A Cascade Targeted and Activatable NIR-II Nanoprobe for Highly Sensitive Detection of Acute Myeloid Leukemia in an Orthotopic Model

Semiconductor Nanocrystals Emitting in the Second Near‐Infrared Window: Optical Properties and Application in Biomedical Imaging

“…[188,189] Such NIR-II probes based on Ag 2 S SNCs were designed by Wang and co-workers for accurate diagnosis of traumatic brain injury, acute myeloid leukemia, and cancer. [94,190,191] Outside the target region, the fluorescence Adv. Optical Mater.…”

“…[ 188,189 ] Such NIR‐II probes based on Ag 2 S SNCs were designed by Wang and co‐workers for accurate diagnosis of traumatic brain injury, acute myeloid leukemia, and cancer. [ 94,190,191 ] Outside the target region, the fluorescence of the nanoprobe was in the “off” state owing to the fluorescence resonance energy transfer (FRET) from Ag 2 S SNCs to the attached A1094 chromophore. Once reaching the target region, the interaction between the probe and specific biomarkers in pathological tissues inhibited FRET, triggering the “on”‐ effect of the NIR‐II fluorescence.…”

“…[30,86] Thus, their emission can be readily tuned into the NIR-II region, and compared to other NIR-emitting Pb-/Hg-based SNCs, Ag-based binary SNCs exhibit much higher biocompatibility due to the absence of highly toxic elements. [49,94,95] The lack of toxicity of silver chalcogenides is also ensured by their extremely low solubility (K sp (Ag 2 S) = 6.3 × 10 −50 , K sp (Ag 2 Se) = 2.0 × 10 −64 , K sp (Ag 2 Te) = 2.0 × 10 −72 ), which greatly reduces potential damage caused by metal ions released into body and/or environment. [49] There have been considerable efforts devoted to synthesis of Ag 2 X SNCs with desired optical properties, as will be considered here.…”

Sensing and imaging of PPi in vivo using lanthanide-based second near-infrared luminescent probes

“…Compared to optical imaging in the visible (450-750 nm) and first near-infrared (NIR-I, 750-900 nm) regions, the second near-infrared (NIR-II, 1000-1700 nm) fluorescence imaging is beneficial due to the deeper tissue penetration and higher spatial resolution owing to the reduced photo-scattering and lower auto-fluorescence from living tissue. [25][26][27][28][29] To date, several types of NIR-II fluorescent probes have been reported for the diagnosis of diseases, [30][31][32] including small molecule dyes, 33,34 gold nanoclusters, 35 quantum dots, [36][37][38][39] etc. Among them, NIR-II luminescent lanthanide nanoparticles have shown great potential in biological applications due to their low toxicity and high optical stability.…”

Highly Efficient Near-Infrared II Electrochemiluminescence from NaYbF 4 Core Mesoporous Silica Shell Nanoparticles

“…The second near-infrared (NIR-II) window fluorescence emission between 950-1700 nm, with significant advantages of deeper penetration, higher spatiotemporal resolution and better signal-to-background ratio, has received considerable attention in bioimaging and disease diagnosis. [1][2][3][4] Meanwhile, this spectral domain is also very attractive for emerging electrochemiluminescence (ECL) biological applications such as cell plasma membrane imaging and electric-driven antibacterial, [5][6][7] because it can minimize the impact of photon scattering and auto-fluorescence. However, compared with the rapid development of NIR-II fluorescent materials in recent years, 8,9 NIR-II ECL luminophores are still difficult to obtain.…”