A case of acquired reactive perforating collagenosis

Almond, Lorna; Matthewman, Naomi; Stringer, Howard; Francis, Nicholas; Abadie, Mohammed Al

doi:10.1111/ajd.12618

Cited by 9 publications

(9 citation statements)

References 5 publications

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“…Some therapeutics was reported to be effective, including emollients, anti-histamines, keratolytics, doxycycline, retinoids, steroids, allopurinol, ultraviolet B phototherapy, and transcutaneous electrical nerve stimulation. [ 3 , 5 ]…”

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confidence: 99%

Acquired reactive perforating collagenosis

Wang

Liu

Wang

et al. 2020

Chinese Medical Journal

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confidence: 99%

Acquired reactive perforating collagenosis

Wang

Liu

Wang

et al. 2020

Chinese Medical Journal

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“…The treatment of ARPC involves controlling the underlying disease and relieving itching. However, the treatment consensus for ARPC is not clear, and reported therapies are diverse [ 2 ]. Herein, we present a rare case of ARPC without systemic disease, which was effectively treated with itraconazole.…”

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confidence: 99%

Successful treatment of acquired reactive perforating collagenosis with itraconazole

Cao

Liu

2021

Eur J Med Res

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Background Acquired reactive perforating collagenosis (ARPC) is a rare form of transepithelial elimination in which altered collagen is extruded through the epidermis. Case presentation A 23-year-old male presented with cup-like ulcerated lesions on his limbs since 3 months. A series of serological and immunological tests showed no abnormalities. A diagnosis of ARPC was based on skin biopsy findings. The patient was cured using treatment with itraconazole for 8 weeks, in the absence of a fungal infection. Conclusions The anti-inflammatory and anti-angiogenic effects of itraconazole can have good therapeutic benefits for ARPC.

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“…Histopathologically thickening and clefting of dermal collagen bundles and proliferation of fusiform cells are found 1 . Reactive perforating collagenosis is mainly an epidermal disorder, presenting as keratotic papules with a central adherent plug, typically located on the trunk and extensor surfaces of limbs 3 . Histopathologically, transepidermal elimination of collagen bundles is characteristic 3 …”

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confidence: 99%

“…Gadolinium is thought to deposit in tissues leading to fibrosis 1 . Reactive perforating collagenosis is a primary perforating disorder, classically related to chronic renal failure 3 . Pruritus and scratching can act as trigger 3 .…”

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confidence: 99%