A case of Churg-Strauss syndrome without peripheral blood eosinophilia

Nagao, Y.; Ueda, Shuichiro; Kajimoto, Atsuko; Nakanishi, Ritshuko; Nishiyama, Yasuyuki; Yamanaka, Hiromi; Harada, Hiromasa

doi:10.12659/ajcr.882094

Cited by 2 publications

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“…Second, because small studies with negative results are less likely to published, the possibility of publication bias cannot be completely ruled out, even though the Egger’s test and funnel plots did not show evidence of publication bias in this meta-analysis. Third, a lack of original data from the eligible studies limited evaluation of the effects of the gene-gene and gene-environment interactions during pediatric asthma development [ 25 – 28 ].…”

Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of IL-13 Polymorphisms and Pediatric Asthma Risk

Liu

Wang

et al. 2014

Med Sci Monit

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BackgroundIL13–1112C/T and +2044A/G polymorphisms have been reported to be correlated with pediatric asthma susceptibility, but study results were still debatable. Thus, a meta-analysis was conducted.Material/MethodsPubMed and EMBASE databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model or fixed-effects model.ResultsFourteen case-control studies with 4710 asthma cases and 6086 controls were included in this meta-analysis. IL13–1112C/T and +2044A/G polymorphisms were significantly associated with an increased risk of pediatric asthma (OR=1.14, 95% CI 1.01–1.28, P=0.04, I2=0%; OR=1.20, 95% CI 1.09–1.32, P<0.01, I2=0%), respectively. In the subgroup analysis by ethnicity, IL13–1112C/T polymorphism was significantly associated with pediatric asthma risk in whites (OR=1.29, 95% CI 1.02–1.63, P=0.03, I2=16%). IL13 +2044A/G polymorphism was significantly associated with pediatric asthma risk in Asians (OR=1.21, 95% CI 1.10–1.34, P<0.01, I2=24%).ConclusionsThe results of this meta-analysis suggest that IL13–1112C/T and +2044A/G polymorphisms contribute to the development of pediatric asthma.

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Section: Discussionmentioning

confidence: 99%

A Meta-Analysis of IL-13 Polymorphisms and Pediatric Asthma Risk

Liu

Wang

et al. 2014

Med Sci Monit

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Otologic Manifestations of Eosinophilic Granulomatosis With Polyangiitis: A Systematic Review

Ashman

Chen

Barinsky

et al. 2020

Otology &Amp; Neurotology

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Objective: To perform a systematic review of the diagnosis, treatment, and management of patients with otologic manifestations of eosinophilic granulomatosis with polyangiitis. Databases Reviewed: PubMed, Embase, Cochrane. Methods: A systematic search for relevant published literature in PubMed, Cochrane Library, and EMBASE databases was done. Data was collected on demographics, otologic manifestations, specific diagnostic criteria fulfilled, common clinical, and imaging findings as well as medical and surgical treatments received. Results: Fifteen articles encompassing 219 patients met inclusion criteria including 8 case reports and 7 case series. The mean age was 52.8 (range of 24–70). The most common otologic presenting symptoms were hearing loss (76%), otitis media with effusion (44%), vertigo (22%), tinnitus (21%), and chronic otitis media (20%). The most common diagnostic criteria observed in these patients were paranasal sinus abnormalities (75%), asthma (66%), and eosinophilia >10% (44%). The most common treatment was systemic steroids (66%), followed by surgery (52%), with myringotomy with tube insertion (M&T) (32%) and endoscopic sinus surgery (21%) being the most prevalent. Thirty-four percent of patients received an immunosuppressive agent. Successful treatments included systemic steroids (23%), surgical modalities (13%) with M&T being the most common (7%), topical nasal steroids (12%), and cyclophosphamide (10%). Conclusion: Hearing loss and a middle ear effusion are the most common presenting otologic manifestations of eosinophilic granulomatosis with polyangiitis. Sinonasal disease was more prevalent in patients with otologic manifestations. Primary treatment consists of systemic steroids and immunomodulation. M&T, endoscopic sinus surgery, and local steroid administration can be adjunctive measures to alleviate local disease. Level of Evidence: Level 1

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A case of Churg-Strauss syndrome without peripheral blood eosinophilia

Cited by 2 publications

References 0 publications

A Meta-Analysis of IL-13 Polymorphisms and Pediatric Asthma Risk

A Meta-Analysis of IL-13 Polymorphisms and Pediatric Asthma Risk

Otologic Manifestations of Eosinophilic Granulomatosis With Polyangiitis: A Systematic Review

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