1993
DOI: 10.1111/j.1346-8138.1993.tb03827.x
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A Case of Cutaneous B‐cell Lymphoma Treated Successfully with MACOP‐B

Abstract: A case of cutaneous B-cell lymphoma successfully treated by MACOP-B therapy is described. The patient was a 43-year-old man with reddish tumors measuring 3 to 7 cm in diameter on the right cheek and the post-auricles. Histopathologically, massive infiltrations of medium-sized atypical lymphoid cells were found in the reticular dermis and subcutis. A clear zone beneath the epidermis was also detected. The atypical lymphoid cells were positive for CD19, CD20, CD22 and HLA-DR but negative for CD3, CD4, CD5, CD10,… Show more

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Cited by 7 publications
(4 citation statements)
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“…CHOP regimen appears to be preferred to COP as it reduces relapse rates (43). A case has been successfully treated with MACOP‐B polychemoterapy showing a good response and a DFS of more than 3 yr (45). Even the systemic administration of rituximab appears a good chance, in particular, in the elderly; in very aggressive or in plurirelapsing lymphomas, in case with systemic involvement, the combination of rituximab with anthracycline‐containing chemotherapies may be proposed, even if data about response and prolonged follow‐up are still lacking (17, 31).…”
Section: Discussionmentioning
confidence: 99%
“…CHOP regimen appears to be preferred to COP as it reduces relapse rates (43). A case has been successfully treated with MACOP‐B polychemoterapy showing a good response and a DFS of more than 3 yr (45). Even the systemic administration of rituximab appears a good chance, in particular, in the elderly; in very aggressive or in plurirelapsing lymphomas, in case with systemic involvement, the combination of rituximab with anthracycline‐containing chemotherapies may be proposed, even if data about response and prolonged follow‐up are still lacking (17, 31).…”
Section: Discussionmentioning
confidence: 99%
“…Patients with leg or widespread lesions showed a higher relapse rate (55 vs. 26%) than those with trunk or head lesions. The use of another type of chemotherapy, that is MACOP‐B (methotrexate with leucovorin, doxorubicin, cyclophosphamide, vincristine, prednisone, and bleomycin), has been reported in one case with a good clinical response and a disease‐free interval for more than 3 years 11 …”
Section: Different Methods Of Treatmentmentioning
confidence: 99%
“…Eine Chemotherapie (6 Zyklen ᭤ CHOP, COP, MACOP) kann zur Regression (PR, CR) des Befundes führen [8,15,16] und sollte unter nachfolgender Anwendung von Interferon a2a (3×3 Mio IE pro Woche) oder Anti-CD20-Antikörper Rituximab als Erhaltungstherapie stabilisiert werden. Eine Chemotherapie (6 Zyklen ᭤ CHOP, COP, MACOP) kann zur Regression (PR, CR) des Befundes führen [8,15,16] und sollte unter nachfolgender Anwendung von Interferon a2a (3×3 Mio IE pro Woche) oder Anti-CD20-Antikörper Rituximab als Erhaltungstherapie stabilisiert werden.…”
Section: Systemische Therapieunclassified