A case of chronic myeloid leukemia with the m-bcr (p190) molecular rearrangement identified during treatment

Asinari, Mariana Beatriz; Zeballos, Maximiliano; Alicia, Sturich; Ricchi, Brenda; Basquiera, Ana Lisa

doi:10.1016/j.bjhh.2014.07.024

Cited by 5 publications

(3 citation statements)

References 12 publications

(16 reference statements)

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“…To avoid the misdiagnosis of CML as CMML, it was proposed that the absence of relative monocytosis (a PB monocyte frequency of >8%; it was 8.5% in the present case) should be a criterion for the diagnosis of CML when the total number of leukocytes is higher than 20×10 9 /L ( 25 ). Ph-positive CML rarely expresses the p190 BCR-ABL transcript, which is often accompanied by prominent monocytosis and a hematological phenotype that is intermediate between those of CML and CMML ( 27 - 29 ). In our case, the conventional p210 BCR-ABL transcript, but not the p190 BCR-ABL transcript, was detected during an analysis based on the reverse transcription polymerase chain reaction.…”

Section: Discussionmentioning

confidence: 99%

A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow

et al. 2017

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A 48-year-old man was admitted due to marked leukocytosis. Bone marrow examinations resulted in a diagnosis of Philadelphia (Ph) chromosome-positive chronic myeloid leukemia. One month later, massive muscle and bone invasion by leukemic cells was detected. After induction chemotherapy, he complained of a headache and visual loss, which was caused by a leukemic infiltration in the central nervous system. After temporary remission in response to chemotherapy, the disease relapsed in the form of an intracranial tumor. The unusual t(14;22)(q24;q11.2) translocation of the Ph-chromosome and the significant increase in monocytes observed might have contributed to the unique and aggressive clinical course.

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Section: Discussionmentioning

confidence: 99%

A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow

et al. 2017

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“…This rare fusion transcript, also known as minor breakpoint cluster region (m-bcr), codes for a smaller (190kDa) oncoprotein with a unique clinical presentation between CML and chronic myelomonocytic leukemia (CMML). 4 …”

Section: Introductionmentioning

confidence: 99%

Coexistence of P190 BCR/ABL transcript and CALR 52-bp deletion in chronic myeloid leukemia blast crisis: a case report

Saki

Seghatoleslami

Ketabchi

et al. 2016

Mediterr J Hematol Infect Dis

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We introduce a 78-year-old woman presented with thrombocytosis and high blast count who had a history of splenectomy. Her cytogenetic analysis revealed aberrant chromosomal rearrangements in different clonal populations harboring 46XX karyotype with t(9;22) (q34;q11). RT-PCR assay detected the e1a2 BCR-ABL translocation resulting from rearrangement of the minor breakpoint cluster region (m-bcr) in BCR gene. Subsequent evaluation of the disease showed calreticulin (CALR) 52-bp deletion as well as the absence of JAK2V617F heterozygous mutation in granulocyte population of peripheral blood using allele-specific PCR and bi-directional DNA sequencing. To our knowledge, this is the first case of a patient initially diagnosed as p190 BCR-ABL transcript positive CML in blast crisis characterized by a 52-bp deletion in CALR gene.

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“…TO THE EDITOR: Minor BCR-ABL1 -positive chronic myeloid leukemia (CML) is a very rare subtype of CML, with only 1–2% of patients with CML exhibiting this fusion gene as a sole rearrangement [ 1 ]. Amongst the several reported cases in literature, and to the best of our knowledge, only one case has been reported in Korea so far [ 2 ].…”

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confidence: 99%

A case of e1a2 (minor, P190) BCR-ABL1-positive chronic myeloid leukemia in Korea

Choi

Heo²,

Yoo

2021

Blood Res

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A case of chronic myeloid leukemia with the m-bcr (p190) molecular rearrangement identified during treatment

Cited by 5 publications

References 12 publications

A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow

A Rare Monocytic Crisis of Chronic Myelogenous Leukemia Presenting with Unusual Extramedullary Manifestations and an Atypical (14;22)(q24;q11.2) Translocation in the Bone Marrow

Coexistence of P190 BCR/ABL transcript and CALR 52-bp deletion in chronic myeloid leukemia blast crisis: a case report

A case of e1a2 (minor, P190) BCR-ABL1-positive chronic myeloid leukemia in Korea

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