A case of acute necrotising pancreatitis following the second dose of Pfizer-BioNTech COVID-19 mRNA vaccine

Walter, Talia; Connor, Saxon; Stedman, Catherine; Doogue, Matthew

doi:10.22541/au.162458630.05700882/v1

Cited by 2 publications

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“…Parkash et al reported a case of AP in a 96-year-old female a few days after she received the vaccine [ 12 ]. Walter et al reported a case of acute necrotizing pancreatitis 10 h after the administration of the second dose of Pfizer-BioNTech COVID-19 mRNA vaccine in a 43-year-old male [ 13 ]. Cieslewicz reported a case of AP injury 20 h after Pfizer-BioNTech COVID-19 mRNA vaccination in a 29-year-old female [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent

et al. 2021

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A 17-year-old male was referred to the emergency room with sharp abdominal pain, pallor, sweating, and vomiting 12 h after the administration of his first Pfizer-BioNTech vaccine for coronavirus disease 2019 (COVID-19). He had abdominal pain, an increase in serum lipase value of > 3 times the upper limits of normal, and magnetic resonance imaging (MRI) findings consistent with acute mild pancreatitis (AP). He was started on treatment with fluid therapy and non-steroidal anti-inflammatory drugs for pain management, after which he recovered rapidly and was discharged on the fourth day after hospitalization. The available data are difficult to interpret as AP is a relatively frequent disease, but its occurrence after vaccination seems extremely rare. Although it is a rare event, AP should be considered after COVID-19 vaccination, especially in those exhibiting abdominal tenderness and vomiting, which should be promptly treated and adequately investigated.

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Section: Discussionmentioning

confidence: 99%

Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent

et al. 2021

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Living with COVID-19: The road ahead

Wei

Tan

Cook

et al. 2021

Ann Acad Med Singap

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Introduction: The COVID-19 pandemic has affected the world for more than a year, with multiple waves of infections resulting in morbidity, mortality and disruption to the economy and society. Response measures employed to control it have generally been effective but are unlikely to be sustainable over the long term. Methods: We examined the evidence for a vaccine-driven COVID-19 exit strategy including academic papers, governmental reports and epidemiological data, and discuss the shift from the current pandemic footing to an endemic approach similar to influenza and other re spiratory infectious diseases. Results: A desired endemic state is characterised by a baseline prevalence of infections with a generally mild disease profile that can be sustainably managed by the healthcare system, together with the resumption of near normalcy in human activities. Such an endemic state is attainable for COVID-19 given the promising data around vaccine efficacy, although uncertainty remains around vaccine immunity escape in emergent variants of concern. Maintenance of non-pharmaceutical interventions remains crucial until high vaccination coverage is attained to avoid runaway outbreaks. It may also be worthwhile to de-escalate measures in phases, before standing down most measures for an endemic state. If a variant that substantially evades immunity emerges, it will need to be managed akin to a new disease threat, with pandemic preparedness and response plans. Conclusion: An endemic state for COVID-19, characterised by sustainable disease control measures, is likely attainable through vaccination. Keywords: COVID-19, endemic, non-pharmaceutical interventions, transition, vaccination

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A case of acute necrotising pancreatitis following the second dose of Pfizer-BioNTech COVID-19 mRNA vaccine

Cited by 2 publications

References 0 publications

Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent

Acute Mild Pancreatitis Following COVID-19 mRNA Vaccine in an Adolescent

Living with COVID-19: The road ahead

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