A case of carcinoma myxomatodes of the testis occurring in infancy

White, Charles Powell

doi:10.1002/path.1700140410

Cited by 25 publications

(6 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These "benign-type" postpubertal teratomas are entirely analogous to the prepubertal teratomas, with identical morphologic features and unremarkable outcomes after surgery alone. In a study of 15 patients, all postpubertal, as determined by the finding of active spermatogenesis in the testis, six patients were less than 20 years old (range: [12][13][14][15][16][17][18]. 70 These teratomas differed from dermoid cysts (see below) in that they lacked cutaneous elements.…”

Section: Teratomamentioning

confidence: 96%

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades

Ulbright

Young

2014

Seminars in Diagnostic Pathology

View full text Add to dashboard Cite

Section: Teratomamentioning

confidence: 96%

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades

Ulbright

Young

2014

Seminars in Diagnostic Pathology

View full text Add to dashboard Cite

“…A teratoid tumour found in both gonadal and extragonadal locations, YSTs have been known under different names over time. A century ago, White 4 identified them as ‘ carcinoma myxomatodes ’, while some authors considered them neoplasms of unknown histogenesis, naming them ‘ adenocarcinoma of the testis ’ 5 or ‘ infantile adenocarcinoma of the testis ’ 6 . For many years, the most popular term for ovarian YSTs was coined by Schiller 7 who used the term ‘ mesonephroma ovarii ’, since its sinusoidal structures were interpreted as being similar to mesonephric glomeruli.…”

Section: Historical Development Of the Yst Conceptmentioning

confidence: 99%

Yolk sac tumours revisited. A review of their many faces and names

2011

View full text Add to dashboard Cite

We review the current knowledge on human yolk sac tumours (YSTs) 50 years after their initial description. Their complex nomenclature and histogenesis stress the fact that they are not a discrete entity, but represent a multifaceted group of neoplasms, for which the term primitive endodermal tumours would be more appropriate, accounting for their capacity to differentiate into various extraembryonal and somatic cell types. Different histological patterns of human YSTs correlate with the developmental potential of primitive endoderm and mesenchyme, but they are also similar to some murine experimental tumours. Exceptionally, YSTs replicate the tubular structures of the human yolk sac and allantois. Endodermal somatic differentiation reproduces pulmonary, intestinal and hepatic tissues and are identical with some, embryonal-type endodermal, gastric and lung carcinomas, which are indistinguishable from YSTs. YSTs may show an overgrowth of their mesenchymal (sarcomatous) and epithelial components (such as mucinous carcinoma or carcinoid) and also be a source of haematological malignancies. YSTs associated with non-germ cell tumours probably originate from malignant pluripotent somatic stem cells. Only AFP and glypican-3 are characteristic immunohistochemical markers. Pluripotent antibodies (SALL4, Lin28, IMP-3) help in differential diagnoses, while some differentiation markers (CDX2, TTF-1, HepPar1) facilitate recognition of unusual variants of YSTs.

show abstract

“…The first recognisable example of pure yolk sac tumour of the testis can be found in the British literature in 1910. 38 That tumour occurred in an infant, and the fact that this was a unique tumour of the testis of young boys, particularly when seen in pure form, was highlighted in the 1950s by Magner et al 39 and in 1960 by Teoh et al 40 The largest series of paediatric cases has recently been published. 41 Teilum's work on the yolk sac tumour is so well known that it sometimes causes his other work on testicular tumours, particularly sex cord tumours, to be overlooked.…”

Section: The Testismentioning

confidence: 99%

“…The yolk sac tumour is one of the most interesting of all testicular neoplasms, and knowledge about it is, in great part, due to the Danish pathologist Dr Gunnar Teilum (Figure ), who established its germ cell nature, dating back to his seeing yolk sac tumour (or, as he preferred to call it, endodermal sinus tumour) as a component of mixed germ cell tumours of the testis. The first recognisable example of pure yolk sac tumour of the testis can be found in the British literature in 1910 . That tumour occurred in an infant, and the fact that this was a unique tumour of the testis of young boys, particularly when seen in pure form, was highlighted in the 1950s by Magner et al .…”

Section: The Testismentioning

confidence: 99%

The history of urologic pathology: an overview

Young

Eble

2018

Histopathology

View full text Add to dashboard Cite

This article begins with the testis and a legendary figure, Sir Astley Cooper, who wrote an early text on the organ. The early 20th century saw the first major development, the description of the seminoma by the French investigator Maurice Chevassu, but the pace of knowledge did not accelerate until after World War II with a major article from the Armed Forces Institute of Pathology (AFIP) by Nathan B. Friedman and Robert A. Moore, soon followed by the first series testis fascicle by Frank J. Dixon and Moore. Other noteworthy contributions were made by two masters of gonadal pathology, Gunnar Teilum and Robert E. Scully. In the 1970s, Niels E. Skakkebaek played a seminal role in elaborating in‐situ neoplasia of the testis. The school of British testicular tumour authored, in the mid‐1970s, under the editorship of Roger C. B. Pugh, one of the best texts on testicular pathology. Advances in more recent years have been largely spearheaded by Thomas M. Ulbright of the Indiana University School of Medicine. Observations on the prostate gland date back to Andreas Vesalius and William Cheselden, the latter appearing to have introduced the word for the gland. Note is made of contributions on the anatomy and histology of the gland by Oswald Lowsley, L. M. Franks, and John McNeal. Diagnosing carcinoma of the prostate was brought into the modern age in a landmark 1953 article by Robert S. Totten et al. In the 1960s, Donald F. Gleason introduced a grading system that is now in use worldwide. The topic of premalignant lesions has been well established only for approximately three decades, based initially on the work of Dr McNeal and David G. Bostwick. One of the first to write a book on the bladder was the remarkable British surgeon‐pathologist Sir Henry Thompson. Workers at the AFIP, including Colonel James E. Ash and Fatallah K. Mostofi, wrote many outstanding articles on bladder pathology. The roles of other institutions, such as Johns Hopkins University, the Mayo Clinic, and St Peter's Hospital Institute of Urology, London, and those who worked there are noted. Knowledge of the pathology of the urachus dates largely back to the remarkable book on the topic in 1916 by the Hopkins investigator Thomas S. Cullen. Information on renal tumours dates largely to the work of Paul Grawitz, but awareness of the many variants of renal cell carcinoma in general was slow to evolve, and has only accelerated in recent years. The AFIP group of Dr Mostofi, ably assisted by Colonel Charles J. Davis and Isabell A. Sesterhenn, has contributed to knowledge of renal neoplasia with articles of note on oncocytoma, metanephric adenoma, and medullary carcinoma. In the mid‐1980s, the German workers Wolfgang Thoenes and Stephan Störkel recognised the distinctive tumour known as chromophobe renal cell carcinoma. Work on renal tumours in the young owes much to J. Bruce Beckwith. The observational talents of numerous investigators have, in just over a century, advanced our knowledge of diseases of the urinary tract and testis remarkably.

show abstract

A case of carcinoma myxomatodes of the testis occurring in infancy

Cited by 25 publications

References 1 publication

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades

Testicular and paratesticular tumors and tumor-like lesions in the first 2 decades

Yolk sac tumours revisited. A review of their many faces and names

The history of urologic pathology: an overview

Contact Info

Product

Resources

About