A Case Control Etiologic Study of Sarcoidosis

Abstract

Past research suggests that environmental factors may be associated with sarcoidosis risk. We conducted a case control study to test a priori hypotheses that environmental and occupational exposures are associated with sarcoidosis. Ten centers recruited 706 newly diagnosed patients with sarcoidosis and an equal number of age-, race-, and sex-matched control subjects. Interviewers administered questionnaires containing questions regarding occupational and nonoccupational exposures that we assessed in univariable and multivariable analyses. We observed positive associations between sarcoidosis and specific occupations (e.g., agricultural employment, odds ratio [OR] 1.46, confidence interval [CI] 1.13-1.89), exposures (e.g., insecticides at work, OR 1.52, CI 1.14-2.04, and work environments with mold/mildew exposures [environments with possible exposures to microbial bioaerosols], OR 1.61, CI 1.13-2.31). A history of ever smoking cigarettes was less frequent among cases than control subjects (OR 0.62, CI 0.50-0.77). In multivariable modeling, we observed elevated ORs for work in areas with musty odors (OR 1.62, CI 1.24-2.11) and with occupational exposure to insecticides (OR 1.61, CI 1.13-2.28), and a decreased OR related to ever smoking cigarettes (OR 0.65, CI 0.51-0.82). The study did not identify a single, predominant cause of sarcoidosis. We identified several exposures associated with sarcoidosis risk, including insecticides, agricultural employment, and microbial bioaerosols.

Sarcoidosis: the links between epidemiology and aetiology

“…A US based study has identified agricultural employment, insecticides, and microbial bio-aerosols (moulds and mildews) as being associated with sarcoidosis risk 30. Further analysis of the ACCESS study data reported positive associations with employment in the retail of building materials, hardware, garden supplies, and mobile homes.…”

“…Rather oddly, smoking at any time appears to be associated with a reduced risk 30 61. It has been suggested that foreign particulate matter, at a nanoparticle scale (<1 μm), may be the reason why agents cannot be visualised under microscopy 3.…”

Difficulties of differential diagnostics of primary hyperparathyroidism and sarcoidosis of cervical lymph nodes

“…По данным многоцен-трового исследования ACCESS (A Case Control Etiologic Study of Sarcoidosis, 1969Sarcoidosis, -1999, включавшего 736 пациентов, у 699 выявлено поражение легких и средостения, у 368 -других органов и только у 6 имелся изолированный саркоидоз шейных лимфо-узлов [11].…”

Comorbidity diseases in adults with diagnosed interstitial lung diseases among inhabitants of the Silesian voivodeship, Poland

“…Wśród czynników sprzyjających zachorowaniu wymienia się ekspozycję na pyły organiczne i nieorganiczne [6][7][8], zanieczyszczenia środowiska mykobakteriami [9], narażenie na czynniki chemiczne, gazy, pary, promieniowanie jonizujące, stosowanie leków lub substancji psychoaktywnych [10][11][12], ekspozycję na dym tytoniowy [13][14], wirusowe lub bakteryjne zakażenia płuc, występowanie refluksu żołądkowo-przełykowe-go [14] oraz wiek i predyspozycje genetyczne [7,[15][16][17]. Tylko jednak w co 3. przypadku chorób śródmiąższo-wych płuc możliwe jest ustalenie etiologii [18].…”