A case of carcinoma of the colon in association with neurofibromatosis

Jenkins, D. H. R.; Gill, William J.

doi:10.1002/bjs.1800590417

Cited by 29 publications

(21 citation statements)

References 6 publications

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“…Adenocarcinomas of the esophagus (63), stomach (64), colon (65,66), small intestine (67)(68)(69)(70)(71)(72), pancreas (72,73), gallbladder (74), and bile ducts (74,75) have been reported in patients with NF1. Taking into consideration the prevalence of these cancers in the general population, the association of adenocarcinomas in the colon, esophagus, stomach, biliary tract, and pancreas with NF1 may be incidental.…”

Section: Adenocarcinomamentioning

confidence: 98%

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Levy¹,

Patel²,

Dow³

et al. 2005

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Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders. NF1 is a complex disease resulting from a spectrum of mutations that may occur at many locations along the large, complex NF1 gene, which is located on chromosome 17. Mutations of the NF1 gene lead to abnormal tumor suppression. Consequently, patients with NF1 have an increased prevalence of benign and malignant neoplasms throughout the body. There are five categories of NF1 tumors that occur in the abdomen: neurogenic, neuroendocrine, nonneurogenic gastrointestinal mesenchymal, embryonal, and miscellaneous. Many of these tumors are age related, occur at specific anatomic locations, and have unique imaging features. Notably, many patients have a variety of organs affected because there is a high prevalence of multiple tumors occurring in the same patient. Neurofibromas are the most common benign neoplasms and may occur in the retroperitoneum or visceral organs. Malignant peripheral nerve sheath tumor is an aggressive malignancy that is the most common malignant tumor of the abdomen in patients with NF1. Interpreting abdominal imaging studies in patients with NF1 can be challenging because of the wide spectrum and diverse nature of tumors that occur in this disease.

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Section: Adenocarcinomamentioning

confidence: 98%

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Levy¹,

Patel²,

Dow³

et al. 2005

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112

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“…Neurofibromatosis may also be associated with other malignant tumours such as carcinoid of the ampulla of Vater (Barber, 1976), adenocarcinoma of the pancreas (Kellar and Logan, 1977), adenocarcinoma of the colon (Jenkins and Gill, 1972), Wilms' tumour (Stay and Vauter, 1977), rhabdomyosarcoma (McKeen and Bodurtha, 1978) and leukaemia (Bader and Miller, 1978). The authors wish to report the association of primary adenocarcinoma of the duodenum in a young man suffering from cutaneous neurofibromatosis.…”

Section: Introductionmentioning

confidence: 99%

Primary adenocarcinoma of the duodenum associated with cutaneous neurofibromatosis (von Recklinghausen’s disease)

McGlinchey¹,

Santer²,

Haqqani³

1982

Postgraduate Medical Journal

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“…This is the fourth report in the medical literature describing adenocarcinoma of the colon in the presence of neurofibromatosis. [2][3][4] There also have been seven case reports in the literature that indicate an association between neurofibromatosis and small-bowel adenocarcinoma. 5 It has been suggested that there is an association with adenocarcinoma of the stomach, 6 oesophagus, 7 and pancreas.…”

Section: Discussionmentioning

confidence: 94%

“…There are, however, only three case reports that indicate an association with adenocarcinoma of the colon. [2][3][4] This case report provides further evidence of a link between neurofibromatosis and adenocarcinoma of the colon.…”

mentioning

confidence: 86%

Colonic Vascular Anomalies and Colon Cancer in Neurofibromatosis: Report of a Case

Wood¹,

Longman²,

Rooney³

et al. 2008

Diseases of the Colon &Amp; Rectum

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We report a case of neurofibromatosis with synchronous adenocarcinomas in the sigmoid and transverse colon. There was widespread intimal proliferation in arteries in the region of the tumors and also in the cecum. Such vascular lesions are associated with von Recklinghausen's disease. The cecal lesion produced mural thickening visible on computed tomography. This case supports a possible genetic link between neurofibromatosis and adenocarcinoma of the colon.

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A case of carcinoma of the colon in association with neurofibromatosis

Abstract: A case is presented of neurofibromatosis of the large bowel associated with a primary adenocarcinoma of the colon. This is believed to be the first report of such an association.

Cited by 29 publications

References 6 publications

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Abdominal Neoplasms in Patients with Neurofibromatosis Type 1: Radiologic-Pathologic Correlation

Primary adenocarcinoma of the duodenum associated with cutaneous neurofibromatosis (von Recklinghausen’s disease)

Colonic Vascular Anomalies and Colon Cancer in Neurofibromatosis: Report of a Case

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