A Case of Autoimmune Retinopathy Associated with Thyroid Carcinoma

Mahdi, Nicole; Lisa, James R.; Goodwin, James; Nussenblatt, Robert B.; Sen, H. Nida

doi:10.3109/09273941003802379

Cited by 50 publications

(26 citation statements)

References 5 publications

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“…The primary tumor accounting for the vast majority is small-cell lung carcinoma, 48 followed by gynecologic (ovarian, endometrial, and cervical) 4, 70,140,185,207,230,246,251,255,264 and breast 17,68,182 malignancies. Less commonly reported solid tumor associations include non-small-cell lung, 248,253 prostate, 173 thymus, 124,229,274,293 thyroid, 166 pancreatic, 95 colon, 113 and bladder 173 cancers. Hematological malignancies (leukemia, lymphoma, myeloma) have also been linked to CAR.…”

Section: Clinical Presentationmentioning

confidence: 98%

“…Isolated cases have documented perivascular leakage and CME on FA. 17,109,140,171,208,230,272 Optical coherence tomography (OCT) typically reveals severe macular atrophy, often associated with thinning of the photoreceptor layer, 166,215 loss of the inner segment/outer segment (IS/OS) junction, 109 and loss of the inner highly reflective layer. 185, 255 Lima et al 157 advocated the additional use of fundus autofluorescence together with high-definition spectral domain OCT to aid in the diagnosis of this entity and monitoring for progression.…”

Section: Clinical Presentationmentioning

confidence: 99%

See 1 more Smart Citation

Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management

Rahimy¹,

Sarraf

2013

Survey of Ophthalmology

168

148

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Section: Clinical Presentationmentioning

confidence: 98%

Section: Clinical Presentationmentioning

confidence: 99%

Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management

Rahimy¹,

Sarraf

2013

Survey of Ophthalmology

168

148

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“…Associations with small-cell and non-small cell lung cancer, gynecological and breast cancers, Hodgkin's lymphoma, pancreatic, prostate, bladder, laryngeal and colon cancers have all been described 2. One case of a mixed thyroid adenoma/carcinoma-associated retinopathy has been published 3. Symptoms often precede the diagnosis of cancer.…”

Section: Discussionmentioning

confidence: 99%

Thyroid malignancy presenting with visual loss: an unusual case of paraneoplastic retinopathy

Hughes¹,

Moran

Flitcroft

et al. 2016

BMJ Case Reports

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Paraneoplastic retinopathy is a rare cause of painless vision loss, associated with an underlying (and often occult) systemic malignancy. Ocular examination findings are subtle, and the diagnosis is often made on the basis of electrophysiology findings. This report describes the case of a 48-year-old Caucasian man with paraneoplastic retinopathy presenting as visual disturbance, central scotomata and abnormal electrophysiology. He was subsequently diagnosed with papillary thyroid malignancy.

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“…The number of AR patients benefited from rituximab treatment (128–131). The efficacy of rituximab was studied in six patients (12 eyes) administrated as a monotherapy or in combination therapy (132).…”

Section: Management Of Autoimmune Retinopathiesmentioning

confidence: 99%

Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders

Adamus

2017

Front. Immunol.

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Autoantibodies (AAbs) against glycolytic enzymes: aldolase, α-enolase, glyceraldehyde-3-phosphate dehydrogenase, and pyruvate kinase are prevalent in sera of patients with blinding retinal diseases, such as paraneoplastic [cancer-associated retinopathy (CAR)] and non-paraneoplastic autoimmune retinopathies, as well as in many other autoimmune diseases. CAR is a degenerative disease of the retina characterized by sudden vision loss in patients with cancer and serum anti-retinal AAbs. In this review, we discuss the widespread serum presence of anti-glycolytic enzyme AAbs and their significance in autoimmune diseases. There are multiple mechanisms responsible for antibody generation, including the innate anti-microbial response, anti-tumor response, or autoimmune response against released self-antigens from damaged, inflamed tissue. AAbs against enolase, GADPH, and aldolase exist in a single patient in elevated titers, suggesting their participation in pathogenicity. The lack of restriction of AAbs to one disease may be related to an increased expression of glycolytic enzymes in various metabolically active tissues that triggers an autoimmune response and generation of AAbs with the same specificity in several chronic and autoimmune conditions. In CAR, the importance of serum anti-glycolytic enzyme AAbs had been previously dismissed, but the retina may be without pathological consequence until a failure of the blood–retinal barrier function, which would then allow pathogenic AAbs access to their retinal targets, ultimately leading to damaging effects.

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A Case of Autoimmune Retinopathy Associated with Thyroid Carcinoma

Abstract: This report highlights the unique presentation of AIR associated with a thyroid carcinoma, the need for continued surveillance for malignancy in cases of AIR, and the possible new use of rituximab for the treatment of AIR.

Cited by 50 publications

References 5 publications

Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management

Paraneoplastic and non-paraneoplastic retinopathy and optic neuropathy: Evaluation and management

Thyroid malignancy presenting with visual loss: an unusual case of paraneoplastic retinopathy

Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders

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