A Case of AFP Producing Gastric Cancer which responded to Pre-Operative Chemotherapy

We report the case of a patient with advanced gastric cancer producing alpha fetoprotein (AFP), who was treated successfully by adjuvant chemotherapy with S-1 for 36 months. The patient, a 75-year-old man, was admitted for anemia, and was diagnosed as having gastric cancer by endoscopy. Distal gastrectomy was performed in May 2008. Histopathological examination plus immunohistochemistry confirmed that the tumor produced AFP; the tumor stage was determined as T2 N0 P0 CY0, Stage Ⅱ A. The serum AFP level was elevated to 23.4ng/ml. Since the prognosis of AFP-producing gastric carcinoma is poor, the patient was treated with S-1 for three years, guided by the serum AFP level. By the end of three years of chemotherapy, the serum AFP level had returned to the normal range. At present, more than 5 years since the surgery, the patient remains well, without evidence of recurrence (as determined by the serum AFP level and abdominal CT).

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A Case of AFP Producing Gastric Cancer which responded to Pre-Operative Chemotherapy

Cited by 3 publications

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A Case of Early Gastric Cancer Producing Alpha-Fetoprotein with Local Recurrence at a Relatively Early Stage after Laparoscopy-Assisted Distal Gastrectomy

A Case of Early Gastric Cancer Producing Alpha-Fetoprotein with Local Recurrence at a Relatively Early Stage after Laparoscopy-Assisted Distal Gastrectomy

A Case of Alpha-fetoprotein Producing Gastric Cancer Recurred after Chemoradiotherapy and Treated by Laparoscopic-assisted Total Gastrectomy

Long-term Survival of a Patient with α−Fetoprotein-Producing Advanced Gastric Cancer after Adjuvant Chemotherapy with S–1

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