The article presents the results of a clinical analysis of the registered incidence of anthrax in the South of Kyrgyzstan. A pronounced tendency towards an increase in the incidence of anthrax with a wide distribution in disadvantaged stationary points of anthrax foci is shown. Despite the ongoing anti-epidemic and preventive measures, cases of the disease are registered annually among the population, mainly in the endemic territories of the republic. Anthrax in Kyrgyzstan among animals has been officially registered since ancient times, people are often involved in the epizootic cycle, among which the epidemic process is manifested by sporadic morbidity or a group outbreak of infection. The Kyrgyz Republic belongs to a permanently unfavorable region in terms of anthrax. At the same time, in the conditions of the south of Kyrgyzstan, as a result of natural disasters, many anthrax foci were washed away by mudflows, destroyed, lost, some of them remained on the territory of private property. Despite significant achievements in the study of the etiology, epidemiology, clinic, immunology, and prevention of anthrax, many theoretical and practical aspects of this set of tasks remain insufficiently studied, especially at the regional level. Significant changes in the living conditions of people, forms of management, uncontrolled slaughter of animals, imperfection in the diagnosis, treatment and prevention of this disease determine the relevance of studying anthrax in humans in modern conditions.