A cascade Fermat spiral microfluidic mixer chip for accurate detection and logic discrimination of cancer cells

Zeng, Shiyu; Sun, Xiuzhu; Wan, Xinhua; Qian, Changcheng; Yue, Wenkai; Sohan, A S M Muhtasim Fuad; Lin, Xiaodong; Yin, Binfeng

doi:10.1039/d2an00689h

Cited by 10 publications

(6 citation statements)

References 42 publications

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“…Microfluidic technology is a scientific technology to control and operate fluids in micron-scale chip space, which has the advantages of low cost, simple operation, and high precision [34][35][36][37][38]. At present, microfluidic technology is commonly used to prepare small-volume Janus droplets composed of two or more materials with different chemical properties and physical structures.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Preparation and Analysis of Structured Color Janus Droplets Based on Microfluidic 3D Droplet Printing

Wu,

Jia,

Almuaalemi

et al. 2023

Micromachines

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The microfluidic technique for the three-dimensional (3D) printing of Janus droplets offers precise control over their size, orientation, and positioning. The proposed approach investigates the impact of variables such as the volume ratio of the oil phase, droplet size, and the ratio of nonionic surfactants on the dimensions of the structured color apertures of Janus droplets. The findings reveal that structured color apertures modulate accurately. Furthermore, fabricating color patterns facilitates cat, fish, and various other specific shapes using structured color Janus droplets. The color patterns exhibit temperature-sensitive properties, enabling them to transition between display and concealed states. Herein, the adopted microfluidic technique creates Janus droplets with customizable characteristics and uniform size, solving orientation as well as space arrangement problems. This approach holds promising applications for optical devices, sensors, and biomimetic systems.

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Section: Introductionmentioning

confidence: 99%

RETRACTED: Preparation and Analysis of Structured Color Janus Droplets Based on Microfluidic 3D Droplet Printing

Wu,

Jia,

Almuaalemi

et al. 2023

Micromachines

Self Cite

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“…Similarly, other groups have designed microfluidic devices to capture and sense known proteins, biomarkers, and viruses such as HPVs to diagnose HNCs [62][63][64][65]. These microfluidic POC devices can be optimized and continuously customized as required, and can be translated to clinical setups thereby assisting in early diagnosis, predicting prognosis, and helping in precision clinical management [66,67]. Common biosensing strategies used in these devices can be categorized into three major groups based on their detection principle: electrochemical, optical, and mechanical sensing [68].…”

Section: Microfluidics a Peephole Into Precision Oncologymentioning

confidence: 99%

Mapping the Potential of Microfluidics in Early Diagnosis and Personalized Treatment of Head and Neck Cancers

Pillai,

Kwan,

Yaziji

et al. 2023

Cancers

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Head and neck cancers (HNCs) account for ~4% of all cancers in North America and encompass cancers affecting the oral cavity, pharynx, larynx, sinuses, nasal cavity, and salivary glands. The anatomical complexity of the head and neck region, characterized by highly perfused and innervated structures, presents challenges in the early diagnosis and treatment of these cancers. The utilization of sub-microliter volumes and the unique phenomenon associated with microscale fluid dynamics have facilitated the development of microfluidic platforms for studying complex biological systems. The advent of on-chip microfluidics has significantly impacted the diagnosis and treatment strategies of HNC. Sensor-based microfluidics and point-of-care devices have improved the detection and monitoring of cancer biomarkers using biological specimens like saliva, urine, blood, and serum. Additionally, tumor-on-a-chip platforms have allowed the creation of patient-specific cancer models on a chip, enabling the development of personalized treatments through high-throughput screening of drugs. In this review, we first focus on how microfluidics enable the development of an enhanced, functional drug screening process for targeted treatment in HNCs. We then discuss current advances in microfluidic platforms for biomarker sensing and early detection, followed by on-chip modeling of HNC to evaluate treatment response. Finally, we address the practical challenges that hinder the clinical translation of these microfluidic advances.

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“…The most recent developments in the field include the emergence of lab-on-chip (LoC) and micro-total analysis system (µ-TAS) devices [15][16][17] and point-of-care testing systems [18][19][20], which offer exceptional efficiency in terms of convenience, analysis speed, and sample utilization. They have proven to be vital and valuable inventions in the fields of micro-engineering, bioengineering, and genetics.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Mixing: A Physics-Oriented Review

Saravanakumar,

Cicek

2023

Micromachines

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This comprehensive review paper focuses on the intricate physics of microfluidics and their application in micromixing techniques. Various methods for enhancing mixing in microchannels are explored, with a keen emphasis on the underlying fluid dynamics principles. Geometrical micromixers employ complex channel designs to induce fluid–fluid interface distortions, yielding efficient mixing while retaining manufacturing simplicity. These methods synergize effectively with external techniques, showcasing promising potential. Electrohydrodynamics harnesses electrokinetic phenomena like electroosmosis, electrophoresis, and electrothermal effects. These methods offer dynamic control over mixing parameters via applied voltage, frequency, and electrode positioning, although power consumption and heating can be drawbacks. Acoustofluidics leverages acoustic waves to drive microstreaming, offering localized yet far-reaching effects. Magnetohydrodynamics, though limited in applicability to certain fluids, showcases potential by utilizing magnetic fields to propel mixing. Selecting an approach hinges on trade-offs among complexity, efficiency, and compatibility with fluid properties. Understanding the physics of fluid behavior and rationalizing these techniques aids in tailoring the most suitable micromixing solution. In a rapidly advancing field, this paper provides a consolidated understanding of these techniques, facilitating the informed choice of approach for specific microfluidic mixing needs.

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A cascade Fermat spiral microfluidic mixer chip for accurate detection and logic discrimination of cancer cells

Abstract: Since cancer has emerged as one of the most serious threats to human health, the highly sensitive determination of cancer cells is of significant importance to improve the accuracy of...

Cited by 10 publications

References 42 publications

RETRACTED: Preparation and Analysis of Structured Color Janus Droplets Based on Microfluidic 3D Droplet Printing

RETRACTED: Preparation and Analysis of Structured Color Janus Droplets Based on Microfluidic 3D Droplet Printing

Mapping the Potential of Microfluidics in Early Diagnosis and Personalized Treatment of Head and Neck Cancers

Microfluidic Mixing: A Physics-Oriented Review

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