2023
DOI: 10.1088/1742-6596/2420/1/012097
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A carbon minibeam irradiation facility concept

Abstract: In minibeam therapy, the sparing of deep-seated normal tissue is limited by transverse beam spread caused by small-angle scattering. Contrary to proton minibeams, helium or carbon minibeams experience less deflection, which potentially reduces side effects. To verify this potential, an irradiation facility for preclinical and clinical studies is needed. This manuscript presents a concept for a carbon minibeam irradiation facility based on a LINAC design for conventional carbon therapy. A quadrupole triplet foc… Show more

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Cited by 1 publication
(2 citation statements)
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“…In general, the sensitivity of the MBC to setup uncertainties renders MBCs an inferior choice for iMBRT generation when compared to beam focusing methods [13,35]. However, since no contemporary clinical carbon ion therapy facility has access to the required beam optics to achieve the desired minibeam widths, pre-clinical experiments need to rely on MBCs as a more practical option.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In general, the sensitivity of the MBC to setup uncertainties renders MBCs an inferior choice for iMBRT generation when compared to beam focusing methods [13,35]. However, since no contemporary clinical carbon ion therapy facility has access to the required beam optics to achieve the desired minibeam widths, pre-clinical experiments need to rely on MBCs as a more practical option.…”
Section: Discussionmentioning
confidence: 99%
“…iMBRT in general can be accomplished with similar infrastructure to proton minibeam therapy, either by placing a minibeam collimator (MBC) in front of the patient [8] or by magnetically focusing the beam to achieve the desired sub-millimeter beam width [13]. While magnetically focused medical carbon ion beams would be the more elegant solution compared to collimators, such beams are not yet available.…”
Section: Introductionmentioning
confidence: 99%