A case of an anaplastic meningioma metastasizing to the mediastinal lymph nodes

Nishida, Norihiro; Kanchiku, Tsukasa; Imajo, Yasuaki; Suzuki, Hitomi; Yoshida, Yuichiro; Kato, Yoshihiro; Hoshii, Yoshinobu; Taguchi, Toshihiko

doi:10.1179/2045772315y.0000000005

Cited by 6 publications

(9 citation statements)

References 44 publications

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“…Metastasis to the mediastinal lymph nodes is usually found concurrently with pulmonary metastasis. Mediastinal lymph node metastasis from a meningioma without pulmonary metastasis is very rare; we found only two cases while searching Medline 4,5 . One case involved a mediastinal metastasis from an intracranial meningioma, similar to the case presented here, while the second case involved metastasis from an intramedullary spinal meningioma of the thoracic vertebra.…”

Section: Discussionsupporting

confidence: 71%

Delayed solitary mediastinal lymph node metastasis from a benign meningothelial meningioma six years after surgical resection of an intracranial tumor

Jung

Park

2021

Thoracic Cancer

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Meningiomas are common intracranial neoplasms with benign features, and extracranial metastases are very rare. There have been no previous reports of solitary mediastinal lymph node metastasis from benign meningiomas without pulmonary lesions. Here, we present a case of an 82‐year‐old female who visited our department for mediastinal lymphadenopathy with a history of meningioma treated with total surgical resection six years prior. Endobronchial ultrasound‐guided transbronchial needle aspiration of the left lower paratracheal lymph node revealed a benign meningothelial meningioma. In patients with a history of meningioma, extracranial metastasis should be considered in the differential diagnosis of mediastinal lymphadenopathy.

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Section: Discussionsupporting

confidence: 71%

Delayed solitary mediastinal lymph node metastasis from a benign meningothelial meningioma six years after surgical resection of an intracranial tumor

Jung

Park

2021

Thoracic Cancer

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“…A systematic review concluded the average age of spinal meningiomas was 62.6 years old after adjusting the sample size of various studies ( 20 ). The median age of our patients was 25 (range, 13–46) years, while the median age of literature cases was 55 (range, 47–68) years ( 8 , 9 , 12 , 13 ). Both samples were small and apparently heterogenous, thereby offering no consistent information concerning susceptible age.…”

Section: Discussionmentioning

confidence: 86%

“…The radiological features of PSAM were rarely mentioned in literature. Ito et al and Nishida et al respectively reported a case with homogeneous enhancement and swelling spinal cord ( 8 , 9 ). PSAMs in our study demonstrated a relatively consistent presentation.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review

Wu¹,

Wang²,

Zou³

et al. 2023

Transl Cancer Res

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Background Primary spinal anaplastic meningioma (PSAM) is a very rare entity in the spinal canal. Therefore, the clinical features, treatment strategy, and long-term outcomes remain poorly studied. Case Description Clinical data of six patients with PSAM treated at one single institution were retrospectively analyzed and all previously reported cases in the English literature were reviewed. There were three male and three female patients with a median age of 25 years. The duration of symptoms before initial diagnosis ranged from one week to one year. PSAMs occurred at cervical level in four, cervicothoracic in one and thoracolumbar in one. In addition, PSAMs presented isointensity on T1 weighted imaging (WI), hyperintensity on T2WI, and hetero- or homogeneously marked enhancement with contrast. Eight operations were performed in six patients. Simpson II resection was achieved in four (50%), Simpson IV in three (37.5%), Simpson V in one (12.5%). Adjuvant radiotherapy was performed in five patients. With a median survival time of 14 months (4–136 months), three patients had recurrence, two experienced metastases, and four died of respiratory failure. Conclusions PSAMs are a rare disease, and there is limited evidence as to the management of these lesions. They may metastasize, recur, and portend a poor prognosis. A close follow-up and further investigation are therefore necessary.

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“…In a case reported by Lambertz et al, [ 14 ] a patient with anaplastic meningioma developed multiple metastases in both lungs after the first surgery; this patient also had liver metastases. Nishida et al [ 5 ] reported an anaplastic meningioma in a very rare site, the spinal cord, with subsequent metastasis to the mediastinal lymph nodes. Moubayed et al [ 15 ] also reported a case of anaplastic meningioma metastasizing to the mediastinal lymph nodes.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1 ] It commonly occurs in the convex surface of the cerebrum, and in rare cases, in the parietal region, [ 3 ] brain parenchyma, [ 4 ] and spinal cord. [ 5 ]…”

Section: Introductionmentioning

confidence: 99%

A rare subtype of meningioma

et al. 2018

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Rationale:Anaplastic meningioma, a rare subtype of meningioma, has malignant morphological characteristics and a World Health Organization (WHO) grade of III.Patient concerns:In this report, we present findings from 6 cases of anaplastic meningioma.Diagnoses:Pathological examination of the tumors, including hematoxylin and eosin staining and immunohistochemical staining, was performed. Of the six cases of anaplastic meningioma, two were recurrent tumors from original seminoma with a WHO grade of I. Histologically, three cases had carcinoma-like morphology, one case had sarcoma-like morphology, and two had two kinds of tissue structures: carcinoma-like tumor cell nests and areas with spindle tumor cells. Necrosis was detected in most cases (5/6). Ki67 index was high and varied from 20% to 70%.Interventions:All the patients received surgery. 3 patients received adjuvant radiotherapy. 1 patient received chemotherapy.Outcomes:4 patients had no recurrence at follow-up of 19, 30, 46 and 54 months after the last surgery. 1 patient had recurrence 3 months after the last surgery. 1 patient died 12 days after the last surgery.Lessons:This malignant subtype can be secondary to a WHO grade I meningioma after a long quiescent period. Necrosis was common in the tumor tissues, and Ki67 index was usually high. For patients with a history of meningioma, including benign cases, regular physical examination is important for early detection of tumor recurrence and malignant transformation.

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A case of an anaplastic meningioma metastasizing to the mediastinal lymph nodes

Abstract: In cases of intramedullary spinal tumors with metastasis without other potential primary tumor lesions, early diagnosis and treatment should be performed while considering anaplastic meningioma.

Cited by 6 publications

References 44 publications

Delayed solitary mediastinal lymph node metastasis from a benign meningothelial meningioma six years after surgical resection of an intracranial tumor

Delayed solitary mediastinal lymph node metastasis from a benign meningothelial meningioma six years after surgical resection of an intracranial tumor

Clinical features and surgical outcomes of primary spinal anaplastic meningioma: a cases series and literature review

A rare subtype of meningioma

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