Duodenal gangliocytic paraganglioma, successfully treated by local surgical excision-a case report

Papaconstantinou, Dimitris; Machairas, Nikolaos; Damaskou, Vasileia; Zavras, Nick; Kontopoulou, Christine; Machairas, Anastasios

doi:10.1016/j.ijscr.2017.01.046

Cited by 11 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Considering the traumatic and risky nature of surgery near the jugular abdominal region, and the fact that many studies have supported that the risk of LNM and distant metastasis of DGP is relatively low, coupled with the development of endoscopic diagnostic and therapeutic technology, more and more scholars are employing endoscopic techniques (e.g., EMR/endoscopic submucosal dissection [ESD]/EP) to manage DGP after adequate preoperative evaluation to rule out metastatic signs and have achieved good results. Palomino-Martinez et al [ 11 ] and Ebi et al [ 12 ] successfully resected DGP near the nipple using EMR; Manglekar et al [ 13 ] successfully resected DGP near the nipple using ESD; Sanchez-Pobre et al [ 14 ] successfully managed DGP near the nipple after gastrectomy using endoscopic resection + EST; Arif et al [ 15 ] and Papaconstantinou et al [ 16 ] used duodenotomy to locally resect DGP near the nipple, and all of the above reports achieved satisfactory results, but some of them had postoperative complications such as cholangitis or pancreatitis. In the present case, postoperative complications were effectively prevented while the papillary DGP was managed by EP combined with endoscopic retrograde cholangiopancreatography technique.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic papillectomy combined with endoscopic retrograde cholangio-pancreatography for duodenal gangliocytic paraganglioma: A case report

Cai,

Hu,

Fang

2023

Medicine

View full text Add to dashboard Cite

Rationale: Gangliocytic paraganglioma is a rare tumor that can occur in several organs throughout the body. Gangliocytic paraganglioma of the main duodenal papilla is even rarer. This study analyzes and discusses the endoscopic management of a case of gangliocytic paraganglioma of the main duodenal papilla and reviews the relevant literature. It is hoped that this study will increase clinicians’ awareness of this disease. Patient concerns: Electron endoscopy reveals a duodenal main papillary tumor, and the patient desires further clarification of the nature of the tumor and the next step in the treatment plan. Diagnoses: Duodenal gangliocytic paraganglioma. Interventions: As the patient lesion was located in the main duodenal papilla, we successfully performed endoscopic minimally invasive treatment of the tumor by endoscopic papillectomy combined with endoscopic retrograde cholangiopancreatography. Outcomes: The patient was discharged after the postoperative removal of the nasobiliary drain and returned to the hospital 2 months later to have the biliary stent removed; the patient was in good general condition at follow-up. Lessons: For duodenal main papillary tumor, we need to be alert to the possibility of gangliocytic paraganglioma. Since the tumor is located in the submucosa of the juxta-abdominal region, the preoperative biopsy positivity rate is low, and the tumor is often adjacent to or involves the biliopancreatic duct, endoscopic resection combined with endoscopic retrograde cholangiopancreatography can be considered for diagnosis and treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Endoscopic papillectomy combined with endoscopic retrograde cholangio-pancreatography for duodenal gangliocytic paraganglioma: A case report

Cai,

Hu,

Fang

2023

Medicine

View full text Add to dashboard Cite

show abstract

“…Duodenal gangliocytic paraganglioma (DGP) is one of the differential diagnoses of duodenal GIST. DGP is a rare nonchromaffin neuroendocrine neoplasm which lacks the ability to secrete catecholamine [6][7][8]. Both of DGPs and GISTs are located in the submucosal layer, so endoscopic biopsy is usually not exclusive.…”

Section: Discussionmentioning

confidence: 99%

“…Both of DGPs and GISTs are located in the submucosal layer, so endoscopic biopsy is usually not exclusive. Abdominal imaging study is unlikely to determine the accurate diagnosis [7]. Precise diagnosis is improbable without the immunohistochemical analysis [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

