Osteosarcoma is the most common primary bone tumor arising from mesenchymal bone forming cells. The most frequent sites of metastasis are lungs, bones and kidneys. Osteosarcomas rarely metastasize to scalp and pleura. Here, we report a case of a 65-year-old male patient with complaints of shortness of breath and painful swelling in right knee joint and also a small nodule on scalp. Contrast enhanced computed tomography (CECT) of thorax revealed irregular pleural lesions causing indentation over underlying lung parenchyma on both side while CT abdomen revealed metastatic lesion in liver. Patient came to our department for FNAC from swelling right knee and scalp nodule. Later pleural biopsy was also received of the same patient. A final diagnosis of osteosarcoma of the right knee joint was made with scalp, and pleural metastasis. This case underlines the importance of warranting further investigations for search of unusual sites of metastasis from osteosarcoma.