One recent trend in optical remote sensing is to increase observation frequencies. However, there are still challenges on the night side when sunlight is not available. Due to their powerful capabilities in low-light sensing, nightlight satellite sensors have been deployed to capture nightscapes of Earth from space, observing anthropomorphic and natural activities at night. To date, the mainstream of nightlight remote sensing applications has mainly focused on artificial lights, especially within cities or self-luminous bodies, such as fisheries, oil, offshore rigs, etc. Observations taken under moonlight are often discarded or corrected to reduce lunar effects. Some researchers have discussed the possibility of using moonlight as a useful illuminating source at night for the detection of nocturnal features on Earth, but no quantitative analysis has been reported so far. This study aims to systematically evaluate the potential of moonlight remote sensing with mono-spectral Visible Infrared Imaging Radiometer Suite/Day-Night-Band (VIIRS/DNB) imagery and multi-spectral photos taken by astronauts from the International Space Station (ISS), as well as unmanned aerial vehicle (UAV) night-time imagery. Using the VIIRS/DNB, ISS and UAV moonlight images, the possibilities of the moonlight remote sensing were first discussed. Then, the VIIRS/DNB, ISS, UAV images were classified over different non-self-lighting land surfaces to explore the potential of moonlight remote sensing. The overall accuracies (OA) and kappa coefficients are 79.80% and 0.45, 87.16% and 0.77, 91.49% and 0.85, respectively, indicating a capability to characterize land surface that is very similar to daytime remote sensing. Finally, the characteristics of current moonlight remote sensing are discussed in terms of bands, spatial resolutions, and sensors. The results confirm that moonlight remote sensing has huge potential for Earth observation, which will be of great importance to significantly increase the temporal coverage of optical remote sensing during the whole diurnal cycle. Based on these discussions, we further examined requirements for next-generation nightlight remote sensing satellite sensors.