A Case of Doxycyclin-induced Photo-onycholysis with Dermoscopic Features

Elmas, Ömer Faruk; Akdeniz, Necmettın

doi:10.4274/balkanmedj.galenos.2019.11.22

Cited by 1 publication

(2 citation statements)

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“…It can involve both hand and feet, sparing or not some fingers. Usually, it involves some fingers of the hands, in fact the sparing of the photo‐protected toenails strongly supported the diagnosis of photo‐induced onycolysis 45 …”

Section: Discussionmentioning

confidence: 83%

“…Usually, it involves some fingers of the hands, in fact the sparing of the photoprotected toenails strongly supported the diagnosis of photo-induced onycolysis. 45 Lymecycline is not available in North America (but widely used in Europe) and, excluding the drugs currently not anymore available (DMC, oxytetracycline), the number of TCs related phototoxic reactions, considering the wide use if these drugs, is relatively low. It can be the consequence either of actual low incidence or misdiagnosis or scarce tendency to report adverse events usually mild in severity.…”

Section: Discussionmentioning

confidence: 99%

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Tetracyclines and photosensitive skin reactions: A narrative review

Odorici

Monfrecola

Bettoli

2021

Dermatologic Therapy

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Tetracyclines are a group of broad-spectrum antibiotics largely employed in infectious, dermatological and surgical fields. Some adverse events may occur during treatment, including photosensitivity reactions, which are divided in phototoxic or photoallergic.We performed a systematic search on Pubmed, Cochrane and Embase from database inception to August 9, 2020 aim to summarize all available papers on photosensitive reactions related to tetracyclines in all clinical settings where they are used on human being. On the basis of our inclusion criteria, we selected only randomized controlled trials, open comparative trials and prospective cohort studies performed on both volunteers and patients, moreover we included a pharmacovigilance register. Thirty-eight articles met inclusion criteria, describing photo-sensitive effects due to doxycycline, minocycline, tetracycline, lymecycline, sarecycline, demethylchlortetracycline, chlortetracycline and metacycline, across six diagnoses (acne, Lyme disease, Gulf Veteran Illness, adbominal aortic aneurysms, traveler's diarrhea and pterygium) and several volunteers who were deliberately exposed to natural or artificial light sources. Not all drugs belonging to tetracyclines class are available to date, moreover the studies included lacked a homogeneous design and most of them involved a scarce number of patients, including reactions induced in volunteers during photo-testing. Available data on incidence, severity and clinical relevance of tetracyclines-related photo-sensitive reactions are scarce, heterogeneous and weak. What we can extrapolate is that some tetracyclines are more often related to phototoxic skin reactions than others and some of those seem to have a very low risk of phototoxicity.

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%