A case of Cantrell syndrome diagnosed in the first trimester

Delibaş, İlhan Bahri; İsaoğlu, Ünal; Tanrıverdi, Esra Çınar; Yilmaz, Mahmut Muhsin

doi:10.12891/ceog3065.2016

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Sternal malformations Sternal malformations were described in one third of the cases (23 patients, 34.32%). The defective formation of the lower half of the sternum (cleft defect) was present in 20 fetuses [6,11,16,18,19,26,28,31,34,35,40,48,50,57], while complete sternal aplasia was found in 3 cases [8,9,38].…”

Section: Abdominal Wall Defectsmentioning

confidence: 99%

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Cantrell syndrome in the first trimester of pregnancy: imagistic findings and literature review

et al. 2020

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Pentalogy of Cantrell (POC) is a rare condition characterized by complete or partial expression of 5 types of congenital birth defects originating in (1) the lower sternum, (2) the anterior diaphragm, (3) the diaphragmatic pericardium, (4) the midline/ventral supraumbilical abdominal wall region, and (5) the heart. POC can be diagnosed antenatally by means of ultrasonography (US), the task being difficult if defects are minor. Advances in the field of US and the introduction of the first morphology trimester as state-of-the-art pregnancy monitoring, facilitate the early diagnosis of this condition. We performed a systematic review on 67 reported cases of POC diagnosed in the first trimester of pregnancy (published from January 1980 to July 2019). The aim of our systematic review was twofold: to assess the main US findings in the first trimester of pregnancy and to increase awareness of early diagnostic possibilities. Our study showed that POC can be diagnosed in the first trimesterof pregnancy based on key US findings such as the association between omphalocele and ectopia cordis. When these two anomalies are present, increased nuchal translucency can also be considered a marker of POC in the first trimester.

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Section: Abdominal Wall Defectsmentioning

confidence: 99%

“…Diaphragmatic and pericardial defects Diaphragmatic and pericardial defects were noted in utero in 11 fetuses (16.41%) [14,16,35,38,[48][49][50] and in 10 cases (14.92%), respectively [14,16,32,35,48,50].…”

Section: Abdominal Wall Defectsmentioning

confidence: 99%

Cantrell syndrome in the first trimester of pregnancy: imagistic findings and literature review

et al. 2020

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Pentalogía de Cantrell. Reporte de un caso en el Hospital San Vicente de Paúl de Ibarra, Ecuador

Haro¹

2021

Clínica e Investigación en Ginecología y Obstetricia

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Megacystis in the first trimester of pregnancy: Prognostic factors and perinatal outcomes

et al. 2021

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Objective To determine whether bladder size is associated with an unfavorable neonatal outcome, in the case of first-trimester megacystis. Materials and methods This was a retrospective observational study between 2009 and 2019 in two prenatal diagnosis centers. The inclusion criterion was an enlarged bladder (> 7 mm) diagnosed at the first ultrasound exam between 11 and 13+6 weeks of gestation. The main study endpoint was neonatal outcome based on bladder size. An adverse outcome was defined by the completion of a medical termination of pregnancy, the occurrence of in utero fetal death, or a neonatal death. Neonatal survival was considered as a favorable outcome and was defined by a live birth, with or without normal renal function, and with a normal karyotype. Results Among 75 cases of first-trimester megacystis referred to prenatal diagnosis centers and included, there were 63 (84%) adverse outcomes and 12 (16%) live births. Fetuses with a bladder diameter of less than 12.5 mm may have a favorable outcome, with or without urological problems, with a high sensitivity (83.3%) and specificity (87.3%), area under the ROC curve = 0.93, 95% CI (0.86–0.99), p< 0.001. Fetal autopsy was performed in 52 (82.5%) cases of adverse outcome. In the 12 cases of favorable outcome, pediatric follow-up was normal and non-pathological in 8 (66.7%). Conclusion Bladder diameter appears to be a predictive marker for neonatal outcome. Fetuses with smaller megacystis (7–10 mm) have a significantly higher chance of progressing to a favorable outcome. Urethral stenosis and atresia are the main diagnoses made when first-trimester megacystis is observed. Karyotyping is important regardless of bladder diameter.

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A case of Cantrell syndrome diagnosed in the first trimester

Cited by 3 publications

References 6 publications

Cantrell syndrome in the first trimester of pregnancy: imagistic findings and literature review

Cantrell syndrome in the first trimester of pregnancy: imagistic findings and literature review

Pentalogía de Cantrell. Reporte de un caso en el Hospital San Vicente de Paúl de Ibarra, Ecuador

Megacystis in the first trimester of pregnancy: Prognostic factors and perinatal outcomes

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