A candidate reference method for serum calcium measurement by inductively coupled plasma mass spectrometry

Yan, Ying; Ge, Menglei; Ma, Rong; Zhao, Haijian; Wang, Donghuan; Hu, Cuihua; Wang, Jing; Chen, Wenxiang; Zhang, Chuanbao

doi:10.1016/j.cca.2016.07.004

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…These conflicting results might be attributed to the differences in observational study characteristics, sample size, adjustment of confounders, stroke subtype, serum calcium levels, and their measurement method and whether calcium was corrected or not. In this study, the ICP-MS method, a new elemental analysis technique, may be used as a candidate reference method for the standardization of serum calcium determination (16). Compared with the traditional colorimetric method (12, 13, 21) or enzymatic method ( 14) used in the above contradictory studies, the ICP-MS method not only can simultaneously measure multiple elements but also has higher sensitivity and wider limits of detection (24).…”

Section: Figurementioning

confidence: 99%

Association between serum calcium levels and first stroke: A community-based nested case-control study

Ding

Lin

et al. 2022

Front. Neurol.

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BackgroundEvidence from epidemiologic studies has been limited and inconsistent regarding the role of serum calcium in stroke incidence risk. We aimed to evaluate the association between serum albumin-corrected calcium and the risk of the first stroke in the Chinese community-dwelling population.MethodsThe study sample population was drawn from the “H-type Hypertension and Stroke Prevention and Control Project.” Using a nested case-control study, a total of 1,255 first-stroke cases and 1,255 controls matched for age, sex, and village were included in the final data analysis. We measured the serum calcium by inductively coupled plasma mass spectrometry and assessed the associations between serum albumin-corrected calcium and first stroke using conditional logistic regression.ResultsThe overall mean (SD) serum albumin-corrected calcium was 8.9 (0.6) mg/dl. Compared with the middle tertile (8.7–9.1 mg/dl), the multivariate-adjusted odds ratios (95% CIs) of first total stroke associated with the lowest tertile and the highest tertile of serum albumin-corrected calcium were 1.37 (1.10, 1.70) and 1.30 (1.04, 1.62), respectively. Similar trends were observed for the first ischemic stroke. Consistently, restricted cubic spline showed a U-shaped association between serum albumin-corrected calcium and risk of total stroke and ischemic stroke. However, serum albumin-corrected calcium had no significant effect on first hemorrhagic stroke. No significant effect modification was observed in the subgroup analysis.ConclusionsOur results suggested a U-shaped association between serum calcium and first stroke; both low and high serum calcium levels were associated with an increased risk of the first stroke in the Chinese population.

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Section: Figurementioning

confidence: 99%

Association between serum calcium levels and first stroke: A community-based nested case-control study

Ding

Lin

et al. 2022

Front. Neurol.

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“…A recent interesting study shows that strong acridinium esters ECL is observed in neutral solutions when a positive voltage over 2.0 V (versus Ag/AgCl) is applied to the platinum working electrode. The use of neutral solution can avoid the unfavourable conversion of the acridinium ester to its inactive pseudobase, enabling sensitive detection of acridinium ester with a limit of detection of 0.16 ng/ml and facilitating its application in bioanalysis .…”

Section: Ecl Of Acridinium Estersmentioning

confidence: 99%

Electrochemiluminescence of Acridines

et al. 2016

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Acridines play an important role in various fields of sciences. Besides their application for treatment of a number of infections, cancer, viral and prion diseases, they have been extensively used in chemiluminescence. Electrochemiluminescence (ECL) is a unique kind of chemiluminescence with the precise temporal and spatial control of light emitting reactions by utilizing electrochemistry techniques. These advantages result in increasing attention towards acridines ECL. This review summarizes acridines used in ECL, ECL mechanisms, strategies for increasing ECL intensities, and ECL analytical applications, as well as prospects the future development of acridine ECL.

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Serum calcium determination with atomic absorption spectrophotometry and colorimetric method: association and predictive equations between them in cattle and sheep samples

et al. 2020

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A candidate reference method for serum calcium measurement by inductively coupled plasma mass spectrometry

Cited by 10 publications

References 13 publications

Association between serum calcium levels and first stroke: A community-based nested case-control study

Association between serum calcium levels and first stroke: A community-based nested case-control study

Electrochemiluminescence of Acridines

Serum calcium determination with atomic absorption spectrophotometry and colorimetric method: association and predictive equations between them in cattle and sheep samples

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