A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab

Kikuchi, Saori; Yoshida, Saeko; Sugiyama, Tomonori; Iino, Yukiko

doi:10.1016/j.xocr.2021.100381

Cited by 4 publications

(1 citation statement)

References 12 publications

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“…Thus, surgical intervention for EOM has long been considered contraindicated. We previously reviewed 24 patients who underwent tympanoplasty/mastoidectomy beginning in 2006 (18). All 24 patients developed relapse soon after the surgical procedure.…”

Section: Discussionmentioning

confidence: 99%

Myringoplasty for Eosinophilic Otitis Media

et al. 2023

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ObjectiveSurgical intervention of eosinophilic otitis media (EOM) has been considered contraindicated because middle ear surgery is associated with a risk of deafness. Myringoplasty is believed to be less invasive. Therefore, we analyzed the surgical results of myringoplasty for perforated eardrums in patients with EOM treated by biological drugs (biologics).Study DesignRetrospective chart review.SettingTertiary referral center.PatientsNine ears of seven patients with EOM with eardrum perforation associated with bronchial asthma were treated with add-on biologics; myringoplasty was then performed. The controls comprised 17 ears of 11 patients with EOM treated by myringoplasty without biologics.InterventionsThe EOM status of each patient of both groups was assessed using severity scores, hearing acuity, and temporal bone computed tomography scores.Main Outcome MeasuresPreoperative and postoperative changes in severity scores and hearing acuity, postoperative closure of the perforation, and relapse of EOM.ResultsSeverity scores significantly decreased after the use of biologics but did not change after myringoplasty. One patient developed postoperative relapse of middle ear effusion (MEE); in the control group, however, 10 ears developed recurrence of MEE. Significant improvement of the air conduction hearing level was obtained in the biologics group. No patients showed deterioration of the bone conduction hearing level.ConclusionsThis is the first report to describe successful surgical interventions with add-on biologics for patients with EOM. In the era of biologics, surgical interventions such as myringoplasty will be indicated to improve hearing and to avoid recurrence of MEE in patients with EOM with perforated eardrums, with the use of biologics.

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Section: Discussionmentioning

confidence: 99%

Myringoplasty for Eosinophilic Otitis Media

et al. 2023

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Eosinophilic otitis media; state-of-the-art diagnosis and treatment

Iino

2023

Auris Nasus Larynx

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Dupilumab in the Treatment of Eosinophilic Otitis Media: A Case Report

Kim,

Jin,

Kim

et al. 2024

Korean J Otorhinolaryngol-Head Neck Surg

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Eosinophilic otitis media (EOM) differs from classic chronic otitis media as it is a refractory disease with the accumulation of eosinophils in thick mucinous middle ear effusion and mucosa. A 66-year-old male with a history of asthma, chronic sinusitis with polyposis, nasal polyposis, and multiple sets of ventilation tubes was presented to our center for the management of hearing loss and otorrhea. He had a history of consistent otorrhea and hearing loss even with the ventilation tube insertions and medical treatment. Both systemic and intratympanic steroid was administered, but the effect was insignificant and other systemic adverse effects occurred. Finally, the otologic symptoms including hearing loss and otorrhea improved after being given a Dupilumab injection. This case report discusses Dupilumab treatment resulting in remission in a patient suffering from refractory EOM.

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A case of eosinophilic otitis media successfully treated by tympanoplasty with use of dupilumab

Cited by 4 publications

References 12 publications

Myringoplasty for Eosinophilic Otitis Media

Myringoplasty for Eosinophilic Otitis Media

Eosinophilic otitis media; state-of-the-art diagnosis and treatment

Dupilumab in the Treatment of Eosinophilic Otitis Media: A Case Report

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