1985 in the general population of Ohasama, a town located in northern Japan. A diminished nocturnal decline in systolic BP was associated with a greater common carotid intima-media thickness as well as a higher risk of cardiovascular morbidity and mortality, especially the risk for cerebral infarction. The consumption of large amounts of alcohol was associated with a higher morning pressor surge. A large nocturnal decline in BP and a large morning pressor surge were both associated with a risk of cerebral hemorrhage. Ambulatory BP monitoring provides not only static, but also dynamic information about BP that should be considered to ensure effective management of hypertension and cardiovascular diseases.

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A/C1166 Gene Polymorphism of the Angiotensin II Type 1 Receptor (AT1) and Ambulatory Blood Pressure: The Ohasama Study.

Abstract: We previously investigated the relation between hypertension and each of three major genetic polymorphisms in the renin-angiotensin (AGT)-aldosterone system (R-

Cited by 45 publications

References 21 publications

Association of High Altitude Hypertension with Angiotensin Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism

Association of High Altitude Hypertension with Angiotensin Converting Enzyme (ACE) Gene Insertion/Deletion Polymorphism

Interaction of Angiotensin I-Converting Enzyme Insertion-Deletion Polymorphism and Daily Salt Intake Influences Hypertension in Japanese Men

Diurnal blood pressure variation and cardiovascular prognosis in a community-based study of Ohasama, Japan

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