A case of death of patient with ovarian fibroma combined with Meigs Syndrome and literature review

Abstract

Ovarian fibroma is the most common benign pure stromal tumor. It has no specific clinical manifestation, most of which are pelvic or adnexal masses. 10-15% of cases with hydrothorax or ascites, after tumor resection, hydrothorax and ascites disappear, known as Meigs Syndrome. The elevated level of CA125 in a few patients was easily misdiagnosed as ovarian malignant tumor. A case of bilateral Ovarian fibroma associated with Meigs Syndrome is reported and the literature is reviewed in order to improve the understanding of the changes and avoid misdiagnosis.

Mucin-Producing Lobular Breast Carcinoma Metastasis to an Ovarian Fibroma: Histopathological and Immunohistochemical Analysis of a Rare Case and Literature Review

“…Additionally, while elevated levels of CA-125 are rare in fibromas, some studies suggest that mechanical stimulation of the peritoneum in the presence of ascites can result in elevated CA-125 levels, potentially leading to misdiagnosis of malignant ovarian tumors. Rare instances have been reported wherein fibromas spread and adhere to adjacent tissues, resulting in fatal outcomes [35]. Moreover, normal serum CA-125 levels are observed in up to 35% of cases of ovarian metastases from non-gynecological neoplasms [8].…”

“…Fibromas constitute common benign stromal ovarian sex-cord tumors, accounting for 1-4% of all ovarian neoplasms [34][35][36]. Ovarian fibromas typically present as unilateral, well-circumscribed solid masses.…”

Síndrome de pseudo-meigs secundario a leiomioma uterino. Reporte de un caso

“…El tratamiento de elección es quirúrgico mediante laparotomía exploradora, siendo útil el corte congelado en tumores ováricos para decidir el alcance de la intervención al confirmar la naturaleza benigna o maligna de la tumoración. En mujeres de edad reproductiva, la salpingooforectomía unilateral es el tratamiento de elección, mientras que, en mujeres posmenopáusicas, la histerectomía abdominal total con salpingooforectomía bilateral es preferida (4,13).…”

Síndrome de Meigs: Relato de Caso

“…É composto por fibroblastos fusiformes ou ovais semelhantes a células produtoras de colágeno. Entre os tumores estromais de cordão sexual, o fibroma ovariano é o tumor mais comum, representando 4% de todos os tumores ovarianos e ocorre mais comumente em mulheres na quarta década de vida 8 . Geralmente, apresentam-se como massas pélvicas ou anexiais palpáveis com tamanho médio de 8 cm, entretanto, podem ser assintomáticos, pois cerca de um terço dos tumores pode ter menos de 3 cm 8,9 .…”