A carrier-free multifunctional nano photosensitizer based on self-assembly of lactose-conjugated BODIPY for enhanced anti-tumor efficacy of dual phototherapy

Nanococktail Based on Supramolecular Glyco-Assembly for Eradicating Tumors In Vivo

“…We used 1 instead of BSL-1 to determine the 1 O 2 generation of BSL-1 treated with GSH, eliminating the effect of residual GSH on the amount of 1 O 2 . 60 As shown in Figure S12, except for DPBF itself, the absorption of DPBF at 422 nm in all experimental groups exhibited a decrease, which indicates the generation of 1 O 2 . MB as reference ( 1 O 2 quantum yields Φ = 0.52 in water), the 1 O 2 quantum yields (Φ) of 1, and BSL-1 were calculated to be 0.317 and 0.183, respectively (Figure 1e).…”

“…Schematic Illustration of Nanococktail ADB Constructed by Supramolecular Self-Assembly of BSL-1, ATO, and 17-DMAG for Tumor Selectivity and Enhanced Synergic PDT and PTT during Hypoxia responsive disulfide bond), that can self-assemble into NPS for synergistic cancer PDT and PTT. 60 On the basis of analogous strategies for carrier-free multifunctional NPSs, cocktails of photosensitizer with dual inhibitors can be constructed by the simple loading of inhibitors into NPS.…”

“…Compound 1 (BODIPY), SS (monoalkyne-substituted 2,2′-dithiodiethanol) and LAC (a lactose azide derivative) were synthesized according to previous procedures. 60 As shown in Figure S1, compound 9, a BODIPY derivative with one alkyne functional group linked by one disulfide bond, was synthesized in 44.2% yield by a one pot reaction of 1 and SS. Thereafter, BSL-1 was prepared by the CuAAC reaction of LAC and 9 in 76.5% yield.…”

Recent advances in redox-responsive nanoparticles for combined cancer therapy

“…In order to solve these problems, carrier-free nanosystems based on the self-assembly of amphiphilic small molecules have been developed. 85,86 Pei and co-workers 87 synthesized amphiphilic small molecules consisting of a hydrophobic photosensitizer and a hydrophilic lactose, which was linked by GSH-responsive disulfide bonds (Fig. 2a).…”

Cancer‐Mitochondria Dual‐Targeting Glycol/Ferrocenium‐Based Polydopamine Nanoparticles for Synergistic Photothermal and Photodynamic Therapy

“…[25] For instance, the membrane of human hepatoma (HepG2) cells express galectins (lactose and galactose receptor) at a high level, which can be targeted by lactose or galactose due to the specific carbohydrate-protein interaction. [25,30,31] Subcellular targeting, differing from cancer targeting, mainly targets organelles, such as mitochondria, lysosomes, and nuclei. [18] In various cases, mitochondrion, the powerhouse of cells, given its vital function in energy supply and cell growth, has been utilized as an attractive target on organelle level to produce lethal damage precisely, especially in PDT.…”