A Case of Cutaneous Plasmacytosis

Ishii, Norihisa; Hayashi, Masayuki; Nakajima, Hiroshi; Nagai, Ryukichi

doi:10.1111/j.1346-8138.1984.tb01526.x

Cited by 15 publications

(7 citation statements)

References 12 publications

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“…polyclonal plasma cells, predominantly on the trunk [1][2][3]. This condition has been recognized principally in Asian patients, with a few cases in whites [4][5][6][7].…”

mentioning

confidence: 97%

High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis—is this a cutaneous manifestation of IgG4-related disease?

Miyagawa‐Hayashino¹,

Matsumura²,

Kawakami³

et al. 2009

Human Pathology

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Cutaneous plasmacytosis is a rare condition affecting middle-aged individuals, characterized by multiple red-brown papules and plaques over the trunk. It has been reported mainly in Japan. The condition is accompanied by polyclonal hypergammaglobulinemia and superficial lymphadenopathy. Lung or retroperitoneal involvement occurs rarely. In the present study, 3 consecutive cases of cutaneous plasmacytosis were observed histologically to have abundant infiltration of IgG4-bearing plasma cells. All 3 were associated with superficial lymphadenopathy, one with interstitial lung involvement showing ground-glass opacity on computed tomography and the others with bone marrow plasmacytosis, showing histologic evidence of more IgG4-positive plasma cells. All 3 had polyclonal hypergammaglobulinemia, one had high serum concentration of IgG4, and all had elevated serum IL-6. The ratios of IgG4+ to IgG+ plasma cells were assessed using skin biopsy specimens with pemphigus (n = 7), discoid lupus erythematosus (n = 5), and morphea (n = 2) (mean ratios, 19%, 0%, and 0%, respectively); we noted the proportion of IgG4-positive plasma cells in cutaneous plasmacytosis (mean, 48%). IgG4-related sclerosing disease is a newly recognized systemic disorder characterized by lymphoplasmacytic infiltration and fibrosis and by a high serum IgG4 level and increased IgG4-positive plasma cells in the tissues. Skin manifestations of this disorder have not been described. Although cutaneous plasmacytosis could be a chronic allergic hypersensitivity reaction, our findings raise the possibility of a relationship in pathogenesis between cutaneous plasmacytosis and IgG4-related sclerosing disease.

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“…polyclonal plasma cells, predominantly on the trunk [1][2][3]. This condition has been recognized principally in Asian patients, with a few cases in whites [4][5][6][7].…”

mentioning

confidence: 97%

High ratio of IgG4-positive plasma cell infiltration in cutaneous plasmacytosis—is this a cutaneous manifestation of IgG4-related disease?

Miyagawa‐Hayashino¹,

Matsumura²,

Kawakami³

et al. 2009

Human Pathology

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“…It consists of a triad of cutaneous lesions, superficial lymphadenopathy, and polyclonal hypergammaglobulinemia. [ 1 2 ] It was first reported in 1976, with the first case in English literature being reported by Watanabe et al ., in 1986. [ 3 ]…”

Section: Discussionmentioning

confidence: 99%

Primary cutaneous plasmacytosis: Masquerading as hidradenitis suppurativa

Goyal¹,

Varshney²,

Zawar³

et al. 2016

Indian J Dermatol

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Isolated cutaneous plasmacytosis (CP) is a rare entity with few cases reported in world literature. CP masquerading as hidradenitis suppurativa like presentation is a unique case with some features differentiating it clinically from it which were further confirmed by histopathology and immunostaining. Our case showed hyperplasia of mature plasma cells and polyclonal hypergammaglobulinemia, immunostaining for CD138 positivity and kappa: lambda ratio more than 3:1. Extensive clinical and laboratory investigations failed to reveal any underlying pathology, presence of any underlying disease accompanying the hypergammaglobulinemia and/or plasma cell proliferation.

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“…The clinical differential diagnosis of multiple brown pigmented papules and plaques includes lymphoma, leukemia, urticaria pigmentosa, and infections such as syphilis . The pigmented skin lesions of cutaneous plasmacytosis result from increased pigmentation of the basal layer.…”

Section: Discussionmentioning

confidence: 99%

“…Cutaneous plasmacytosis was first described by Yashiro et al . and further characterized by Kitamura et al ., Aso and Shimao, and Ishii et al . Kimura et al .…”

Section: Introductionmentioning

confidence: 95%