A case-control study on risk factors of breast cancer in China

Xu, Ya; Sun, Qiang; Shan, Guang; Zhang, Jin; Liao, Hai; Li, Shi Yong; Jiang, Jun; Shao, Zhi Min; Jiang, Hong; Shen, N; Shi, Yue; Yu, Chengbin; Zhang, Bao Ning; Chen, Yan Hua; Duan, Xuening; Li, Bo

doi:10.5114/aoms.2012.28558

Cited by 37 publications

(36 citation statements)

References 51 publications

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“…For example, obesity during pre-teen years (ages 5-10) is inversely related to breast cancer risk (Baer et al, 2010). On the other hand, obesity after menopause is positively related to breast cancer incidence (Bates and Carmichael, 2004;Lahmann et al, 2004;Cheraghi et al, 2012;Phipps et al, 2012;Xu et al, 2012). Although this is fairly well established, the relationship between premenopausal obesity and breast cancer risk remains less clear.…”

Section: Obesitymentioning

confidence: 91%

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Alegre¹,

Knowles²,

Robison³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cancer prevention is rapidly emerging as a major strategy to reduce cancer mortality. In the field of breast cancer, significant strides have recently been made in the understanding of underlying preventive mechanisms. Currently, three major strategies have been linked to an increase in breast cancer risk: obesity, lack of physical exercise, and high levels of saturated dietary fat. As a result, prevention strategies for breast cancer are usually centered on these lifestyle factors. Unfortunately, there remains controversy regarding epidemiological studies that seek to determine the benefit of these lifestyle changes. We have identified crucial mechanisms that may help clarify these conflicting studies. For example, recent reports with olive oil have demonstrated that it may influence crucial transcription factors and reduce breast tumor aggressiveness by targeting HER2. Similarly, physical exercise reduces sex hormone levels, which may help protect against breast cancer. Obesity promotes tumor cell growth and cell survival through upregulation of leptin and insulin-like growth factors. This review seeks to discuss these underlying mechanisms, and more behind the three major prevention strategies, as a means of understanding how breast cancer can be prevented.

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Section: Obesitymentioning

confidence: 91%

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Alegre¹,

Knowles²,

Robison³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…After reviewing the full text of these studies in detail, a total of 39 articles, involving 100,452 participants from 14 provinces, municipalities and regions, were included in the final review (Appendix 1). Among these included studies, we identified 6 cohort studies (Li et al, 2005;Shannon et al, 2005;Wang et al, 2006;Dai et al, 2010;Pronk et al, 2011;Shrubsole et al, 2011;) and 33 case-control studies (Lu et al, 1992;Xu et al, 1997;Zhao et al, 1999;Tao et al, 2002;Zou et al, 2002;Zhang et al, 2003;Chow et al, 2005;Lee et al, 2005;Chou et al, 2006;Huang et al, 2006;Li et al, 2006;Jin, 2007;Ma, 2007;Zhang et al, 2007;Kallianpur et al, 2008;Ren, 2008;Wang et al, 2008;Shrubsole et al, 2009;Wang et al, 2009;Zhang et al, 2009;Qian et al, 2010;Shi et al, 2010;Bao et al, 2011;Dai et al, 2011;Leu et al, 2011;Zhang et al, 2011;Hou et al, 2012;Xu et al, 2012;Yu et al, 2012;Wang et al, 2013). According to the NOS items, 11 studies were evaluated as high quality, 25 studies as modest quality, and 3 studies as low quality, respectively.…”

Section: Description Of Studiesmentioning

confidence: 99%

Tea Consumption, Alcohol Drinking and Physical Activity Associations with Breast Cancer Risk among Chinese Females: a Systematic Review and Meta-analysis

Gao¹,

Yu²,

Liu³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…During last decades major advances have been made in screening for risk factors associated with breast cancer in high-prevalence areas [2]. Knowledge regarding clinical symptoms of breast cancer and the possibilities of screening tests among healthy population is higher comparing to the other malignancies and wide acceptance among women for breast cancer screening results in increased detection rate of early breast cancer [3].…”

mentioning

confidence: 99%

Expression of IAP family proteins and its clinical importance in breast cancer patients

Pluta¹,

Jeziorski²,

Cebula-Obrzut³

et al. 2015

neo

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Inhibitor of apoptosis (IAP) family proteins is involved in mechanisms of resistance to apoptosis in various cancer cells. The aim of this study was to assess the expression of selected IAP proteins such as XIAP, cIAP-1, cIAP-2 and survivin in breast cancer patients and evaluates their relationship with the prognostic and predictive factors and their impact to overall survival (OS) and progression free survival (PFS). The study was conducted with the use of tissue samples prospectively collected from 92 previously untreated female breast cancer patients. The control encompassed 10 fibroadenoma patients. The expression of XIAP, cIAP-1, cIAP-2 and survivin was assessed using flow multicolor cytometry. XIAP expression was present in 99 % of the breast cancer patients (91/92) with the median expression 13.65% (range 1-66.8%). Expression of XIAP in breast cancer was significantly higher compared to the control group (p=0.006). Median expression of cIAP-1, cIAP-2 and survivin in the study group was 25.95% (range 0.8-83.7%), 16.7% (range 1-53.2%) and 4.6% (range 0-43%) respectively. In the rank Spearman test, strong correlations (p<0.001) were seen among the expressions of XIAP, cIAP-2 and survivin, in all combination. Additionally, week correlation between XIAP and cIAP-1 was observed (p=0.02). The median expression of XIAP and survivin was significantly higher in more advanced tumors (stages pT2/pT3 vs. pT1). The median PFS and OS in breast cancer group were 46.15 and 47.1 months respectively. No significant correlations were observed among expressions of IAP family proteins and survival. However, low expression of XIAP in breast cancer showed trend to longer PFS (p=0.08). XIAP, cIAP-1 cIAP-2 and survivin participate in antiapoptotic mechanisms in breast cancer and XIAP and survivin seem to have the most significant prognostic importance. Further studies are needed to establish more complete prognostic and predictive values of IAP family proteins in breast cancer patients.

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A case-control study on risk factors of breast cancer in China

Cited by 37 publications

References 51 publications

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Mechanics behind Breast Cancer Prevention - Focus on Obesity, Exercise and Dietary Fat

Tea Consumption, Alcohol Drinking and Physical Activity Associations with Breast Cancer Risk among Chinese Females: a Systematic Review and Meta-analysis

Expression of IAP family proteins and its clinical importance in breast cancer patients

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