A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma

Kato, Atsushi; Yoshifuji, Ayumi; Komori, Kohji; Aoki, Kotaro; Taniyama, Daisuke; Komatsu, Motoaki; Fujii, Kentaro; Yamada, Kuniko; Ishii, Yoshikazu; Kikuchi, Takahide; Ryuzaki, Munekazu

doi:10.1016/j.jiac.2022.05.006

Cited by 18 publications

(21 citation statements)

References 15 publications

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“…natto and other species of B. subtilis rarely induce infection; however, there are several reports of infection by B. subtilis subsp. natto, such as bloodstream infections and meningitis in natto consumers 1–3,6 . To our knowledge, this case is the first report of community‐acquired pneumonia via this pathogen.…”

Section: Discussionmentioning

confidence: 75%

“…natto, such as bloodstream infections and meningitis in natto consumers. 1 , 2 , 3 , 6 To our knowledge, this case is the first report of community‐acquired pneumonia via this pathogen. The mechanism of pneumonia is unclear.…”

Section: Discussionmentioning

confidence: 75%

“…However, there have been several reports of severe infections in patients that consume natto caused by B. subtilis subsp. natto , particularly in cases of gastrointestinal perforation or immunocompromised individuals 1–3 . On the contrary, there are no reports of community‐acquired pneumonia in an immunocompetent host.…”

Section: Introductionmentioning

confidence: 99%

“…natto , particularly in cases of gastrointestinal perforation or immunocompromised individuals. 1 , 2 , 3 On the contrary, there are no reports of community‐acquired pneumonia in an immunocompetent host. We report a case of pneumonia and bacteremia caused by B. subtilis subsp .…”

Section: Introductionmentioning

confidence: 99%

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A case of community‐acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

Tani,

Takehara,

Ishioka

et al. 2024

Respirology Case Reports

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A 70‐year‐old immunocompetent male with a history of insomnia presented with pneumonia and bacteremia caused by Bacillus subtilis. The patient took benzodiazepines and regularly consumed alcohol and natto (fermented soybeans). Initial antibiotic treatment was not effective, and bronchoalveolar lavage was performed. Bronchoalveolar lavage fluid (BALF) analysis revealed an increased lymphocytes fraction, and B. subtilis was detected in the BALF. Whole‐genome sequencing confirmed the congruence of the genetic sequences between the strain in the blood culture of the patient, BALF, and strain isolated from the consumed natto, confirming B. subtilis subsp. natto as the causative pathogen of pneumonia and bacteremia. Vancomycin followed by levofloxacin and systemic corticosteroid were used to treat the condition. This case highlights community‐acquired pneumonia and bacteremia caused by B. subtilis subsp. natto, particularly in individuals who consume natto.

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Section: Discussionmentioning

confidence: 75%

Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A case of community‐acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

Tani,

Takehara,

Ishioka

et al. 2024

Respirology Case Reports

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“…Some strains of B. licheniformis isolated from food products showed the production of the surfactant lichenysin, a feature which would not comply with the QPS qualification ‘absence of cytotoxic activity’. Bacteraemia was diagnosed in a highly immunocompromised patient suffering from gut dysbiosis with a B. subtillis strain also present in fermented soya (natto), which was consumed daily by the patient (Kato et al., 2022 ). Haemolytic activity was discovered in some B. amyloliquefaciens (Dabire et al., 2022 ; Gauri et al., 2022 ) and B. subtilis (Dabire et al., 2022 ) strains; a property which is covered by the qualification ‘absence of toxigenic activity’ for Bacillus spp.…”

Section: Assessmentmentioning

confidence: 99%

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 17: suitability of taxonomic units notified to EFSA until September 2022

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2023

EFS2

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The qualified presumption of safety (QPS) approach was developed to provide a regularly updated generic pre‐evaluation of the safety of microorganisms, intended for use in the food or feed chains, to support the work of EFSA's Scientific Panels. The QPS approach is based on an assessment of published data for each agent, with respect to its taxonomic identity, the body of relevant knowledge and safety concerns. Safety concerns identified for a taxonomic unit (TU) are, where possible, confirmed at the species/strain or product level and reflected by ‘qualifications’. In the period covered by this Statement, new information was found leading to the withdrawal of the qualification ‘absence of aminoglycoside production ability’ for Bacillus velezensis. The qualification for Bacillus paralicheniformis was changed to ‘absence of bacitracin production ability’. For the other TUs, no new information was found that would change the status of previously recommended QPS TUs. Of 52 microorganisms notified to EFSA between April and September 2022 (inclusive), 48 were not evaluated because: 7 were filamentous fungi, 3 were Enterococcus faecium , 2 were Escherichia coli , 1 was Streptomyces spp., and 35 were taxonomic units (TUs) that already have a QPS status. The other four TUs notified within this period, and one notified previously as a different species, which was recently reclassified, were evaluated for the first time for a possible QPS status: Xanthobacter spp. could not be assessed because it was not identified to the species level; Geobacillus thermodenitrificans is recommended for QPS status with the qualification ‘absence of toxigenic activity’. Streptoccus oralis is not recommended for QPS status. Ogataea polymorpha is proposed for QPS status with the qualification ‘for production purposes only’. Lactiplantibacillus argentoratensis (new species) is included in the QPS list.

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Synthesis of Acetylene‐Functionalized Schiff base for Selective Detection of Al(III) and Exploring Its Antibacterial Properties via In Silico and In Vivo Approach

Singh,

Mithun,

Devi

et al. 2024

ChemistrySelect

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The identification of perilous metal ions and the treatment of diseases induced by microorganisms are critical areas requiring attention. We report herein the design and development of an acetylene‐functionalized Schiff base compound 4, using a low‐cost and straightforward approach. This compound 4 exhibits dual functions in the detection of harmful metal ions, particularly Al(III), as well as in the prevention of disorders caused by bacteria, specifically Staphylococcus aureus (S. aureus) and Bacillus subtilis (B. subtilis). It was well characterized through the utilization of diverse spectroscopic techniques, such as NMR (1H and 13C), FT‐IR, and mass spectrometry. Furthermore, the complete structure clarification of the Schiff base compound 4 was revealed through the utilization of X‐ray crystallography. The limit of detection (LOD) for Al(III) is 35.5 × 10−8 M, surpassing the WHO drinking water standard of 26.7 µM, underscoring the high sensitivity of compound 4. The antibacterial activity of compound 4 has also been effectively evaluated on Gram‐positive (S. aureus and B. subtilis) bacteria. Furthermore, compound 4 was docked to S. aureus and B. subtilis proteins, which represents outstanding outcomes with binding energies of −7.31 kcal/mol and −7.87 kcal/mol, respectively. The antibacterial activity of the compound 4 in both in vitro and docking studies suggests that it possesses the potential to serve as an antibacterial agent in the future.

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A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma

Cited by 18 publications

References 15 publications

A case of community‐acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

A case of community‐acquired pneumonia caused by Bacillus subtilis subsp. natto in an immunocompetent patient

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 17: suitability of taxonomic units notified to EFSA until September 2022

Synthesis of Acetylene‐Functionalized Schiff base for Selective Detection of Al(III) and Exploring Its Antibacterial Properties via In Silico and In Vivo Approach

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