A case of ampullary gangliocytic paraganglioma

Abstract

Gangliocytic paragangliomas (GPs) are rare tumors of the duodenum, presenting as single sessile or pedunculated polypoid masses. Clinical manifestations of duodenal GPs can vary from an incidental finding at endoscopy to frequent upper gastrointestinal bleeding caused by mucosal ulceration and abdominal pain. GPs are considered benign, but the disease can recur and spread to regional lymph nodes. A 41-year-old female presented with abdominal pain. Upper gastrointestinal endoscopy revealed a subepithelial tumor of the ampulla of Vater in the second portion of the duodenum. The tumor was resected using the endoscopic mucosal resection technique. The tumor was diagnosed as benign GP of the duodenum using histological and immunohistochemical staining procedures.

Endoscopic resection of a periampullary gangliocytic paraganglioma of the duodenum: A case report

“…In a follow up period from 12 to 96 months no death from GP was observed. Furthermore neither Rafiullah nor Yang observed any relapses of duodenal GPs in their case reports during a long term follow up of 3 years [9], [10]. Moreover Okubo et al performed a multi-institutional retrospective study in japan [7].…”

Duodenal gangliocytic paraganglioma, successfully treated by local surgical excision-a case report

“…Complete excision of the mass by surgical or endoscopic means is the only cure. Endoscopic removal is the first option in GPs and is both safe and adequate [7] , [8] , [9] . In the case of a periampullary or a large lesion, however, endoscopic resection may be challenging or impossible and therefore surgical resection of the lesion remains as the only therapeutic option.…”

Ampullary gangliocytic paraganglioma with lymph node metastasis

“…Gangliocytic paraganglioma (GP) is a rare tumor that typically develops in the duodenum; it is composed of 3 types of cells: epithelioid endocrine, spindle-like, and ganglion-like cells. [ 1 ] It manifests as symptoms including abdominal pain, gastrointestinal bleeding, and weight loss. Nevertheless, occasionally, GP is detected on endoscopic or radiologic examination incidentally.…”