A case of cutaneous myoepithelial carcinoma

Tanahashi, Jin; Kashima, Kenji; Daa, Tsutomu; Kondo, Yoshiyuki; Kuratomi, Eiji; Yokoyama, Shigeo

doi:10.1111/j.1600-0560.2006.00676.x

Cited by 36 publications

(45 citation statements)

References 17 publications

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“…The syncytial variant of cutaneous myoepithelioma appears to behave in a benign manner, and the standard treatment is complete excision with negative margins (1,2). The criteria for diagnosing a cutaneous myoepithelial carcinoma have not been well established, however, tumors exhibiting cytological atypia, a high mitotic rate and necrosis have been shown to behave in a more aggressive fashion (2,(6)(7)(8).…”

Section: Discussionmentioning

confidence: 99%

Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors

et al. 2015

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Abstract. Cutaneous myoepithelioma is a peculiar and recently recognized neoplasm exhibiting purely myoepithelial differentiation. These lesions affect different areas of the body, and are characterized by heterogenous morphological and immunophenotypical features. The majority of cutaneous myoepitheliomas behave in a benign fashion, however, the risk for local recurrence is higher with incomplete resection. A relatively newly described variant of myoepithelioma exhibits syncytial cytological features. The current study reports a case of cutaneous syncytial myoepithelioma presenting as a painless and papular skin lesion. The presence of the Ewing sarcoma RNA-binding protein 1 gene rearrangement in the present case supported the diagnosis of a myoepithelial tumor. The patient subsequently underwent local excision of the tumor and was followed up twice in the year after surgery. At the time of writing, the patient was alive and no recurrences had been identified. Furthermore, the current study discusses how this myoepithelial neoplasm may be distinguished from other problematic spindle or epithelioid cell tumors, particularly superficial dermal lesions.

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Section: Discussionmentioning

confidence: 99%

Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors

et al. 2015

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“…Malignant cutaneous mixed tumors (myoepithelial carcinomas) may be considered a rare variant of carcinosarcoma, which show true biphasic differentiation, as they appear to be derived from pluripotent stem cells, which give rise to both mesenchymal and epithelial cell types. [13][14][15] Although pleomorphic sarcoma-like areas have not been described in these tumors, the current case showed areas of both epithelial (including ductal) and mesenchymal differentiation, as well as positive staining for immunohistochemical markers including S-100, calponin, and actin, findings supportive of myoepithelial differentiation.…”

Section: Discussionmentioning

confidence: 78%

Cutaneous Carcinosarcoma With Myoepithelial Differentiation: Immunohistochemical and Cytogenetic Analysis of a Case Presenting in an Unusual Location

Smart¹,

Pucci²,

Binder³

2009

The American Journal of Dermatopathology

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Primary cutaneous carcinosarcoma is an uncommon tumor that is characterized by an admixture of malignant epithelial and mesenchymal elements. To our knowledge, only approximately forty cases have been reported to date in the literature. The majority of these neoplasms occurred on the extremities and the head and neck region of older individuals. We report an additional case, which presented in an 87-year-old man in an unusual location, the buttock. Histologically, the lesion was characterized by a biphasic proliferation of malignant epithelial areas admixed with an infiltrative, poorly differentiated spindle cell component. The epithelial areas consisted of nodular aggregates of basaloid to squamoid cells forming focal ductal structures with central lumens containing proteinaceous debris. The sarcomatoid component consisted of malignant spindle to epithelioid-appearing cells admixed with bizarre-appearing tumor giant cells within a myxochondroid stroma. The epithelial cells showed positive staining with pan-cytokeratin, BerEP4, p63, and keratin 5/6 and were focally positive for S-100, calponin, and actin, consistent with myoepithelial differentiation. An epithelial membrane antigen stain highlighted the scattered ductal structures. The high-grade spindle cell areas were negative for S-100, actin, desmin, calponin, p63, epithelial membrane antigen, and keratin 5/6.

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“…Although it should be noted that two patients with low-grade tumors developed metastasis, of which one patient succumbed to the disease. MECA have, besides the mammary gland, also been described in the nasopharynx [4,5], lung [6], larynx [7,8], the infratemporal fossa [9], orbit [10] and skin [11][12][13].…”

Section: Discussionmentioning

confidence: 99%

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

Petersson

Chao

2010

Head and Neck Pathol

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We present a 45 year old female patient with a nasal carcinoma showing high-grade/anaplastic histomorphological features and with a distinct myoepithelial immunohistochemical phenotype including positivity for smooth muscle actin, p63, S100 protein with no sustentacular pattern, calponin, cytokeratin 14, vimentin and cytokeratins (AE1-3 and CK5/6). A minority (\5%) of the cells showed focal and variable immunoreactivity for EMA with no cuticular/canalicular pattern. Bcl-2, CD99, CD117 and CD56 were variously positive, but chromogranin and synaptophysin were negative. Weak to moderate nuclear p53 immunoreactivity was seen in 50% of tumor cells. Mib-1/Ki-67 showed an average proliferation of 60-70%. Fluorescent in situ hybridization revealed no EWS-gene translocation. In situ hybridization for EBER was negative.

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A case of cutaneous myoepithelial carcinoma

Abstract: The final diagnosis was cutaneous myoepithelial carcinoma. At present, it seems to be difficult to predict the behavior of myoepithelioma of the skin and soft tissue, although atypia and high mitotic rate are reported to be associated with local recurrence and metastasis.

Cited by 36 publications

References 17 publications

Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors

Cutaneous syncytial myoepithelioma: A case report with emphasis on the differential diagnosis of problematic dermal tumors

Cutaneous Carcinosarcoma With Myoepithelial Differentiation: Immunohistochemical and Cytogenetic Analysis of a Case Presenting in an Unusual Location

Anaplastic Myoepithelial Carcinoma of the Sinonasal Tract: an Underrecognized Salivary-Type Tumor Among the Sinonasal Small Round Blue Cell Malignancies? Report of One Case and a Review of the Literature

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