A case of acute pancreatitis with occupational exposure to organophosphorus compound

Goud, Manjunatha; Deepa, K.; Devi, Oinam Sarsina; Devaki, RN; Anitha, Mallappa

doi:10.4103/0971-6580.97226

Cited by 8 publications

(5 citation statements)

References 6 publications

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“…In our cohort, there were pancreas, gallbladder, and liver disease cases among people with gastrointestinal problems. Studies have shown that people with pesticide poisoning may have subclinical signs of acute pancreatitis [ 39 , 40 ].…”

Section: Discussionmentioning

confidence: 99%

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Altynova,

Khamdiyeva,

Garshin

et al. 2023

Toxics

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The association of genetic polymorphisms with the individual sensitivity of humans to the action of pesticide pollution is being actively studied in the world. The aim of this study was a molecular epidemiological analysis of candidate polymorphisms of genes involved in pesticide metabolism, detoxification, and antioxidant protection. Some of the selected polymorphisms also relate to susceptibility to cancer and cardiovascular, respiratory, and immune system diseases in individuals exposed to pesticides for a long time. For a case-control study of a unique cohort of people exposed to organochlorine pesticides for 10 years or more were chosen, a control cohort was selected that matched with the experimental group by the main population characteristics. PCR-PRLF and genome-wide microarray genotyping (GWAS) methods were used. We identified 17 polymorphisms of xenobiotic detoxification genes and 27 polymorphisms of antioxidant defense genes, which had a significantly high statistical association with the negative impact of chronic pesticide intoxication on human health. We also found 17 polymorphisms of xenobiotic detoxification genes and 12 polymorphisms of antioxidant defense genes that have a protective effect. Data obtained added to the list of potential polymorphisms that define a group at high risk or resistant to the negative effects of pesticides.

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Section: Discussionmentioning

confidence: 99%

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Altynova,

Khamdiyeva,

Garshin

et al. 2023

Toxics

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“…Peradeniya OP poisoning scale 23 was used to assess severity or organophosphorus (OP) intoxication. Five common clinical manifestations of OP poisoning have been selected as parameters, each to be assessed on a 3-point scale varying from 0-2.…”

Section: Methodsmentioning

confidence: 99%

“…Studies have also shown that serum amylase above the normal range on the day of admission was related to the development of respiratory failure and the elevation of amylase level and predictive of subsequent respiratory failure [19][20] . Moreover, the elevated level of enzyme (hyperamylasaemia) is closely related to clinical severity and the presence of shock [21][22][23] .…”

Section: Introductionmentioning

confidence: 99%

Serum Amylase Level in Acute Organophosphorus Compound Poisoning in a Tertiary Level Hospital

et al. 2021

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Background: Organophosphorus compound (OPC) poisoning is an important clinical problem in the developing world and kills an estimated 3,00,000 people every year. In spite of high case fatality rate early and proper management is crucial to save the lives and alleviate the sufferings. Amylase level is an important biochemical marker, which is closely related to severity of acute OPC poisoning. Therefore, to assess Serum amylase level in acute organophosphorus compound poisoning in a tertiary level hospital was the objective of the study. Methods: This research was a hospital based descriptive cross-sectional study and was conducted at the inpatient department of Medicine in Dhaka Medical College. 50 Patient admitted in medicine department due to OPC poisoning and evidenced by history taking and physical examination were included in the study. Ethical issues were ensured properly. After written informed consent history and physical examination were done. Rest of the data were collected by interviewing each patient or from attendant of the patient by using a semi-structured questionnaire. Scoring of the severity were done by researcher himself by Peradeniya Organophosphorus Poisoning (POP) scale (Score range 0 to 11). Values of amylase level were collected from patient record file. All the Data was analysed by computer with the help of SPSS 16. Results: Out of a total of 50 patients, 24 (48%) were males and 26 (52%) were females. OPC poisoning was most frequent (52%) in age group 21-30 years. Mean age was 23.96 ± 6.071 SD. 96% (48) study population were Muslim and rest 4 % (2) were Hindus with diverse occupation. 86% population came from rural area whereas only 14% population reside in urban area. Among them suicidal attempts were seen significantly which was 96% and rest of them were accidental ingestion. Amylase level estimation were done in each case and 32 % (16) patient had elevated amylase level (>100U/L) and 68% (34) patient had amylase level within normal limit. Mean amylase concentration was 62.2U/L (SD±18.77) and among the 16 patients who had elevated serum amylase level mean concentration was 376.56U/L (SD±266.124). Mean amylase level differed significantly between these two groups (p value < 0.0001) estimated by one way ANOVA. Spearman Correlation and One way ANOVA both showed significant association between severity (assessed by POP scale) and elevated level of serum amylase (p value <0.0001). Outcome analysis showed that 47 patients recovered and 3 patients died. Their mean hospital stay was 3.87 (±1.76) days and relationship between serum amylase level and duration of hospital stay and was found to be significant in chi-square analysis (p value- <0.0001). Conclusion: Hyperamylasaemia in OPC poisoning can be used an important biomarker to assess the severity of the patient which may guide the clinicians for further management. J MEDICINE 2021; 22: 119-126

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“…Incidence of organophosphorus poisoning is soaring due to easy availability in rural settings of developing countries where its use as pesticide is quite high [1] . Worldwide 3 million people are exposed each year with 300000 deaths attributed to them [2,3] .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Acute Pancreatitis and Hyperamylasemia in Acute Organophosphorus poisoning in Kashmir valley (North India)

Wani Abdul Ahad,

Naik Muzaffar,

Jawhar ul Islam

et al. 2022

Indian Journal of Forensic Medicine & Toxicology

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Organophosphorus poisoning is soaring due to easy availability in rural settings of developing countries. There are many reports of Acute Pancreatitis associated with OP poisoningand a casual relationship has been demonstrated in animal models. This study was therefore designed to determine the prevalence of hyperamylasemia and acute pancreatitis in organophospate poisoning in our setup and to reduce mortality and hospital stay by its early detection. This is a cross sectional hospital based study carried out in SKIMS Medical College, Srinagar, J&K which is tertiary care facility. All patients included were above 18 years of age with a recent history of organophosphate ingestion, cutaneous absorption or inhalation with clinical signs and symptoms of organophosphate poisoning. Confounding factors like drugs causing pancreatitis, ERCP within 24 hrs, previous history of pancreatitis, cholelithiasis and or any other local pathology were excluded. Serum Amylase and Lipase were measured. Imaging like ultrasonography and CT scan Abdomen was ordered. BISAP scoring was used to assess severity of acute pancreatitis. 50 patients with ingestion of organophosphates were evaluated. 23 patients developed abdominal pain, among which 11 patients had hyperamylasemia while 7 developed Clinical acute pancreatitis with high lipase and imaging findings. 2/3 of patients who developed pancreatitis had mild severity while other 1/3 had severe severity. Pancreatitis in Organophosphorus is not uncommon and needs high clinical suspicion for early diagnosis and management.

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A case of acute pancreatitis with occupational exposure to organophosphorus compound

Cited by 8 publications

References 6 publications

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Case-Control Study of the Association between Single Nucleotide Polymorphisms of Genes Involved in Xenobiotic Detoxification and Antioxidant Protection with the Long-Term Influence of Organochlorine Pesticides on the Population of the Almaty Region

Serum Amylase Level in Acute Organophosphorus Compound Poisoning in a Tertiary Level Hospital

Prevalence of Acute Pancreatitis and Hyperamylasemia in Acute Organophosphorus poisoning in Kashmir valley (North India)

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