Extraskeletal Osteosarcoma of Subcutaneous Soft Tissue with Lymph Node and Skin Metastasis: A Case Report with Fluorescence in Situ Hybridization Analysis

Papachristou, Dionysios J.; Goodman, Mark A.; Cieply, Kathleen; Rao, Uma

doi:10.1007/s12253-010-9349-4

Cited by 6 publications

(15 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several of these tumors were noted to arise in locations of prior trauma (eg, prior burn, radiation, electrodesiccation, etc) . In contrast to primary cutaneous ESOS, metastatic cutaneous ESOS has also been reported, either from classic osteosarcoma or ESOS, but is exceedingly rare, with only 22 cases in the literature …”

Section: Discussionmentioning

confidence: 99%

A rare variant of extraskeletal osteosarcoma presenting as a clinically benign subcutaneous neoplasm

Ryan

Woolridge

Sedrak³

et al. 2019

J Cutan Pathol

View full text Add to dashboard Cite

Extraskeletal osteosarcoma (ESOS) is a rare variant of osteosarcoma that arises without attachment to the underlying skeleton. These cancers are typically found embedded in deeper tissues, most commonly the muscle or fascia, and are rarely found within the skin or subcutis. Most tumors are large in size upon initial presentation, and carry a poor prognosis. We discuss the case of a 48-year-old Caucasian woman who presented to a dermatology clinic with an asymptomatic, small, mobile, subcutaneous mass that appeared clinically benign. After elective removal and histopathologic examination, the patient was diagnosed with ESOS. ESOS presenting in this manner is exceedingly rare, and this case highlights the importance of sending all excised specimens, even those with a benign presentation, for pathologic examination. K E Y W O R D Sdermatology, extraskeletal osteosarcoma, neoplasm, pathology, skin

show abstract

Section: Discussionmentioning

confidence: 99%

A rare variant of extraskeletal osteosarcoma presenting as a clinically benign subcutaneous neoplasm

Ryan

Woolridge

Sedrak³

et al. 2019

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…[3,8,20,21]. Чаще опухоль возникает de novo (≥90%) [10,22]. Вторичное развитие заболевания наблюдается в 5-10% случаев [3,10,22].…”

unclassified

“…Чаще опухоль возникает de novo (≥90%) [10,22]. Вторичное развитие заболевания наблюдается в 5-10% случаев [3,10,22]. В патогенезе вторичной ЭСО фигурируют факторы, индуцирующие развитие опухолевого процесса, в первую очередь травма и ионизирующее излучение (общее и локальное), а также злокачественная трансформация [9][10][11]23].…”

unclassified

“…Вторичное развитие заболевания наблюдается в 5-10% случаев [3,10,22]. В патогенезе вторичной ЭСО фигурируют факторы, индуцирующие развитие опухолевого процесса, в первую очередь травма и ионизирующее излучение (общее и локальное), а также злокачественная трансформация [9][10][11]23]. Среди травматических поражений, обусловливающих развитие ЭСО, отмечаются хроническое раздражение кожи, внутримышечная инъекция, перелом кости [8,11].…”

unclassified

“…Отмечено злокачественное перерождение предсуществующих доброкачественных опухолей -оссифицирующей липомы, оссифицирующей фибромиксоидной опухоли, фиброаденомы молочной железы, филлоидной опухоли молочной железы [27][28][29]. Возрастное распределение ЭСО охватывает пятое-седьмое десятилетие, пик заболеваемости приходится на шестую декаду жизни, и лишь в 12% наблюдений возраст больных составляет менее 30 лет [1,3,10]. Наиболее типично развитие опухоли в мягких тканях проксимальных отделов нижних конечностей, преимущественно в бедре (2,3-52%), в верхних конечностях -в плече (8-23 %) [1, 2, 6, 9-11, 24, 30].…”

unclassified

See 2 more Smart Citations

Extraskeletal osteosarcoma: nosologocal diversity, morphology, differential diagnosis, and features of metastasis

et al. 2018

View full text Add to dashboard Cite

Extraskeletal osteosarcoma is a rare malignant tumor with histologic similarities to primary bone osteosarcoma. However, there are distinct differences in epidemiology, imaging features, biological characteristics, prognosis, and management compared with osteogenic osteosarcoma. Extraskeletal osteosarcoma is usually characterized as high-grade neoplasm with clinically aggressive behavior, poor prognosis, frequent recurrence/lymphogenic metastatsis, and resistence to chemotherapy. A noteworthy feature of extraskeletal osteosarcoma is the fact that almost all existing biological phenomena described in mesenchymal oncopathology (except primary-multiple lesions) are present in this tumor, namely: secondary malignancy, association with syndromes, partial spontaneous regression of the tumor, dedifferentiation, bone invasion, biphasic pathology. In this paper, we have discussed in detail the tumor morphology, histological subtypes, prognostic factors and differential diagnosis.

show abstract

Primary cutaneous extraskeletal osteosarcoma: a series of 16 cases

et al. 2023

View full text Add to dashboard Cite

Extraskeletal Osteosarcoma of Subcutaneous Soft Tissue with Lymph Node and Skin Metastasis: A Case Report with Fluorescence in Situ Hybridization Analysis

Cited by 6 publications

References 19 publications

A rare variant of extraskeletal osteosarcoma presenting as a clinically benign subcutaneous neoplasm

A rare variant of extraskeletal osteosarcoma presenting as a clinically benign subcutaneous neoplasm

Extraskeletal osteosarcoma: nosologocal diversity, morphology, differential diagnosis, and features of metastasis

Primary cutaneous extraskeletal osteosarcoma: a series of 16 cases

Contact Info

Product

Resources

About