A case of aggressive bullous pemphigoid associated with the defective functional variant of Fc gamma receptor IIb: Implications for pathogenesis?

Guilabert, Antonio; Lozano, Francisco; Iranzo, Pilar; Suárez-Casasús, Belén; Pablo, I Martínez‐De; Julià, Marc; Mascaró, José M.

doi:10.1016/j.jaad.2009.02.017

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…In this work we examined if certain polymorphisms of two FcR genes, CD16A and CD32A, underlie the attachment of specific autoantibody types and abnormal blistering skin phenotypes in pemphigus and SABDs [19,20]. It was postulated that these polymorphisms affect receptor signaling and may be associated with ABDs susceptibility.…”

Section: Discussionmentioning

confidence: 99%

A Comparative Analysis of CD32A and CD16A Polymorphisms in Relation to Autoimmune Responses in Pemphigus Diseases and Subepithelial Autoimmune Blistering Disorders

Gornowicz‐Porowska

Kowalczyk

Seraszek‐Jaros

et al. 2020

Genes

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Autoimmune blistering dermatoses (ABDs) are characterized by autoantibodies to keratinocyte surface antigens and molecules within the dermal–epidermal junction causing disruption of skin integrity. The affinity of Fc receptors (FcRs) causing an autoimmune response in ABDs may vary based on single-nucleotide polymorphisms (SNPs) in FcRs determining the course of disease. This study aimed to explore the effects of CD16A and CD32A SNPs on the autoimmune response in several ABDs. In total, 61 ABDs patients were investigated. ELISA tests, direct immunofluorescence (DIF), TaqMan SNP Genotyping Assays, and statistical analyses were performed. The CA genotype (composed of allele C and A) of rs396991 in CD16A had a higher affinity for tissue-bound IgG1 in pemphigus and for C3 in subepithelial ABDs, showing statistical significance. The greatest relative risk (odds ratio) was reported for AA (rs396991 of CD16A) and CC (rs1801274 of CD32A) homozygotes. There were no statistically significant differences between certain genotypes and specific circulating autoantibodies (anti-DSG1, anti-DSG3 IgG in pemphigus; anti-BP180, anti-BP230 IgG) in subepithelial ABDs. Our findings indicated that rs396991 in CD16A may be of greater importance in ABDs development. Moreover, FcR polymorphisms appeared to have a greater impact on tissue-bound antibodies detected using DIF than circulating serum antibodies in ABDs.

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Section: Discussionmentioning

confidence: 99%

A Comparative Analysis of CD32A and CD16A Polymorphisms in Relation to Autoimmune Responses in Pemphigus Diseases and Subepithelial Autoimmune Blistering Disorders

Gornowicz‐Porowska

Kowalczyk

Seraszek‐Jaros

et al. 2020

Genes

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“…Thus, FcRs function may be a key purpose in the treatment with monoclonal antibodies (mAbs) therapy. Probably, FcRs may be a molecular link between ABD and malignancies [99,100]. FcRs-targeting therapies are used for ABD and cancer, e.g.…”

Section: Development Of Paraneoplastic Immunitymentioning

confidence: 99%