A rare serious case of retroperitoneal paraganglioma misdiagnosed as duodenal gastrointestinal stromal tumor: a case report

Mahmoud¹,

Salami²,

Salman³

2020

BMC Surg

View full text Add to dashboard Cite

Background: Pheochromocytoma (PCC) and Paraganglioma (PGL) are rare neuroendocrine neoplasms. These tumors harbour disastrous consequences during surgery due to catecholamine hypersecretion if they are undiagnosed or prepared inadequately preoperatively. Case presentation: A 41-year-old lady presented with mild left flank discomfort. She had experienced recurrent anxiety attacks accompanied by palpitations and headache which were managed previously as panic attacks. Radiologic investigations showed a retroperitoneal mass that located anteromedial to the left kidney, separated from the left adrenal gland and adherent to the 4th duodenal segment. During admission, her vital signs showed slight elevation of blood pressure (140\90-160\110) mmHg, thus 24-h urine metanephrine and normetanephrine were requested and the results revealed normal values. Upper gastrointestinal endoscopy failed to pass beyond the 3th duodenal segment and showed no pathologic evidence. According to her findings, a diagnosis of duodenal gastrointestinal stromal tumor (GIST) was suspected. During laparotomy, crises of hypertension and tachycardia followed by severe hypotension made the resection of the misdiagnosed mass very tricky. Immunohistochemical staining studies confirmed the diagnosis of paraganglioma. Conclusion: Paraganglioma is a life threatening disease and should always be considered as a differential diagnosis of asymptomatic retroperitoneal mass. The aim of our study is to present a challenging case of an undiagnosed retroperitoneal paraganglioma and to alarm our colleagues from such troubles. Publisher's NoteSpringer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

show abstract

“…To date, pancreaticoduodenectomy is the generally preferred treatment for GP. However, since GP grows slower than NET G1, less invasive procedures (especially endoscopic procedures) have gradually increased in popularity[12]. In fact, in our systematic review, 27 patients underwent endoscopic procedures and showed favorable outcomes, with the exception of one patient who required additional surgery because of a positive surgical margin.…”

Section: Introductionmentioning

confidence: 96%

Gangliocytic paraganglioma: An overview and future perspective

Okubo¹

2019

WJCO

View full text Add to dashboard Cite

Gangliocytic paraganglioma (GP) is rare neuroendocrine tumor (NET) with a good prognosis that commonly arising from duodenum. Although the tumor is characterized by its unique triphasic cells (epithelioid, spindle, and ganglion-like cells), the proportions of these three tumor cells vary widely from case to case, and occasionally, morphological and immunohistochemical similarities are found between GP and NET G1 (carcinoid tumors). Further, GP accounts for a substantial number of duodenal NETs. Therefore, GP continues to be misdiagnosed, most often as NET G1. However, GP has a better prognosis than NET G1, and it is important to differentiate GP from NET G1. In this article, I wish to provide up-to-date clinicopathological information to help oncologists gain better insight into the diagnosis and clinical management of this tumor.

show abstract

Duodenal gangliocytic paraganglioma, successfully treated by local surgical excision-a case report

Abstract: HighlightsDuodenal gangliocytic paraganglioma is a rare tumor usually with benign behavior.Resection of the tumor, either endoscopically or surgically is the treatment of choice.Complete removal of the mass offers cure and long-term survival.

Cited by 11 publications

References 12 publications

Endoscopic papillectomy combined with endoscopic retrograde cholangio-pancreatography for duodenal gangliocytic paraganglioma: A case report

Endoscopic papillectomy combined with endoscopic retrograde cholangio-pancreatography for duodenal gangliocytic paraganglioma: A case report

A rare serious case of retroperitoneal paraganglioma misdiagnosed as duodenal gastrointestinal stromal tumor: a case report

Gangliocytic paraganglioma: An overview and future perspective

Contact Info

Product

Resources

About