SUMMARYWe present the first Love-wave group velocity and shear velocity maps of the British Isles obtained from ambient noise interferometry and fully non-linear inversion. We computed interferometric inter-station Green's functions by cross-correlating the transverse component of ambient noise records retrieved by 61 seismic stations across the UK and Ireland. Group velocity measurements along each possible inter-station path were obtained using frequency-time analysis and converted into a series of inter-station traveltime datasets between 4 and 15 seconds period. Traveltime uncertainties estimated from the standard deviation of dispersion curves constructed by stacking randomly-selected subsets of daily cross-correlations, were observed to be too low to allow reasonable data fits to be obtained during tomography. Data uncertainties were therefore estimated again during the inversion as distance-dependent functionals. We produced Love-wave group velocity maps within 8 different period bands using a fully non-linear tomography method which combines the transdimensional reversible-jump Markov chain Monte Carlo (rj-McMC) algorithm with an

complete remission-1/25 (4%), partial remission-7/25 (28%), stable disease-6/25 (24%), and progressive disease-11/25 (44%), for an overall response rate of 8/25 (32%). Median duration of response was 6 months. Toxicities included hand-foot syndrome, mucositis, diarrhea, and nausea and vomiting, and required treatment interruption and/or dose attenuation in 9/25 patients (36%). No myelosuppression or serious catheter-related problems were seen. We conclude that continuous 5 FU infusion is a potentially effective salvage treatment that may provide meaningful palliation in some patients with carcinoma of the breast, in spite of extensive previous treatment.

A case is presented of neurofibromatosis of the large bowel associated with a primary adenocarcinoma of the colon. This is believed to be the first report of such an association.

To delineate the efficacy of continuous intravenous 5-fluorouracil (5-FU) infusion therapy for advanced colorectal adenocarcinoma, a study of 36 patients with measurable metastatic disease was conducted. Patients received a daily intravenous infusion of 300 mg/m2 5-FU over a 24-h period utilizing portable infusion devices and central venous catheters. In a population characterized by substantial pretreatment exposure to radiotherapy, chemotherapy, and other indicators of poor prognosis, 13/36 (36%) patients achieved an objective response. An additional 10/36 (28%) patients manifested stable disease (no change) and experienced survival comparable to that of patients with objective response. Toxicity was minimal; patients were able to continue 5-FU infusions 95% of the total time on protocol. There were no adverse hematologic effects or catheter complications. Because previously untreated patients benefited more frequently (positive response, 50%), continuous intravenous infusion should be evaluated further as a primary modality option when 5-fluorouracil antitumor chemotherapy is contemplated.