A carrier for clinical use of recombinant human BMP-2: dehydrothermally cross-linked composite of fibrillar and denatured atelocollagen sponge

Omura, Susumu; Mizuki, Nobuyuki; Kawabe, Ryoichi; Ota, Satoshi; Kobayashi, Shigeru; Fujita, Kiyohide

doi:10.1016/s0901-5027(98)80312-3

Cited by 32 publications

(17 citation statements)

References 16 publications

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“…A BMP carrier should be nontoxic, biodegradable and conveniently sterilizable 20 . ACS appears to be particularly promising as a biomaterial for the transport of BMP 17,19,21 .…”

Section: Discussionmentioning

confidence: 99%

Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study

Alam

Ueki

Nakagawa

et al. 2009

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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Objectives: The purpose of this study was to investigate bone morphogenetic protein (BMP)-2 expression following implantation of a statin and recombinant human BMP-2 (rhBMP-2), and to compare the bone regeneration capability of these substances in the rabbit nasal bone using immunohistological methods. Study design:Twelve adult male Japanese white rabbits (n = 12, age: 12-16 weeks, weight: 2.5-3.0 kg) were divided into three experimental groups and one control group.A total of 48 bone defects, four per rabbit, were created in the nasal bone while preserving the nasal membrane. In the experimental groups, one group was implanted with 10 mg statin dissolved in 0.2 ml water with an atelocollagen sponge (ACS), the second group was implanted with 5 μg rhBMP-2 with an ACS, and in the third group only the ACS was implanted. No material was implanted in the control group.Animals were killed at 1-, 2-, and 4-weeks postoperatively. The parts that had been operated on were removed and prepared for histological assessment. The expression of BMP-2 was evaluated using immunohistochemistry, and double-immunostaining for BMP-2 and Ki67 was observed by fluorescent microscopy.2

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“…A BMP carrier should be nontoxic, biodegradable and conveniently sterilizable 20 . ACS appears to be particularly promising as a biomaterial for the transport of BMP 17,19,21 .…”

Section: Discussionmentioning

confidence: 99%

Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study

Alam

Ueki

Nakagawa

et al. 2009

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, an

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“…rh-BMP2 delivered by implantation or gene therapy induces ectopic bone formation at subcutaneous, intramuscle and intrafatty sites 13,15,18 . This ectopically-formed bone induced by rh-BMP2 exhibits the structure of porous bone or lamellar bone, and its interior occasionally contains bone marrow or fatty marrow 12,16 . In this study, the structure of TEB consisted of lamellar bone in the marginal layer and bone marrow or fatty marrow in the core.…”

Section: Discussionmentioning

confidence: 99%

rh-BMP2-induced ectopic bone for grafting critical size defects: a preliminary histological evaluation in rat calvariae

Inoda

Yamamoto

Hattori

2007

International Journal of Oral and Maxillofacial Surgery

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“…The inclusion of 10% HAC in FC-HAC enables infiltration of fibroblasts to be induced and the sponge-like structure to be maintained 7,8) .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Tooth Extraction Wound Protection Made of Atelocollagen Sponge (TRE-641): A Pilot Study in Dogs

Hirota

Mizuki

Aoki

et al. 2009

J. Hard Tissue Biology.

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Abstract:To evaluate the efficacy of tooth extraction wound protection made of atelocollagen sponge (TRE-641), we observed healing in tooth extraction sites filled with TRE-641 and those filled with a control material, oxide cellulose. Subjects were 11 beagle dogs, with a total of 22 extraction sites. Both maxillary lateral incisors were carefully removed, and extraction wounds were filled with TRE-641 on one side and with oxidized cellulose sponge as control on the other side. Wound healing was observed, and the animals were sacrificed at 7, 14, and 28 days after surgery. We compared extent of bone formation, hematoma, inflammation, and graft material remaining between the two groups. At 7 days, newly formed bone extending from the floor and wall of the socket bone were seen in the TRE-641. Hematoma and inflammation were observed in the oxide cellulose. At 14 days, a small amount of TRE-641 remained. In the oxide cellulose group, a small amount of hematoma remained. At 28 days, the extraction socket was filled with newly formed bone in both groups. TRE-641 produced acceptable early phase bone healing at the tooth extraction site with no remnant graft material with sufficient bone formation of the tooth extraction wound.

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A carrier for clinical use of recombinant human BMP-2: dehydrothermally cross-linked composite of fibrillar and denatured atelocollagen sponge

Cited by 32 publications

References 16 publications

Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study

Statin-induced bone morphogenetic protein (BMP) 2 expression during bone regeneration: an immunohistochemical study

rh-BMP2-induced ectopic bone for grafting critical size defects: a preliminary histological evaluation in rat calvariae

Efficacy of Tooth Extraction Wound Protection Made of Atelocollagen Sponge (TRE-641): A Pilot Study in Dogs

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